A5054868218- Tendon Structure and Treatment
- Sports injuries and prevention
- Orthopedic Surgery and Rehabilitation
- Shoulder Injury and Treatment
- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Surgical Sutures and Adhesives
- Hydrogels: synthesis, properties, applications
- Wound Healing and Treatments
- Connective tissue disorders research
- Electrospun Nanofibers in Biomedical Applications
- Silk-based biomaterials and applications
- Musculoskeletal pain and rehabilitation
- Lower Extremity Biomechanics and Pathologies
- Head and Neck Surgical Oncology
- Knee injuries and reconstruction techniques
- biodegradable polymer synthesis and properties
- Muscle Physiology and Disorders
- Hemostasis and retained surgical items
- Immunotherapy and Immune Responses
- Foot and Ankle Surgery
- Gear and Bearing Dynamics Analysis
- Elasticity and Material Modeling
- Lymphadenopathy Diagnosis and Analysis
- Tribology and Lubrication Engineering
Beth Israel Deaconess Medical Center
2023-2024
Harvard University
2018-2024
University of Uyo
2024
Los Angeles Pierce College
2022
John Wiley & Sons (United States)
2022
University of Pennsylvania
2012-2021
Harvard College Observatory
2020
University of Rochester
2015
University of Illinois Chicago
1952
Illinois College
1952
Inspired by embryonic wound closure, we present mechanically active dressings to accelerate healing. Conventional passively aid healing maintaining moisture at sites. Recent developments have focused on drug and cell delivery drive a process, but these methods are often complicated side effects, sophisticated fabrication, high cost. Here, novel adhesive consisting of thermoresponsive tough hydrogels that combine stretchability, toughness, tissue adhesion, antimicrobial function. They adhere...
The development of tough adhesive hydrogels has enabled unprecedented adhesion to wet and moving tissue surfaces throughout the body, but they are typically composed nondegradable components. Here, a family degradable containing ≈90% water by incorporating covalently networked crosslinkers hydrolyzable ionically crosslinked main‐chain polymers is developed. Mechanical toughness, adhesion, degradation these new formulations tested in both accelerated vitro conditions up 16 weeks vivo. These...
Tissue adhesives capable of achieving strong and tough adhesion in permeable wet environments are useful many biomedical applications. However, generated through covalent bond formation directly with the functional groups tissues (i.e., COOH NH
Complete sequestration of central nervous system tissue and cerebrospinal fluid by the dural membrane is fundamental to maintaining homeostasis proper organ function, making reconstruction this layer an essential step during neurosurgery. Primary closure dura suture repair current standard, despite facing technical, microenvironmental, anatomic challenges. Here, we apply a mechanically tough hydrogel paired with bioadhesive for intraoperative sealing in rodent, porcine, human tissue. Tensile...
Abstract A covalently crosslinked methacrylated (MA)‐alginate cryogel vaccine has been previously shown to generate a potent response against murine melanoma, but is not mechanically robust and requires large 16G needle for delivery. Here, covalent ionic crosslinking of cryogels are combined with the hypothesis that this will result in tough MA‐alginate improved injectability. All can be injected through smaller, 18G without sustaining any damage, while crosslinked‐only break after...
This review highlights recent research on Achilles tendon healing, and comments the current clinical controversy surrounding diagnosis treatment of injury. The processes as demonstrated through changes in its structure, composition, biomechanics, are reviewed. Finally, a developmental biology mechano transductive pathways is completed to recognize efforts augment injured tendons, suggest potential future strategies for therapeutic intervention functional tissue engineering. Despite an...
This review highlights recent research onAchilles tendon healing, and comments on the current clinical controversy surrounding diagnosis treatment of injury.The processes Achilles as demonstrated through changes in its structure, composition, biomechanics, are reviewed.Finally, a developmental biology mechano transductive pathways is completed to recognize efforts augment injured tendons, suggest potential future strategies for therapeutic intervention functional tissue engineering.Despite...
Mechanical stimulation (mechanotherapy) can promote skeletal muscle repair, but a lack of reproducible protocols and mechanistic understanding the relation between mechanical cues tissue regeneration limit progress in this field. To address these gaps, we developed robotic device equipped with real-time force control compatible ultrasound imaging for strain analysis. We investigated hypothesis that specific loading improves repair by modulating inflammatory responses regulate regeneration....
Abstract Soft robotic technologies for therapeutic biomedical applications require conformal and atraumatic tissue coupling that is amenable to dynamic loading effective drug delivery or stimulation. This intimate sustained contact offers vast opportunities localized release. Herein, a new class of hybrid hydrogel actuator (HHA) facilitates enhanced introduced. The multi‐material soft can elicit tunable mechanoresponsive release charged from its alginate/acrylamide layer with temporal...
Abstract Following immunization, lymph nodes dynamically expand and contract. The mechanical cellular changes enabling the early-stage expansion of have been characterized, yet durability such responses their implications for adaptive immunity vaccine efficacy are unknown. Here, by leveraging high-frequency ultrasound imaging mice, we report more potent persistent lymph-node animals immunized with a mesoporous silica incorporating model antigen than given bolus immunization or standard...
Abstract Hydrogels are under active development for controlled drug delivery, but their clinical translation is limited by low loading capacity, deficiencies in mechanical toughness and storage stability, poor control over the release that often results burst short duration. This work reports a design of composite clay hydrogels, which simultaneously achieve spectrum mechanical, storage, loading/releasing properties to address critical needs from translational perspectives. The nanoparticles...
Abstract The extracellular matrix (ECM) is the primary biomechanical environment that interacts with tendon cells (tenocytes). Stresses applied via muscle contraction during skeletal movement transfer across structural hierarchies to tenocyte nucleus in native uninjured tendons. Alterations ECM and mechanical properties due loading tissue healing may affect this multiscale strain stress transmission through ECM. This study explores interface between dynamic multiple length scales using...
Achilles tendon ruptures are common and devastating injuries; however, an optimized treatment rehabilitation protocol has yet to be defined. Therefore, the objective of this study was investigate effects surgical repair return activity on joint function properties after 3 weeks healing. Sprague-Dawley rats (N = 100) received unilateral blunt transection their tendon. Animals were then randomized into repaired or non-repaired treatments, further groups that returned 1 week (RTA1) (RTA3) limb...
Abstract Multicellular spheroids made of stem cells can act as building blocks that fuse to capture complex aspects native in vivo environments, but the effect hydrogel viscoelasticity on cell migration from and their fusion remains largely unknown. Here, we investigated behavior mesenchymal (MSC) using hydrogels with a similar elasticity different stress relaxation profiles. Fast relaxing (FR) matrices were found be significantly more permissive consequent MSC spheroids. Mechanistically,...
Generating strong rapid adhesion between hydrogels has the potential to advance capabilities of modern medicine and surgery. Current hydrogel technologies rely primarily on liquid-based diffusion mechanisms formation covalent bonds, requiring prolonged time generate adhesion. Here, we present a simple versatile strategy using dry chitosan polymer films instant hydrogel–hydrogel hydrogel–elastomer surfaces. Using this approach can achieve extremely high adhesive energies (>3,000 J/m 2 ),...
Medical adhesives are emerging as an important clinical tool adjuvants for sutures and staples in wound closure healing the achievement of hemostasis. However, combining cytocompatibility, well strong stable adhesion physiological conditions, still demand. Herein, a mussel-inspired strategy is explored to produce adhesive coacervates using tannic acid (TA) methacrylate pullulan (PUL-MA). TA|PUL-MA mainly comprise van der Waals forces hydrophobic interactions. The methacrylic groups PUL...
Abstract Surgical sutures are gold‐standard wound closure devices. However, they unable to form a tight seal with surrounding tissues, raising the risks of body fluid leakage and surgical site infection. Additionally, use can result in cracking at suture roots, damage micro‐trauma soft tissues due slicing compression fibers after their placement. Bioadhesives capable mimicking natural biological interfaces appealing alternatives, but cannot achieve same level strength as conventional...
Collagen V mutations underlie classic Ehlers-Danlos syndrome, and joint hypermobility is an important clinical manifestation. We define the function of collagen in tendons ligaments, as well role alterations expression pathobiology syndrome. A conditional Col5a1(flox/flox) mouse model was bred with Scleraxis-Cre mice to create a targeted tendon ligament Col5a1-null model, Col5a1(Δten/Δten). Targeting specific, resulting V-null ligaments. Col5a1(Δten/Δten) demonstrated decreased body size,...