A5046059508- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Non-Invasive Vital Sign Monitoring
- Advanced Radiotherapy Techniques
- MRI in cancer diagnosis
- Neuroendocrine Tumor Research Advances
- Mathematical Biology Tumor Growth
- Retinal Imaging and Analysis
- Heart Rate Variability and Autonomic Control
- Renal cell carcinoma treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal and related cancers
- Cardiovascular Health and Disease Prevention
- Pancreatitis Pathology and Treatment
- Cancer Immunotherapy and Biomarkers
- Phagocytosis and Immune Regulation
- Imbalanced Data Classification Techniques
- Medical Imaging Techniques and Applications
- Retinal and Optic Conditions
- Hemodynamic Monitoring and Therapy
- Radiation Therapy and Dosimetry
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Cells and Metastasis
University of Maine
2023-2024
Ain Shams University
2010-2024
University of Missouri
2021-2023
Vellore Institute of Technology University
2023
The University of Texas MD Anderson Cancer Center
2017-2022
Saveetha University
2022
AbbVie (United States)
2019
Novartis (Switzerland)
2019
Merck Serono (Switzerland)
2019
Q Therapeutics (United States)
2019
Abstract Purpose: Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous disease with variable presentations and natural histories of disease. We hypothesized that different morphologic characteristics PDAC tumors on diagnostic computed tomography (CT) scans would reflect their underlying biology. Experimental Design: developed quantitative method to categorize the morphology pretherapy CT from multiple datasets patients resectable metastatic correlated these patterns clinical/pathologic...
BACKGROUND The assessment of pancreatic ductal adenocarcinoma (PDAC) response to therapy remains challenging. objective this study was investigate whether changes in the tumor/parenchyma interface are associated with response. METHODS Computed tomography (CT) scans before and after were reviewed 4 cohorts: cohort 1 (99 patients stage I/II PDAC who received neoadjuvant chemoradiation surgery); 2 (86 IV chemotherapy), 3 (94 protocol‐based gemcitabine chemoradiation), (47 prospectively followed...
Alterations in microvasculature represent some of the earliest pathological processes across a wide variety human diseases. In many organs, however, inaccessibility and difficulty directly imaging tissues prevent assessment microvascular changes, thereby significantly limiting their translation into improved patient care. The eye provides unique solution by allowing for non-invasive direct visualization quantification aspects microvasculature, including biomarkers structure, function,...
Effective preoperative regimens and biomarkers for pancreatic ductal adenocarcinoma (PDAC) are lacking. We prospectively evaluated fluorouracil, leucovorin, irinotecan, oxaliplatin (FOLFIRINOX)-based treatment imaging-based borderline resectable PDAC.Eligible patients had treatment-naïve, histology-confirmed PDAC one or more high-risk features: mesenteric vessel involvement, CA 19-9 level of 500 mg/dL greater, indeterminate metastatic lesions. Patients received modified FOLFIRINOX...
Purpose Response assessment of radiotherapy for the treatment intrahepatic cholangiocarcinoma (IHCC) across longitudinal images is challenging due to anatomical changes. Advanced deformable image registration (DIR) techniques are required correlate corresponding tissues time. In this study, accuracy five commercially available DIR algorithms in four planning systems (TPS) was investigated with posttreatment follow‐up response or re‐treatment purposes. Methods Twenty‐nine IHCC patients...
Previously, we characterized qualitative imaging-based subtypes of pancreatic ductal adenocarcinoma (PDAC) on computed tomography (CT) scans. Conspicuous (high delta) PDAC tumors are more likely to have aggressive biology and poorer clinical outcomes compared inconspicuous (low tumors. Here, developed a quantitative classification this subtype (quantitative delta; q-delta). Retrospectively, baseline protocol CT scans three cohorts (cohort#1 = 101, cohort#2 90 cohort#3 16 [external...
Purpose: This study proposes a novel approach to obtain personalized estimates of cardiovascular parameters by combining (i) electrocardiography and ballistocardiography for noninvasive monitoring, (ii) physiology-based mathematical model predicting variables, (iii) an evolutionary algorithm (EA) searching optimal parameters. Methods: Electrocardiogram (ECG), ballistocardiogram (BCG), total six blood pressure measurements are recorded on three healthy subjects. The R peaks in the ECG used...
Left ventricular (LV) catheterization provides LV pressure-volume (P-V) loops and it represents the gold standard for cardiac function monitoring. This technique, however, is invasive this limits its applicability in clinical in-home settings. Ballistocardiography (BCG) a good candidate non-invasive monitoring, as based on capturing non-invasively body motion that results from blood flowing through cardiovascular system. work aims at building mechanistic connection between changes BCG...
Deformable image registration (DIR) of longitudinal liver cancer computed tomographic (CT) images can be challenging owing to anatomic changes caused by radiation therapy (RT) or disease progression. We propose a workflow for the DIR contrast-enhanced CT scans based on biomechanical model driven boundary conditions surface and centerline an autosegmentation vasculature.
Previously, we characterized subtypes of pancreatic ductal adenocarcinoma (PDAC) on computed-tomography (CT) scans, whereby conspicuous (high delta) PDAC tumors are more likely to have aggressive biology and poorer clinical outcomes compared inconspicuous (low tumors. Here, hypothesized that these imaging-based would exhibit different growth-rates distinctive metabolic effects in the period prior diagnosis.Retrospectively, evaluated 55 patients who developed as a second primary cancer...
Purpose Currently, radiologists use tumor‐to‐normal tissue contrast across multiphase computed tomography (MPCT) for lesion detection. Here, we developed a novel voxel‐based enhancement pattern mapping (EPM) technique and investigated its ability to improve contrast‐to‐noise ratios (CNRs) in phantom study patients with hepatobiliary cancers. Methods The EPM algorithm is based on the root mean square deviation between each voxel normal liver model using patient‐specific (EPM‐PA) or population...
Although escalated doses of radiation therapy (RT) for intrahepatic cholangiocarcinoma (iCCA) are associated with durable local control (LC) and prolonged survival, uncertainties persist regarding personalized RT based on biological factors. Compounding this knowledge gap, the assessment response using traditional size-based criteria via computed tomography (CT) imaging correlates poorly outcomes. We hypothesized that quantitative measures enhancement would more accurately predict clinical...
Effective consolidative chemoradiation (CRT) regimens are lacking. In this phase 1 trial, we evaluated the safety and efficacy of nab-paclitaxel, capecitabine, radiation therapy after induction chemotherapy in patients with locally advanced borderline-resectable pancreatic cancer (LAPC BRPC). Also, a computed tomography (CT)-based biomarker response.Eligible had pathologically confirmed ductal adenocarcinoma, underwent tomography-imaging, received diagnosis LAPC or BRPC, chemotherapy....
Computational Fluid Dynamics (CFD) has been used to assess HVAC system performance in plant and animal control facilities the past few years. Indoor farming is a fully enclosed environment agriculture structure developed create an optimum growing for lettuce. Airflow uniformity temperature distribution were important indoor factories as it accountable creating ideal uniform conditions This study was conducted understand analyze airflow characteristics changes shipping container factory with...
Discrepancies between planned and delivered dose to GI structures during radiation therapy (RT) of liver cancer may hamper the prediction treatment outcomes. The purpose this study is develop a streamlined workflow for accumulation in planning system (TPS) image-guided RT assess its accuracy when using different deformable image registration (DIR) algorithms.Fifty-six patients with primary metastatic treated external beam radiotherapy guided by daily CT-on-rails (CTOR) were retrospectively...
We have previously shown that ablative radiotherapy (A-RT) with a biologically effective dose (BED10) ≥ 80.5 Gy for patients unresectable intrahepatic cholangiocarcinoma (ICC) is associated longer survival. Despite recent large-scale sequencing efforts in ICC, outcomes following RT based on genetic alterations not been described. reviewed records of 156 consecutive treated A-RT ICC from 2008 to 2020. For 114 (73%), next-generation provided molecular profiles. The overall survival (OS), local...
In this study, anatomical and functional differences between men women in their cardiovascular systems how these manifest blood circulation are theoretically experimentally investigated. A validated mathematical model of the system is used as a virtual laboratory to simulate compare multiple scenarios where parameters associated with sex varied. Cardiovascular related women’s faster heart rate, stronger ventricular contractility, smaller vessels inputs quantify impact (i) on distribution...
The time interval between the peaks in electroccardiogram (ECG) and ballistocardiogram (BCG) waveforms, TEB, has been associated with pre-ejection period (PEP), which is an important marker of ventricular contractility. However, applicability BCG-related markers clinical practice limited by difficulty to obtain a replicable consistent signal on patients. In this study, we test feasibility BCG measurements within complex setting, means accelerometer under head pillow patients admitted...
PurposeThe benefit of radiation therapy for pancreatic ductal adenocarcinoma (PDAC) remains unclear. We hypothesized that a new mechanistic mathematical model chemotherapy and response could predict clinical outcomes priori, using previously described baseline measurement perfusion from computed tomography scans, normalized area under the enhancement curve (nAUC).Methods MaterialsWe simplified an existing mass transport predicted cancer cell death by replacing unknown variables with averaged...
Introduction: Superior mesenteric artery syndrome (SMAS) is a rare entity that cause duodenal obstruction.This study analyzes twelve patients underwent laparoscopic Duodenojejunostomy as management of SMAS. Patients and methods:We are analyzing data (3 males 9 females) duodenojejunostomy for SMAS, one them antrectomy with Roux-en-Y gastrojejunostomy from NOV 2020 to FEB 2023, mean age 23.3 years.Results: Twelve were included years.The most common was idiopathic in 58.3%.Abdominal pain...