A5009342779- Immunotherapy and Immune Responses
- Neural dynamics and brain function
- vaccines and immunoinformatics approaches
- Functional Brain Connectivity Studies
- Neural Networks and Applications
- EEG and Brain-Computer Interfaces
- Memory and Neural Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Cytomegalovirus and herpesvirus research
- Sleep and Work-Related Fatigue
- Diabetes Management and Research
- Urticaria and Related Conditions
- Herpesvirus Infections and Treatments
- Drug-Induced Adverse Reactions
- Dermatology and Skin Diseases
- Sleep and Wakefulness Research
- Optical Imaging and Spectroscopy Techniques
- Advanced Memory and Neural Computing
- Dermatological diseases and infestations
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Advanced MRI Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- Food Allergy and Anaphylaxis Research
- Sarcoidosis and Beryllium Toxicity Research
McGill University Health Centre
2024-2025
Princeton University
2023-2024
Concordia University
2019-2024
Institut Universitaire de Gériatrie de Montréal
2020-2024
Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal
2020-2024
William Carey University
2024
Neuroscience Institute
2023-2024
McGill University
2019-2024
Yale University
2023
Insulet (United States)
2021-2023
Abstract Surgical sutures are gold‐standard wound closure devices. However, they unable to form a tight seal with surrounding tissues, raising the risks of body fluid leakage and surgical site infection. Additionally, use can result in cracking at suture roots, damage micro‐trauma soft tissues due slicing compression fibers after their placement. Bioadhesives capable mimicking natural biological interfaces appealing alternatives, but cannot achieve same level strength as conventional...
Abstract Evidence obtained from both animal models and humans suggests that T cells specific for HSV-1 HSV-2 glycoprotein D (gD) contribute to protective immunity against herpes infection. However, knowledge of gD-specific human cell responses is limited CD4+ epitopes, with no CD8+ epitopes identified date. In this study, we screened the gD amino acid sequence HLA-A*0201-restricted using several predictive computational algorithms 10 high probability epitopes. Synthetic peptides...
Sleep deprivation leads to significant impairments in cognitive performance and changes the interactions between large scale cortical networks, yet hierarchical organization of activity across states is still being explored. We used functional magnetic resonance imaging assess activations connectivity during tasks 20 healthy young adults, three states: (i) following a normal night sleep, (ii) 24hr total sleep deprivation, (iii) after morning recovery nap. Situating along organizing gradients...
We present MindEye, a novel fMRI-to-image approach to retrieve and reconstruct viewed images from brain activity. Our model comprises two parallel submodules that are specialized for retrieval (using contrastive learning) reconstruction diffusion prior). MindEye can map fMRI activity any high dimensional multimodal latent space, like CLIP image enabling using generative models accept embeddings this space. comprehensively compare our with other existing methods, both qualitative side-by-side...
Chronic pain in pediatric populations presents a multifaceted challenge with biopsychosocial impact, requiring multidisciplinary approach including psychological treatment. At our interdisciplinary center, the SARS-CoV-2 pandemic-related disruptions led to cessation of cognitive-behavioral therapy (CBT) and other interventions during pandemic. The aim this retrospective cohort study secondary matched case-control analysis was evaluate impact interruption non-CBT interventions, namely...
What determines when neural representations of memories move together (integrate) or apart (differentiate)? Classic supervised learning models posit that, two stimuli predict similar outcomes, their should integrate. However, these have recently been challenged by studies showing that pairing with a shared associate can sometimes cause differentiation, depending on the parameters study and brain region being examined. Here, we provide purely unsupervised network model explain other related...
When you perceive or remember something, other related things come to mind, affecting how these competing items are subsequently perceived and remembered. Such behavioural consequences believed result from changes in the overlap of neural representations items, especially hippocampus. According multiple theories, hippocampal should increase (integration) when there is high coactivation between cortical representations. However, prior studies used indirect proxies for by manipulating stimulus...
Systemic delivery of therapeutics into the brain is greatly impaired by multiple biological barriers─the blood–brain barrier (BBB) and extracellular matrix (ECM) space. To address this problem, we developed a combinatorial approach to identify peptides that can shuttle transport across both barriers. A cysteine-constrained heptapeptide M13 phage display library was iteratively panned against an established BBB model for three rounds select barrier. Using next-generation DNA sequencing in...
Sleep deprivation (SD) leads to impairments in cognitive function. Here, we tested the hypothesis that changes sleep-deprived brain can be explained by information processing within and between large-scale cortical networks. We acquired functional magnetic resonance imaging (fMRI) scans of 20 healthy volunteers during attention executive tasks following a regular night sleep, SD, recovery nap containing nonrapid eye movement (NREM) sleep. Overall, SD was associated with increased cortex-wide...
Automated insulin delivery (AID) systems, which connect an pump, continuous glucose monitoring system, and software algorithm to automate based on real-time glycemic data, hold promise for improving outcomes reducing therapeutic burden people with diabetes. This article reviews the features of Omnipod 5 Insulin Delivery System how it compares other AID systems available or currently under review U.S. market. It also provides practical guidance clinicians effectively train onboard diabetes...
What determines when neural representations of memories move together (integrate) or apart (differentiate)? Classic supervised learning models posit that, two stimuli predict similar outcomes, their should integrate. However, these have recently been challenged by studies showing that pairing with a shared associate can sometimes cause differentiation, depending on the parameters study and brain region being examined. Here, we provide purely unsupervised network model explain other related...
We showed that pomegranate juice (PomJ) can help to maintain memory in adults aged >50 y. The mechanism for this effect is unknown, but might involve Trp and its metabolites, which are important brain function.
Abstract Simultaneous recording of electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) is a very promising non‐invasive neuroimaging technique. However, EEG data obtained from the simultaneous EEG–fMRI are strongly influenced by MRI‐related artefacts, namely gradient artefacts (GA) ballistocardiogram (BCG) artefacts. When compared to GA correction, BCG correction more challenging remove due its inherent variabilities dynamic changes over time. The standard (i.e.,...
Patient-specific heart and valve models have shown promise as training planning tools for surgery, but physically realistic remain elusive. Available proprietary, simulation-focused are generic adult mitral valves do not allow patient-specific modeling may be needed rare diseases such congenitally abnormal valves. We propose creating silicone from a 3D-printed plastic mold solution that can adapted to any individual patient at fraction of the cost direct 3D-printing using soft...
Objective Chiropractic, as a business in the health care system, has component of entrepreneurship. Therefore, it is important to have education chiropractic schools. This study examines perceptions schools evaluated by Ontario, Canada, practicing chiropractors. Methods We conducted series interviews with 16 chiropractors Ontario. Questions aimed at analyzing 2 levels chiropractors' on quality they received. The questions were designed around concepts: perceived level knowledge acquired and...
Abstract Simultaneous recording of electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) is a widely used non-invasive neuroimaging technique in sleep studies. However, EEG data are strongly influenced by two types MRI-related artefacts: gradient artefacts (GA) ballistocardiogram (BCG). If correction suboptimal, the BCG obscures signals below 20Hz could make it difficult to investigate oscillations, especially spindles, specific oscillations occurring within 11-16Hz...
Chronic idiopathic ulcers of the colon pose diagnostic challenges due to their elusive etiology and potential resemblance other intestinal pathologies, such as cecal carcinoma. This case report outlines clinical course a 68-year-old female patient who presented emergency department (ED) with persistent right lower quadrant pain. Despite multiple hospital visits yielding varied diagnoses, definitive diagnosis was only made following laparoscopic partial colectomy, which revealed chronic...
Decrease in cognitive performance after sleep deprivation followed by recovery suggests its key role, and especially non-rapid eye movement (NREM) sleep, the maintenance of cognition. It remains unknown whether brain network reorganization NREM stages N2 N3 can uniquely be mapped onto individual differences a nap following deprivation. Using resting state functional magnetic resonance imaging (fMRI), we quantified integration segregation networks during while participants took 1-hour 24-hour...