A5009301625- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Head and Neck Cancer Studies
- Medical Imaging and Analysis
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiation Dose and Imaging
- Radiation Therapy and Dosimetry
- Advances in Oncology and Radiotherapy
- Lung Cancer Diagnosis and Treatment
- Anatomy and Medical Technology
- Chemical Safety and Risk Management
- Optical Imaging and Spectroscopy Techniques
- AI in cancer detection
- Cholangiocarcinoma and Gallbladder Cancer Studies
The University of Texas MD Anderson Cancer Center
2018-2024
University of Michigan–Ann Arbor
2015-2019
Current standard radiotherapy for oropharynx cancer (OPC) is associated with high rates of severe toxicities, shown to adversely impact patients' quality life. Given excellent outcomes human papilloma virus (HPV)-associated OPC and long-term survival these typically young patients, treatment de-intensification aimed at improving survivorship while maintaining disease control now a central concern. The recent implementation magnetic resonance image - guided (MRgRT) systems allows individual...
Abstract Manual delineation of liver segments on computed tomography (CT) images for primary/secondary cancer (LC) patients is time-intensive and prone to inter/intra-observer variability. Therefore, we developed a deep-learning-based model auto-contour spleen contrast-enhanced CT (CECT) images. We trained two models using 3d patch-based attention U-Net ( $${{\text{M}}}_{{\text{paU}}-{\text{Net}}})$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msub>...
Purpose Response assessment of radiotherapy for the treatment intrahepatic cholangiocarcinoma (IHCC) across longitudinal images is challenging due to anatomical changes. Advanced deformable image registration (DIR) techniques are required correlate corresponding tissues time. In this study, accuracy five commercially available DIR algorithms in four planning systems (TPS) was investigated with posttreatment follow‐up response or re‐treatment purposes. Methods Twenty‐nine IHCC patients...
Objective assessment of deformable image registration (DIR) accuracy often relies on the identification anatomical landmarks in pairs, a manual process known to be extremely time-expensive. The goal this study is propose method automatically detect vessel bifurcations images and assess their use for computation target errors (TREs).
This study aimed to analyze the potential clinical impact of differences between planned and accumulated doses on development use normal tissue complication probability (NTCP) models.
The purpose of this study was to assess the attitudes occupationally exposed employees at a large teaching hospital about wearing their assigned personal radiation dosimeters. A 16-question multiple-answer survey used report reasons why medical professionals may not wear dosimetry during procedures involving ionizing radiation. In all, 302 responded survey. majority respondents who reported always or almost dosimeters do so because they consider themselves well informed concerning importance...
Re-planning for four-dimensional computed tomography (4DCT)-based lung adaptive radiotherapy commonly requires deformable dose mapping between the planning average-intensity image (AVG) and newly acquired AVG. However, such AVG-AVG registration (DIR) lacks accuracy assessment. The current work quantified compared geometric accuracies of DIR corresponding phase-phase DIRs, subsequently investigated clinical impact on mapping.Hybrid intensity-based DIRs were performed mid-treatment 4DCTs 28...
Discrepancies between planned and delivered dose to GI structures during radiation therapy (RT) of liver cancer may hamper the prediction treatment outcomes. The purpose this study is develop a streamlined workflow for accumulation in planning system (TPS) image-guided RT assess its accuracy when using different deformable image registration (DIR) algorithms.Fifty-six patients with primary metastatic treated external beam radiotherapy guided by daily CT-on-rails (CTOR) were retrospectively...
Early animal studies suggest that parotid gland (PG) toxicity prediction could be improved by an accurate estimation of the radiation dose to sub-regions PG. Translation clinical investigation requires voxel-level accumulation in this organ responds volumetrically throughout treatment. To date, deformable image registration (DIR) has been evaluated for PG using only surface alignment. We sought develop and evaluate advanced DIR technique capable modeling these complex volume changes over...
During head and neck (HN) cancer radiation therapy, analysis of the dose-response relationship for parotid glands (PG) relies on ability to accurately align soft tissue organs between longitudinal images.In order isolate response salivary delivered dose, from deformation due patient position, it is important resolve postural changes, mainly flexion.In this study we evaluate use a biomechanical model-based deformable image registration (DIR) algorithm estimate displacements deformations...
Purpose: Previous studies have shown that radiotherapy treatment for liver metastases causes marked hypertrophy in areas receiving low dose and atrophy/fibrosis high dose. The purpose of this work is to develop evaluate a biomechanical model-based dose-response model describe these responses SBRT. Methods: In retrospective study, deformable registration algorithm, Morfeus, was expanded include dose-based boundary conditions. Liver tumor volumes were contoured on the planning images CT/MR...
Purpose: It is well documented that the delivered dose to patients undergoing radiotherapy (RT) often different from planned due geometric variability and uncertainties in patient positioning. Recent work suggests accumulated GTV a better predictor of progression compared minimum PTV. The purpose this study evaluate if deviations can contributed tumor progression. Methods: From 2010 2014 an in‐house Phase II clinical trial adaptive stereotactic body RT was completed. Of 90 enrolled, 7 had...
Widespread clinical use of dose accumulation and adaptive radiotherapy has been hampered by limited tools to efficiently aggregate evaluate data. The purpose this work is assess the feasibility daily advanced analytical support head neck cancers in practice. Dose (Dacc) accuracy impact was evaluated on more than 350 CBCT CT images HN cancer patients enrolled a prospective registry cohort evaluating sub-weekly target volume/OAR radiation therapy using previously validated DIR algorithm....
Abstract Purpose Precise correlation between three‐dimensional (3D) imaging and histology can aid biomechanical modeling of the breast. We develop a framework to register ex vivo images using novel cryo‐fluorescence tomography (CFT) device. Methods A formalin‐fixed cadaveric breast specimen, including chest wall, was subjected high‐resolution magnetic resonance (MR) imaging. The specimen then frozen embedded in an optimal cutting temperature (OCT) compound. OCT block placed CFT device with...