A5001849498- Hemostasis and retained surgical items
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Trauma and Emergency Care Studies
- Gastrointestinal Bleeding Diagnosis and Treatment
- Hemoglobin structure and function
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- Pelvic and Acetabular Injuries
- COVID-19 and healthcare impacts
- Biomedical and Engineering Education
- Polymer Surface Interaction Studies
- Viral Infections and Immunology Research
- Gastrointestinal Tumor Research and Treatment
- Blood transfusion and management
- Hemophilia Treatment and Research
- 3D Printing in Biomedical Research
- Advanced biosensing and bioanalysis techniques
- Animal Virus Infections Studies
- Abdominal Trauma and Injuries
- Disaster Response and Management
- Surgical Sutures and Adhesives
University of British Columbia
2019-2025
Canada's Michael Smith Genome Sciences Centre
2019-2025
Upsher-Smith Laboratories (United Kingdom)
2023
Medical College of Wisconsin
2022
Harborview Medical Center
2022
Non-compressible hemorrhage is an unmet clinical challenge that accounts for high mortality in trauma. Rapid pressurized blood flows under impair the function and integrity of hemostatic agents adhesion bioadhesive sealants. Here, we report design performance bioinspired microstructured bioadhesives, formed with a macroporous tough xerogel infused functional liquids. The can rapidly absorb interfacial fluids such as whole promote clotting, while liquids facilitate bonding, sealing,...
Trauma-induced hemorrhage is the leading cause of preventable death on battlefield, with anatomical junctional wounds accounting for ∼19% deaths. This highlights need effective control interventions. Consequently, CounterFlow-Gauze was developed to deliver thrombin, tranexamic acid (TXA), and calcium through a self-propelling acid-base reaction, eliminating manual compression. study evaluates usability efficacy Committee Tactical Combat Casualty Care standard care, Gauze. Ten Canadian Armed...
delivery of mRNA is promising for the study gene expression and treatment diseases. Lipid nanoparticles (LNPs) enable efficient constructs, but protein has been assumed to be limited liver. With specialized LNPs, extrahepatic tissue occurs in small animal models; however, it unclear if global all major organs possible humans because may affected by differences innate immune response relative organ size. Furthermore, studies with LNPs have performed large models, such as swine, due their...
Abstract Background and study aims Hemostatic powders have emerged recently to treat upper gastrointestinal bleeding (UGIB). Previously, we developed a novel self-propelling thrombin powder (SPTP) that effectively manages external pulsatile arterial bleed without compression, by effervescing carrying into the wound. Here, tested if SPTP, sprayed endoscopically, can manage severe UGIB in live porcine model. Materials methods Anesthetized pigs underwent laparotomy insert gastroepiploic...
Noncompressible truncal hemorrhage (NCTH) remains a leading cause of preventable death on the battlefield. Definitively managing severe NCTH requires surgery within first hour after injury, which is difficult when evacuating casualties from remote and austere environments. During delays to surgery, hemostatic interventions that are performed prehospital can prevent coagulopathy hemorrhagic shock increase likelihood survive receive definitive care. We previously reported self-propelling...
Hemorrhage is responsible for 91% of preventable prehospital deaths in combat. Bleeding from anatomic junctions such as the groin, neck, and axillae make up 19% these deaths, reports estimate that effective control junctional hemorrhage could have prevented 5% fatalities Afghanistan. Hemostatic dressings are but time-consuming to apply limited when proper packing manual pressure not feasible, during care under fire. CounterFlow-Gauze a hemostatic dressing without compression delivers...
Genetic manipulation of animal models is a fundamental research tool in biology and medicine but challenging large animals. In rodents, can be readily developed by knocking out genes embryonic stem cells or down through vivo delivery nucleic acids. Swine are preferred model for studying the cardiovascular immune systems, there limited strategies genetic manipulation. Lipid nanoparticles (LNPs) efficiently deliver small interfering RNA (siRNA) to knock circulating proteins, swine sensitive...
LAY SUMMARY The efficacy of current hemostatic technologies is limited by several factors. Outward blood flow washes drugs away from the wound, and often require focus, training, time to use correctly, are highly specific one type injury, or pose severe safety risks. CounterFlow a novel product that could potentially save military civilian lives stopping heavy bleeding variety organs other bodily locations technology cannot easily treat. Upon contact with blood, releases bursts gas safely...
ABSTRACT Introduction COVID-19 shutdowns in many research facilities across North America impacted preclinical trauma-related and development. Shutdown limited the speed resources available for large animal experiments necessary advancing medical devices technologies. However, pandemic led to rapid adoption expansion of videoconferencing social circles, workplaces, primary care health settings. Here, we describe use simple equipment plan carry out 3 total weeks with a large, cross-continent,...