A5005579728- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Corneal surgery and disorders
- Retinal Development and Disorders
- Neurological Disorders and Treatments
- Ophthalmology and Visual Impairment Studies
- Retinal and Optic Conditions
- Ocular Surface and Contact Lens
- Intraocular Surgery and Lenses
- Retinal and Macular Surgery
- Corneal Surgery and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Ocular and Laser Science Research
- Neurological Disease Mechanisms and Treatments
- Advanced Optical Imaging Technologies
- Natural Antidiabetic Agents Studies
- Retinopathy of Prematurity Studies
- Ophthalmology and Eye Disorders
- Photonic and Optical Devices
- Cholinesterase and Neurodegenerative Diseases
- Antimicrobial Resistance in Staphylococcus
- Advanced Glycation End Products research
- Drug-Induced Ocular Toxicity
- Biochemical and Structural Characterization
Fondazione G.B. Bietti
2019-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2024
Sapienza University of Rome
2012-2019
Institute of Genetic and Biomedical Research
2019
Policlinico Umberto I
2013-2016
Ospedale Santa Maria Goretti
2015
Précis: The relationship between structural and hemodynamic parameters in patients with primary open angle glaucoma is strongest the temporal region of optic nerve. Purpose: To investigate radial peripapillary capillary (RPC) vessel density (VD) retinal nerve fiber layer (RNFL) thickness quadrants sectors head (ONH) without (POAG). Methods: In a cross-sectional prospective analysis, 191 subjects (80 early-stage POAG; 111 non-glaucomatous controls) were assessed for RNFL RPC VD each quadrant...
Aims: The aim was to evaluate circulating levels of reactive oxygen species (ROS) and changes in central macular thickness (CMT) patients with nonproliferative diabetic retinopathy (NPDR) after antioxidant supplementation. Materials Methods: A total 68 (68 eyes) NPDR were enrolled. Patients randomly divided into two groups: Treated supplement (Group A) untreated control group B). Each tablet, for oral administration, containing pycnogenol 50 mg, Vitamin E 30 mg coenzyme Q10 20 mg. CMT free...
Abstract Objectives To evaluate the 1-year effectiveness and safety of XEN45, either alone or in combination with phacoemulsification, glaucoma patients. Methods This multicentre, prospective, observational study included consecutive eyes patients from Italian XEN-Glaucoma Treatment Registry (XEN-GTR) who underwent XEN45 at least 1 year follow-up. Surgical success was defined as intraocular pressure (IOP) < 18 mmHg ≥20% reduction preoperative IOP, over Results Two hundred thirty-nine (239...
Alterations in microvasculature represent some of the earliest pathological processes across a wide variety human diseases. In many organs, however, inaccessibility and difficulty directly imaging tissues prevent assessment microvascular changes, thereby significantly limiting their translation into improved patient care. The eye provides unique solution by allowing for non-invasive direct visualization quantification aspects microvasculature, including biomarkers structure, function,...
Précis: Capillary and neuronal tissue loss occur both globally with regional specificity in pre-perimetric glaucoma patients at the level of optic nerve macula, perifovea regions affected earlier than parafovea areas. Purpose: To investigate head (ONH) macular vessel densities (VD) structural parameters assessed by optical coherence tomography angiography open angle (ppOAG) healthy controls. Materials Methods: In all, 113 79 ppOAG underwent global (hemispheric/quadrants) assessments retinal,...
Purpose To evaluate the presence and concentration of citicoline its metabolites (choline, cytidine uridine) in vitreous body human eyes after topical application an ophthalmic solution 2%, vivo. Methods Twenty-one subjects affected by epiretinal membrane with surgical indication for pars-plana vitrectomy underwent treatment 1 drop 3 times/day a 0.2% high molecular weight hyaluronic acid 0.01% benzalkonium chloride (OMK1, Omikron Italia s.r.l., Rome, Italy) 14 days before surgery 2 hours...
Precis: XEN implant was associated with low endothelial cell density (ECD) reduction. In fact, when combined phacoemulsification, the reduction in ECD similar to that expected after phacoemulsification alone. Purpose: The purpose of this study assess impact implant, either alone or combination on ECD. Methods: Multicenter, prospective, observational conducted consecutive open-angle glaucoma patients, who were enrolled Italian Glaucoma Treatment Registry and have complete count data at...
Cystoid macular edema (CME) is a condition that involves the macula, causing painless vision loss. In this paper, we report case of niacin-induced bilateral cystoid in middle-age woman taking low dose niacin (18 mg nicotinic acid). Optical coherence tomography (OCT) showed retinal thickening and spaces both eyes, whereas fluorescein angiography (FA; HRA 2, Heidelberg Engineering) revealed absence leakage also later phases. Four weeks after discontinuation therapy there were complete...
SIGNIFICANCE The authors analyze factors influencing bivariate contour ellipse area (BCEA) in healthy and pathologic eyes how such may affect isolated (static BCEA) or microperimetric fixation (dynamic BCEA). They conclude that aging increases both dynamic BCEA examination time, whereas static offers less variance the maximum distinction with eyes. PURPOSE aim of this study was to assess recording method offer variability thus between METHODS A total 136 were retrospectively reviewed, 85...
To assess foveal microstructural changes influencing retinal sensitivity (RS) and fixation stability using microperimeter MP-1 in intermediate age-related macular degeneration (AMD). In this cross-sectional study, 22 eyes of patients (mean age: 75 ± 9.02 years) with AMD were enrolled. Retinal bivariate contour ellipse area (BCEA) obtained by microperimetry (Humphrey 10-2 68-loci grid) under mesopic conditions. Drusen type, drusenoid pigment epithelial detachment, hyperreflective foci (HF),...
Purpose: To evaluate visual acuity and contrast sensitivity after bilateral implantation of AcrySof® IQ ReSTOR® +2.50 D or +3.00 D. Methods: A total 56 eyes with cataract had a multifocal IOL. Inclusion criteria were corneal astigmatism less than 1.0 diopters, axial length between 22.0 24.0 mm, no associated ocular disease. Outcome measures recorded 12 months postoperatively binocular uncorrected corrected distance, intermediate near acuities, sensitivity. Postoperative quality life patient...
Purpose: The purpose of this study was to test whether functional loss in the glaucomatous macula is characterized by an enlargement Ricco's area (RA) through application a computational model linking retinal ganglion cell (RGC) damage perimetric sensitivity. Methods: One eye from each 29 visually healthy subjects <40 years old, 30 patients with glaucoma, and 20 age-similar controls tested 10-2 grid stimuli 5 different sizes. Structural estimates point-wise RGC density were obtained optical...
This study investigated the agreement of intraocular pressure measurements using rebound tonometry and applanation in response to atmospheric changes a hyperbaric chamber. Twelve eyes 12 healthy subjects were included this prospective, comparative, single-masked study. Intraocular performed by followed multiplace chamber at 1 Bar, 2, 3 4 Bar during compression again 2 decompression. Mean differences between 1.6, 1.7, 2.1 mmHg 3, respectively 2.6 2.2 Lower limits ranged from -3.7 -5.9 upper...
: To investigate macular vascular biomarkers for the detection of primary open-angle glaucoma (POAG).