A5046803677- Protein Degradation and Inhibitors
- Multiple Myeloma Research and Treatments
- Melanoma and MAPK Pathways
- Peptidase Inhibition and Analysis
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- CAR-T cell therapy research
- Extracellular vesicles in disease
- Astronomical Observations and Instrumentation
- Astro and Planetary Science
- Lung Cancer Treatments and Mutations
- Chemokine receptors and signaling
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Stellar, planetary, and galactic studies
- Satellite Image Processing and Photogrammetry
- Cancer Mechanisms and Therapy
- Radiation Therapy and Dosimetry
- Historical Geography and Cartography
- Medical Imaging Techniques and Applications
- Astrophysics and Star Formation Studies
- Lung Cancer Diagnosis and Treatment
- Effects of Radiation Exposure
- Isotope Analysis in Ecology
- Photocathodes and Microchannel Plates
The University of Texas MD Anderson Cancer Center
2021-2024
Massachusetts General Hospital
2019-2023
Harvard University
2020-2023
Brigham and Women's Hospital
2017-2020
Dana-Farber Cancer Institute
2017-2020
Dana-Farber Brigham Cancer Center
2017-2020
University of Wisconsin–Madison
2011-2013
To investigate the usefulness and effectiveness of a dual beam-current transformer (BCTs) design to monitor record beam dosimetry output energy pulsed electron FLASH (eFLASH) beams in real-time, inform on this for future eFLASH control.Two BCTs are integrated into head Mobetron system, one located after primary scattering foil other downstream secondary foil. The response was evaluated individually as function dose, conditions, ability capture physical parameters such pulse width (PW),...
Abstract Purpose: Although remarkably effective in some patients, precision medicine typically induces only transient responses despite initial absence of resistance-conferring mutations. Using BRAF-mutated myeloma as a model for resistance to we investigated if cancer cells have the ability ensure their survival by rapidly adapting BRAF inhibitor treatment. Experimental Design: Full-length single-cell RNA (scRNA) sequencing (scRNA-seq) was conducted on 3 patients with and 1 healthy donor....
PurposeMR-guided radiotherapy (MRgRT) has the advantage of utilizing high soft tissue contrast imaging to track daily changes in target and critical organs throughout entire radiation treatment course. Head neck (HN) stereotactic body therapy (SBRT) been increasingly used treat localized lesions within a shorter timeframe. The purpose this study is examine dosimetric difference between step-and-shot intensity modulated (IMRT) plans on Elekta Unity our clinical volumetric arc (VMAT) Varian...
Abstract Introduction Limited stage small cell lung cancer (LS-SCLC) has a poor prognosis. Additional prognostic markers are needed for risk-stratification and treatment intensification. This study compares quantitative CT-based volumetric tumor measurements versus International Association the Study of Lung Cancer (IASLC) TNM staging to predict outcomes. Materials & methods A cohort 105 patients diagnosed with LS-SCLC treated chemoradiation (CRT) from 2000 2013 were analyzed...
After a successful eleven-year campaign at Kitt Peak, we moved the Wisconsin H-Alpha Mapper (WHAM) to Cerro Tololo in early 2009. Here present some of data after few months under southern skies. These maps begin complete first all-sky, kinematic survey diffuse H-alpha emission from Milky Way. Much this arises Warm Ionized Medium (WIM), significant component ISM that extends kiloparsecs above Galactic disk. While look focuses on survey, WHAM is also capable observing many other optical lines,...
<p>BCL2L11 expression in primary MM cells</p>
<p>Serial target evaluation in U266 single cell clones undergoing dabrafenib treatment</p>
<p>Transcriptional adaptation in DP6 persistent cells</p>
<p>Dabrafenib sensitivity in DP6 single clones</p>
<p>IACS-010759 sensitivity in dabrafenib-persistent vs. naïve single-cell clones</p>
<p>Antibodies used for Western Blot experiments</p>
<p>Copy number variations in dabrafenib-persistent U266 single-cell clones as compared to baseline</p>
<p>Transcriptional activation of oxidative phosphorylation pathway genes in U266 dabrafenib-persistent cells</p>
<p>Antibodies used for phenotyping and sorting of myeloma cells</p>
<p>Rotenone sensitivity in dabrafenib-persistent vs. naïve single-cell clones</p>
<p>Annotation of single cells based on origin</p>
<p>Dabrafenib sensitivity in dabrafenib-resistant U266 single-cell clones as compared to baseline</p>