A5056835981- Advanced Sensor and Energy Harvesting Materials
- Hydrogels: synthesis, properties, applications
- Electrospun Nanofibers in Biomedical Applications
- Polymer Surface Interaction Studies
- Advanced Drug Delivery Systems
- Nanocomposite Films for Food Packaging
- Protease and Inhibitor Mechanisms
- 3D Printing in Biomedical Research
- Conducting polymers and applications
- Polysaccharides Composition and Applications
- Advanced Cellulose Research Studies
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Hemostasis and retained surgical items
- Adhesion, Friction, and Surface Interactions
- Immune cells in cancer
- Dielectric materials and actuators
- Luminescence and Fluorescent Materials
- Laser-Ablation Synthesis of Nanoparticles
- Tissue Engineering and Regenerative Medicine
- Immunotherapy and Immune Responses
- Musculoskeletal pain and rehabilitation
- Advanced Materials and Mechanics
- Surgical Sutures and Adhesives
- Silk-based biomaterials and applications
McGill University
2021-2024
Soochow University
2017-2019
Suzhou Research Institute
2019
Tough bioadhesion has important implications in engineering and medicine but remains challenging to form control. We report an ultrasound (US)-mediated strategy achieve tough with controllability fatigue resistance. Without chemical reaction, the US can amplify adhesion energy interfacial threshold between hydrogels porcine skin by up 100 10 times. Combined experiments theoretical modeling suggest that key mechanism is US-induced cavitation, which propels immobilizes anchoring primers into...
Non-compressible hemorrhage is an unmet clinical challenge that accounts for high mortality in trauma. Rapid pressurized blood flows under impair the function and integrity of hemostatic agents adhesion bioadhesive sealants. Here, we report design performance bioinspired microstructured bioadhesives, formed with a macroporous tough xerogel infused functional liquids. The can rapidly absorb interfacial fluids such as whole promote clotting, while liquids facilitate bonding, sealing,...
An antibiotic-free and regenerable antibacterial hybrid film with both photothermal bactericidal activity bacteria-releasing properties is fabricated on diverse substrates.
Low back pain is a leading cause of disability worldwide, often attributed to intervertebral disc (IVD) degeneration with loss the functional nucleus pulposus (NP). Regenerative strategies utilizing biomaterials and stem cells are promising for NP repair. Human tissue highly viscoelastic, relaxing stress rapidly under deformation. However, impact tissue-specific viscoelasticity on activities adipose-derived (ASC) remains largely unexplored. Here, we investigated role matrix in regulating ASC...
Abstract Emerging soft ionotronics better match the human body mechanically and electrically compared to conventional rigid electronics. They hold great potential for human‐machine interfaces, wearable implantable devices, machines. Among various ionotronic ionic junctions play critical roles in rectifying currents as electrical p–n junctions. Existing junctions, however, are limited mechanical performance, difficult fabricate degrade. Herein, design, fabrication, characterization of tough...
Abstract Surface modification with bioactive agents capable of combating thrombosis is a widely used strategy for developing antithrombotic biomaterials. However, exposure the blood to agent on material surface may cause hemostatic disorders under normal conditions. Ideally an implanted biomaterial should respond appropriately demand specific change in physiologic environment, as happens body itself. In present study, thrombosis‐responsive coating ability lyse fibrin it forms reported. The...
Efficient intracellular delivery of exogenous macromolecules is a key operation in biological research and for clinical applications. Moreover, under particular vitro or ex vivo conditions, harvesting the engineered cells that maintain good viability also important. However, none methods currently available truly satisfactory all respects. Herein, "two-in-one" platform based on polydopamine/poly( N-isopropylacrylamide) (PDA/PNIPAAm) hybrid film developed, showing high efficiency both cargo...
Hydrogel adhesion that can be easily modulated in magnitude, space, and time is desirable many emerging applications ranging from tissue engineering soft robotics to wearable devices. In synthetic materials, these complex behaviors are often achieved individually with mechanisms apparatus difficult integrate. Here, we report a universal strategy embody multifaceted programmability hydrogels. By designing the surface network topology of hydrogel, supramolecular linkages result contrasting...
The "self-homing" of cancer cells to primary or metastatic tumor sites indicates that they could serve as vehicles for self-targeted therapy; this suggests a promising method treating end-stage cancer. Inspired by this, we propose engineering carry efficient "coup" molecules in situ activation immune near attack tumors is strategy therapy. Therefore, herein explored the potential engineered enhance their anticancer activity stimulating cells. We armed cell surfaces with specific...
Marine biomass waste is a remarkable source of functional molecules and materials.
Ionotronic hydrogels find wide applications in flexible electronics, wearable/implantable devices, soft robotics, and human-machine interfaces. Their performance practical translation have been bottlenecked by poor adhesiveness, limited mechanical properties, the lack of biological functions. The remedies are often associated with complex formulations sophisticated processing. Here, we report a rational design facile synthesis ionotronic tough adhesives (i-TAs), which excellent mechanical,...
Chitin nanocrystals (ChNCs) are unique to all other bio-derived nanomaterials in one aspect: the inherent presence of a nitrogen moiety. By tuning chemical functionality this nanomaterial, and thus its charge hydrogen bonding capacity, can heavily impact macroscopic properties such as rheological self-assembly characteristics. In study, two types ChNCs made using acid hydrolysis (AH-ChNCs) oxidative (OX-ChNCs) pathways, unto which deacetylation solvent-free procedure is utilized create...
GAG-mimicking polymers were prepared by a novel method allowing close control of structure and can be used as potent synthetic bioactive modifiers to promote endothelialization materials.
In this article, we demonstrate a new and clean method for the fabrication of chitosan nanocrystals relying on aging. We provide metrics to showcase greeness method. are then using these materials as building block fabricate alginate hydrogels, demonstrated that they have superior properties gelation drug release.
Hydrogel adhesion that can be easily modulated in magnitude, space, and time is desirable many emerging applications ranging from tissue engineering, soft robotics, to wearable devices. In synthetic materials, these complex behaviors are often achieved individually with mechanisms apparatus difficult integrate. Here, we report a universal strategy embody multifaceted programmability hydrogels. By designing the surface network topology of hydrogel, supramolecular linkages result contrasting...
Chitin nanocrystals (ChNCs) are unique to all other bio-derived nanomaterials in one aspect: the inherent presence of a nitrogen moiety. By tuning chemical functionality this nanomaterial, and thus its charge hydrogen bonding capacity, can heavily impact macroscopic properties such as rheological self-assembly characteristics. In study, two types ChNCs made using acid hydrolysis (AH-ChNCs) oxidative (OX-ChNCs) pathways, unto which deacetylation solvent-free procedure is utilized create...
Low back pain is a leading cause of disability worldwide, often attributed to intervertebral disc (IVD) degeneration with loss the functional nucleus pulposus (NP). Regenerative strategies utilizing biomaterials and stem cells are promising for NP repair. Human tissue highly viscoelastic, relaxing stress rapidly under deformation. However, impact tissue-specific viscoelasticity on activities adipose-derived (ASC) remains largely unexplored. Here, we investigated role matrix in regulating ASC...
Ionotronics An hourglass measures time by a regulated flow of sand through narrow neck. In article number 2213677, Jianyu Li and co-workers show that with similar shapes, ionic junctions regulate ion flow, allowing unidirectional current conduction. Like in an hourglass, microgels can be the building blocks such ionotronics to achieve printability tough mechanics. The are critical elements world soft stretchable circuits. Cover illustration SciFig (Mitra, Aram, Farzan; https://sci-fig.com/).
In article number 1703934, Dan Li, Hong Chen, and co-workers report a novel thrombolytic coating whose activity is triggered by thrombosis. The coated surfaces remain inert in normal plasma environment while releasing tissue plasminogen activator (t-PA) promoting fibrinolysis response to thrombin. Such could avoid unfavorable complications caused continuous release of antithrombotic agents.
In this article, we demonstrate a new and clean method for the fabrication of chitosan nanocrystals relying on aging. We provide metrics to showcase greeness method. are then using these materials as building block fabricate alginate hydrogels, demonstrated that they have superior properties gelation drug release.<br>