A5014992947- Schizophrenia research and treatment
- Musculoskeletal pain and rehabilitation
- Genomic variations and chromosomal abnormalities
- Genetic Associations and Epidemiology
- Motor Control and Adaptation
- Substance Abuse Treatment and Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Transcranial Magnetic Stimulation Studies
- Mental Health Treatment and Access
- Patient Safety and Medication Errors
- Muscle activation and electromyography studies
- Genetics and Neurodevelopmental Disorders
- Mental Health and Patient Involvement
- Community Health and Development
- Dementia and Cognitive Impairment Research
- Primary Care and Health Outcomes
- Bipolar Disorder and Treatment
- Healthcare Technology and Patient Monitoring
- Cannabis and Cannabinoid Research
- Ergonomics and Musculoskeletal Disorders
- Celiac Disease Research and Management
- Botulinum Toxin and Related Neurological Disorders
- Multisensory perception and integration
- Aortic aneurysm repair treatments
- Effects of Vibration on Health
University of Ontario Institute of Technology
2010-2024
University Maternity Hospital Limerick
2019
Tallaght University Hospital
1987-2019
St. Vincent's University Hospital
2019
University of Ottawa
2018
Bruyère
2018
The University of Melbourne
2011-2013
Orygen Youth Health
2011
University of Auckland
2006-2008
Murphy Oil Corporation (United States)
2004-2007
This study was an attempt to replicate evidence for a vulnerability locus schizophrenia and associated disorders in the 8p22-21 region reported by Pulver colleagues.The linkage sample of Irish Study High-Density Schizophrenia Families consists 265 multiplex families containing 1,408 individuals. Fifteen markers covering 30 centimorgans on chromosome 8p were tested. Three statistical methods used: two-point multipoint heterogeneity lod scores nonparametric test.According scores, strongest...
We report three new mutations in patients with myophosphorylase deficiency (McArdle disease). A splice-junction mutation (G-to-A transition at the 5' end of intron 14) and a missense (CTG to CCG codon 291, changing an encoded leucine proline) were identified Caucasian who heterozygous for common reported elsewhere (CGA [Arg] TGA [stop]) 49. The destroyed consensus sequence splice site, cryptic site 67 bp upstream was recognized instead. As result, there 67-bp deletion 3'-terminal region exon...
BACKGROUND Intestinal morphology and function vary geographically. AIMS These functions were assessed in asymptomatic volunteers European, North American, Middle Eastern, Asian, African, Caribbean countries. METHODS Five hour urine collections obtained from each subject following ingestion of a 100 ml iso-osmolar test solution containing 3–0-methyl- d -glucose, -xylose, l -rhamnose, lactulose after an overnight fast, to assess active (3–0-methyl- -glucose) passive ( -xylose) carrier...
OBJECTIVE: Schizophrenia is clinically heterogeneous. Recent linkage studies suggest that multiple genes are important in the etiology of schizophrenia. The authors examined hypothesis whether clinical variability schizophrenia due to genetic heterogeneity. METHOD: Using data from Irish Study High-Density Families (N=265 pedigrees; N=1,408 individuals), attempted predict, major symptoms and signs psychosis, evidence for within families schizophrenia-related disorders chromosomal regions...
Large samples of multiplex pedigrees will probably be needed to detect susceptibility loci for schizophrenia by linkage analysis. Standardized ascertainment such from culturally and ethnically homogeneous populations may improve the probability detection replication linkage. The Irish Study High-Density Schizophrenia Families (ISHDSF) was formed standardized families in 39 psychiatric facilities covering over 90% population Ireland Northern Ireland. We here describe a phenotypic sample...
The objective of this study was to determine differences in electromyographic (EMG) activity prime mover and abdominal muscles while performing squats, push ups, double leg lowering with a swiss ball. Twelve healthy subjects performed the movements. There no difference between surface conditions for muscle during squat exercise; however, individuals had lower perceived exertion ball squat. Activity triceps abdominals highest ups on ball, whereas rectus abdominus (RA) only increased Perceived...
No AccessJournal of Urology1 Sep 1987Experimental Partial Ureteric Obstruction: Pathophysiological Changes in Upper Tract Pressures and Renal Blood Flow P.C. Ryan, K.P. Maher, B. Murphy, G.D. Hurley, J.M. Fitzpatrick RyanP.C. Ryan More articles by this author , MaherK.P. Maher MurphyB. Murphy HurleyG.D. Hurley FitzpatrickJ.M. View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)43297-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints...
In Brief Study Design. Pre and post 12-week training study using surface electromyography to measure the flexion relaxation response. Objective. To evaluate whether active or passive phases of measurement changes following an exercise intervention in patients with low back pain. Summary Background Data. Impaired neuromuscular activation is area specific interest chronic nonspecific pain (LBP). The phenomenon commonly measured LBP patients; however, there insufficient evidence about this...
OBJECTIVE: The deficit syndrome is a subtype of schizophrenia characterized by primary and enduring negative features psychopathology. It appears to reflect distinct within the schizophrenia. Little known about familial or genetic aspects syndrome. purpose this study was determine whether versus nondeficit subtypes are correlated in sibling pairs affected with schizophrenia.METHOD: present based on Irish Study High-Density Schizophrenia Families. From earlier authors selected subset patients...
Three symptom groups, identified by factor analysis of schizophrenic symptoms, together with other clinical variables, were compared among 80 sibships (169 individuals) containing two or more members affected schizophrenia. The three factors, which labelled negative disorganization, and reality distortion, all showed a moderate but significant degree correlation between siblings. Age at onset was also significantly correlated. Such familial pattern heterogeneity suggests underlying common...
In Brief Study Design. Sixteen-week intervention for chronic patients with low back pain (LBP) 9-month follow-up. Primary randomization at 4 weeks into either supervised Swiss ball exercise or an advice group. Objective. To evaluate changes in disability and individuals LBP after combined treatment interventions, to whether self-report physical measures would best explain improvements Summary of Background Data. There is a need understand what the effectiveness clinically applicable...
Simulation environments (SE) are becoming important tools that can be leveraged to implement training protocols and educational resources. Electroencephalography (EEG) is used compare the effects of different types feedback in SE, but it challenging know which aspects EEG represent impact on neural processing. For this study, Minimum-Redundancy-Maximum-Relevance (MRMR) algorithm, MRMR conjunction with Mann-Whitney U statistical test were applied select most relevant features associated...
Aim: This pilot study investigated what alcohol prevention benefits could be achieved by a harm reduction focused school drug education intervention that addressed all use, both licit and illicit.Method: The population comprised cohort of 225 students in three secondary schools 93 matched control Victoria, Australia. A classroom programme, derived from evidence effective practice designed to reduce other harm, was provided the during years eight (13–14 year olds) nine (14–15 teachers trained...
Clinical features of familial schizophrenia were examined in 169 siblings from 80 families. Factor analysis symptoms produced a negative symptom factor (affective flattening and thought disorder), disorganization (inappropriate affect positive disorder) reality distortion (delusions hallucinations). The correlated positively with duration illness poor outcome. outcome early age at onset. only clear correlation between these factors affective was one the mania. There no significant gender...
Abstract Objective: This survey attempts to ascertain the attitude of general public towards mentally ill and former psychiatric patients in Ireland. Method: A random selection 155 adults were interviewed using Likert-type scales (29 items). Results: Factor analysis revealed four main dimensions: fear, lack sympathy, personal rejection perceived community rejection. Overall, respondents express a low level fear high sympathy ill. Lack correlated highly with older age group, lower educational...
<h3>Background</h3> Necrotising enterocolitis (NEC) is the commonest gastrointestinal emergency among premature infants, and accounts for significant morbidity mortality. Breast milk (BM) considered as best nutritional option to prevent NEC. Traditionally cow's milk-based fortifier added BM optimise growth of extremely thus potentially increasing risk More recently value replacing traditional with human breast [resulting in concept an exclusive (EHM) based diet] has been demonstrated reduce...
Due to their stabilizing role, the wrist extensor muscles demonstrate an earlier onset of performance fatigability and may impair movement accuracy more than flexors. However, minimal fatigue research has been conducted at wrist. Thus, purpose this study was examine how sustained isometric contractions extensors/flexors influence hand-tracking accuracy. While gripping handle a three-degrees-of-freedom manipulandum, 12 male participants tracked 2:3 Lissajous curve (± 32° flexion/extension; ±...