A5029039106- Magnetic Properties and Synthesis of Ferrites
- 3D Printing in Biomedical Research
- Surgical Sutures and Adhesives
- Hydrogels: synthesis, properties, applications
- Advanced Sensor and Energy Harvesting Materials
- Electromagnetic wave absorption materials
- Polymer Surface Interaction Studies
- Cellular Mechanics and Interactions
- Multiferroics and related materials
- Magnetic Properties and Applications
- Electrospun Nanofibers in Biomedical Applications
- Shoulder Injury and Treatment
- Blood properties and coagulation
- Advancements in Battery Materials
- Hemostasis and retained surgical items
- Microwave Dielectric Ceramics Synthesis
- Conducting polymers and applications
- Bone fractures and treatments
- Ferroelectric and Piezoelectric Materials
- Platelet Disorders and Treatments
- Pregnancy and preeclampsia studies
- Tendon Structure and Treatment
- Magneto-Optical Properties and Applications
- Genetics, Bioinformatics, and Biomedical Research
- Advancements in Transdermal Drug Delivery
McGill University
2016-2024
University of British Columbia
2023-2024
Harvard University
2024
Tsinghua University
1999-2005
State Key Laboratory of New Ceramics and Fine Processing
2000-2003
Materials Science & Engineering
2001
Tough bioadhesion has important implications in engineering and medicine but remains challenging to form control. We report an ultrasound (US)-mediated strategy achieve tough with controllability fatigue resistance. Without chemical reaction, the US can amplify adhesion energy interfacial threshold between hydrogels porcine skin by up 100 10 times. Combined experiments theoretical modeling suggest that key mechanism is US-induced cavitation, which propels immobilizes anchoring primers into...
Non-compressible hemorrhage is an unmet clinical challenge that accounts for high mortality in trauma. Rapid pressurized blood flows under impair the function and integrity of hemostatic agents adhesion bioadhesive sealants. Here, we report design performance bioinspired microstructured bioadhesives, formed with a macroporous tough xerogel infused functional liquids. The can rapidly absorb interfacial fluids such as whole promote clotting, while liquids facilitate bonding, sealing,...
Cell-laden scaffolds of architecture and mechanics that mimic those the host tissues are important for a wide range biomedical applications but remain challenging to bioprint. To address these challenges, we report new method called triggered micropore-forming bioprinting. The approach can yield cell-laden defined interconnected pores over sizes, encompassing many cell types. viscoelasticity bioprinted scaffold match biological be tuned independently porosity stiffness. also exhibits...
A bioinspired surface functionalization strategy is proposed to fabricate sutures with robust hydrogel sheath multifunctions.
Tissue-mimetic hybrid bioadhesives for the repair of intervertebral disc after nucleotomy is proposed, comprising a viscoelastic glue delivering cells to fill cavity and tough adhesive sealant prevent re-herniation post-nucleotomy.
Abstract Surgical sutures are gold‐standard wound closure devices. However, they unable to form a tight seal with surrounding tissues, raising the risks of body fluid leakage and surgical site infection. Additionally, use can result in cracking at suture roots, damage micro‐trauma soft tissues due slicing compression fibers after their placement. Bioadhesives capable mimicking natural biological interfaces appealing alternatives, but cannot achieve same level strength as conventional...
Abstract Emerging soft ionotronics better match the human body mechanically and electrically compared to conventional rigid electronics. They hold great potential for human‐machine interfaces, wearable implantable devices, machines. Among various ionotronic ionic junctions play critical roles in rectifying currents as electrical p–n junctions. Existing junctions, however, are limited mechanical performance, difficult fabricate degrade. Herein, design, fabrication, characterization of tough...
Abstract The syncytiotrophoblast is a multinucleated layer that plays critical role in regulating functions of the human placenta during pregnancy. Maintaining relies on ongoing fusion mononuclear cytotrophoblasts throughout pregnancy, and errors this process are associated with complications such as preeclampsia. While biochemical factors known to drive fusion, disease-specific extracellular biophysical cues remains undefined. Since substrate mechanics play crucial several diseases,...
Abstract Adhesives can intimately connect humans to machines, seamlessly bond diverse tissues in the human body, and manage various diseases. However, precise spatial control of wet tough adhesion biocompatible hydrogels on biological remains a major challenge. Inspired by bioglue secreted sandcastle worms, design printable adhesives (PTAs) is proposed, supramolecular hydrogel that be printed into defined structures, situ mechanically reinforced matrix with physiologically relevant benign...
Ionotronic hydrogels find wide applications in flexible electronics, wearable/implantable devices, soft robotics, and human-machine interfaces. Their performance practical translation have been bottlenecked by poor adhesiveness, limited mechanical properties, the lack of biological functions. The remedies are often associated with complex formulations sophisticated processing. Here, we report a rational design facile synthesis ionotronic tough adhesives (i-TAs), which excellent mechanical,...
The mechanical properties of sutures are important for wound closure and meniscus repair. A tough gel coating technology has been developed to modify functionalize sutures, but its effects on suture degradation remain unexplored. Our aim is investigate how a mediates the suture. Polyglactin910 (Vicryl) was chosen because it widely used, strong, easy handle, degradable. This study compared six pristine Vicryl coated at 0, 2, 4, 6 weeks. All were soaked in phosphate-buffered saline (PBS),...
Magnetically anchored microboats that can reliably and rapidly create air–liquid interface culture conditions in substrate-stiffness tunable epithelial cell cultures.
The placental syncytiotrophoblast is a giant multinucleated cell that forms tree-like structure and regulates transport between mother baby during development. It maintained throughout pregnancy by continuous fusion of trophoblast cells, disruptions in are associated with considerable adverse health effects including diseases such as preeclampsia. Developing predictive control over culture models hence critical importance drug discovery studies, but this can currently be only partially...
Robust tough bioadhesion and enhanced locoregional drug delivery mediated by penetration enhancers.
Abstract Purpose To test tough gel adhesives to repair meniscus tears under relevant loading conditions and determine if they have adequate biomechanical properties in a bovine cadaveric study. Methods Cyclic compression tests on 24 dissected knees were performed. The adhesive was used either as an patch or coating bonded onto commercially available surgical sutures. Forty‐eight menisci tested this study; complete radial bucket‐handle tears. After preconditioning, the specimens underwent 100...