A5101835566- Melanoma and MAPK Pathways
- Cutaneous Melanoma Detection and Management
- Computational Drug Discovery Methods
- Advanced Fluorescence Microscopy Techniques
- Mathematical and Theoretical Epidemiology and Ecology Models
- Genetics and Neurodevelopmental Disorders
- Evolution and Genetic Dynamics
- Nonlinear Differential Equations Analysis
- Single-cell and spatial transcriptomics
- Mathematical Biology Tumor Growth
- Advanced Biosensing Techniques and Applications
- Cell Image Analysis Techniques
- Epilepsy research and treatment
- Genomics and Rare Diseases
- Monoclonal and Polyclonal Antibodies Research
- Ubiquitin and proteasome pathways
- Neurogenetic and Muscular Disorders Research
- vaccines and immunoinformatics approaches
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Prion Diseases and Protein Misfolding
- Neurogenesis and neuroplasticity mechanisms
- Neurological diseases and metabolism
- Stress Responses and Cortisol
- Molecular Biology Techniques and Applications
The Wistar Institute
2023-2025
Henan University of Economic and Law
2010-2021
Centre for Addiction and Mental Health
2018-2020
University of Toronto
2018
Beihang University
2013-2014
Institute of Molecular Biology, Academia Sinica
2004-2008
National Yang Ming Chiao Tung University
2008
China Medical University Hospital
2008
China Medical University
2008
Academia Sinica
2004
Pediatric refractory epilepsy is a broad phenotypic spectrum with great genetic heterogeneity. Next-generation sequencing (NGS) combined Sanger could help to understand the diversity and underlying disease mechanisms in pediatric epilepsy. Here, we report results from cohort of 172 patients aged 0–14 years. The pathogenicity identified variants was evaluated accordance American College Medical Genetics Genomics (ACMG) criteria. We 43 pathogenic or likely 40 (23.3%). Among these variants,...
Posttraumatic stress disorder (PTSD) can develop after exposure to severe psychological trauma, leaving patients with disabling anxiety, nightmares, and flashbacks. Current treatments are only partially effective, development of better is hampered by limited knowledge molecular mechanisms underlying PTSD. We have discovered that the glucocorticoid receptor (GR) FK506 binding protein 51 (FKBP51) form a complex elevated in PTSD compared unaffected control subjects, subjects exposed trauma...
We report a cellular barcoding strategy, SpaceBar, that enables simultaneous clone tracing and spatial transcriptomics profiling. Our approach uses library of 96 synthetic barcode sequences can be robustly detected by imaging based (seqFISH), delivered such each cell is labeled with combination barcodes. used these barcodes to label melanoma cells in tumor xenograft model profiled both identity gene expression situ . developed scoring metric quantifies how strongly driven intrinsic cues or...
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<div>Abstract<p>Resistance of <i>BRAF</i>-mutant melanomas to targeted therapy arises from the ability cells enter a persister state, evade treatment with relative dormancy, and repopulate tumor when reactivated. A better understanding temporal dynamics specific pathways leading into out state is needed identify strategies prevent failure. Using spatial transcriptomics in patient-derived xenograft models, we captured clonal lineage evolution during treatment. The...
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