A5002381283- Advanced NMR Techniques and Applications
- Cardiomyopathy and Myosin Studies
- Advanced Drug Delivery Systems
- Hydrogels: synthesis, properties, applications
- Nanomaterials for catalytic reactions
- Electron Spin Resonance Studies
- Signaling Pathways in Disease
- Cardiovascular Function and Risk Factors
- Catalysis and Hydrodesulfurization Studies
- NMR spectroscopy and applications
- Silicon Nanostructures and Photoluminescence
- Silicon Carbide Semiconductor Technologies
- Cardiac Structural Anomalies and Repair
- Cardiac electrophysiology and arrhythmias
- Medical Imaging Techniques and Applications
- Supramolecular Chemistry and Complexes
- Fluorine in Organic Chemistry
- Bone health and treatments
- GaN-based semiconductor devices and materials
- Carbon and Quantum Dots Applications
- Carbon dioxide utilization in catalysis
- Antimicrobial Resistance in Staphylococcus
- Advanced Battery Technologies Research
- Chemical Synthesis and Reactions
- Luminescence Properties of Advanced Materials
Sandia National Laboratories
2023
University of Alberta
2018-2022
Alberta Hospital Edmonton
2021
The design of new materials requires a deep understanding the intricacies underpinning their structure–property relationships. These relationships are modified through synthesis and processing to create with properties characteristics achieve wide range applications. With entirety periodic table at one's fingertips, unique microstructure each these is often challenging. One technique that expanding robust ability solid-state nuclear magnetic resonance (NMR) spectroscopy delve into details...
Marine biomass waste is a remarkable source of functional molecules and materials.
The development of calcium sensitizers for the treatment systolic heart failure presents difficulties, including judging optimal efficacy and specificity to target cardiac muscle. thin filament is an attractive because troponin C (cTnC) site binding trigger subsequent contraction. One widely studied sensitizer levosimendan. We have recently shown that when a covalent cTnC-levosimendan analogue exchanged into muscle cells, they become constitutively active, demonstrating potency complex. also...
Doped silicon nanocrystals (SiNCs) are promising materials that could find use in a wide variety of applications. Realizing methods to tailor the surface chemistry these particles offers greater tunability material properties as well broader solvent compatibility. Herein, we report organic-soluble B-doped SiNCs prepared via thermal processing method followed by phosphorous pentachloride etching induced functionalization with alkoxy ligands varied chain lengths. This approach provides...
We have investigated the mechanism and reactivity of covalent bond formation between cysteine-84 regulatory domain cardiac troponin C compounds containing a nitrile moiety similar to calcium sensitizer levosimendan. The results modifications levosimendan framework ranged from large increase in complete inactivity. present biological activity one most potent compounds. Limitations, including compound solubility degradation at acidic pH, prevented thorough investigation potential these Our...
Heart muscle contraction is regulated by calcium binding to cardiac troponin C. This induces I (cTnI) switch region the regulatory domain of C (cNTnC), pulling cTnI inhibitory off actin and triggering contraction. Small molecules targeting this cNTnC-cTnI interface have potential in treatment heart disease. Most these an aromatic core which binds hydrophobic cNTnC, a polar often charged 'tail'. The calmodulin antagonist W7 unique that it acts as desensitizer. cNTnC weakens binding, possibly...
We report the solid-state <sup>17</sup>O NMR parameters for five previously uncharacterized <italic>N</italic>-α-fluoren-9-yl-methoxycarbonyl-<italic>O-t</italic>-butyl (Fmoc) protected amino acids.
Compounds that directly modulate the response of cardiac sarcomere have potential in treatment disease. While a number activators been discovered and extensively studied, very few inhibitors identified. We report potent inhibitor, DN-F01, targeting muscle thin filament protein troponin complex. Functional studies show DN-F01 has strong inhibitory calcium-dependent effect on myofibrillar ATPase activity with an IC50 value 11 ± 4 nmol/L. is shown to bind C-troponin I chimera (cChimera) K D ∼50...
In this article, we demonstrate a new and clean method for the fabrication of chitosan nanocrystals relying on aging. We provide metrics to showcase greeness method. are then using these materials as building block fabricate alginate hydrogels, demonstrated that they have superior properties gelation drug release.
We report on AlGaN HEMT-based logic development, using combined enhancement- and depletion-mode transistors to fabricate inverters with operation from room temperature up 500°C. Our development approach included: (a) characterizing dependent carrier transport for different HEMT heterostructures, (b) developing a suitable gate metal scheme use in high temperatures, (c) over-temperature testing of discrete devices inverters. Hall mobility data revealed the GaN-channel experienced 6.9×...
Abstract Petroleum is one of the most important natural resources for human beings, while contained sulfur heteroatoms lead to a series problems1. Therefore, desulfurization process reduce content mandatory clean petroleum utilization. Hydrodesulfurization currently mature in industry, this costly, energy intensive and environmentally unfriendly due CO2 emission H2S production2,3. Alternative cost-effective with benign sulfur-containing products remains unreported. Here we demonstrate that...
In this article, we demonstrate a new and clean method for the fabrication of chitosan nanocrystals relying on aging. We provide metrics to showcase greeness method. are then using these materials as building block fabricate alginate hydrogels, demonstrated that they have superior properties gelation drug release.<br>