A5014979782- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Bone Tissue Engineering Materials
- 3D Printing in Biomedical Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics and Neurodevelopmental Disorders
- Endoplasmic Reticulum Stress and Disease
- Microbial Inactivation Methods
- Immune Cell Function and Interaction
- Total Knee Arthroplasty Outcomes
- Osteoarthritis Treatment and Mechanisms
- Facial Trauma and Fracture Management
- Family Support in Illness
- Receptor Mechanisms and Signaling
- Viral Infections and Immunology Research
- Pharmacological Receptor Mechanisms and Effects
- Electrospun Nanofibers in Biomedical Applications
- RNA Research and Splicing
- Bipolar Disorder and Treatment
- RNA Interference and Gene Delivery
- Multiple Sclerosis Research Studies
- Adenosine and Purinergic Signaling
- Nuclear Receptors and Signaling
- Autophagy in Disease and Therapy
Zhejiang University
2024-2025
Centre for Addiction and Mental Health
2018-2024
Harbin Medical University
2019-2020
Second Affiliated Hospital of Harbin Medical University
2019-2020
University of Toronto
2019-2020
Harbin University
2020
Lunenfeld-Tanenbaum Research Institute
2014
Posttraumatic stress disorder (PTSD) can develop after exposure to severe psychological trauma, leaving patients with disabling anxiety, nightmares, and flashbacks. Current treatments are only partially effective, development of better is hampered by limited knowledge molecular mechanisms underlying PTSD. We have discovered that the glucocorticoid receptor (GR) FK506 binding protein 51 (FKBP51) form a complex elevated in PTSD compared unaffected control subjects, subjects exposed trauma...
Abstract Irreversible electroporation (IRE) is a novel local tumor ablation technique that can potentially stimulate immune responses. However, IRE alone cannot effectively activate the system or prevent distant metastases. Therefore, this study utilized biocompatibility of Chlorella vulgaris ( C. ) and polydopamine (PDA) adhesive properties to encapsulate PD‐1 inhibitor (PI). The PDA coating protects drug from degradation by stomach acid enhances its intestinal absorption. This carrier...
Platelet-rich fibrin (PRF), which functions as a growth factor carrier, has been extensively used to promote soft and hard tissue repair. However, whether decellularized PRF (DPRF) maintains its bioactive effects is unknown. Chitosan/gelatin(C/G) base scaffolds display appropriate biocompatibility mechanical properties, but they lack biological activity. Thus, the incorporation of DPRF into C/G scaffold can theoretically improve both bioactivity strength PRF. In this study, was prepared...
While most research and treatments for multiple sclerosis (MS) focus on autoimmune reactions causing demyelination, it is possible that neurodegeneration precedes the response. Hence, glutamate receptor antagonists preventing excitotoxicity showed promise in MS animal models, though blocking signaling prevents critical neuronal functions. This study reports discovery of a small molecule AMPA-mediated by targeting an allosteric binding site. A machine learning approach was used to screen...
Ischemic stroke is one of the leading causes long-term disability worldwide. It arises when blood flow to brain severely impaired, causing infarction. The current therapies for ischemic are tissue plasminogen activator and mechanical thrombectomy, which re-establishes circulation but offers no neuroprotective effects. Excitotoxicity, particularly through N-methyl-d-aspartate receptor (NMDAR), has been heavily implicated in pathophysiology infarction resulting from stroke. Here we...
Radiofrequency ablation (RFA) is a commonly used minimally invasive treatment for hepatocellular carcinoma (HCC). However, incomplete radiofrequency (iRFA) promotes tumor progression and metastasis. There an urgent need to develop innovative strategies enhance the efficacy of iRFA. The upregulation heat shock proteins (HSPs) activation protective autophagy in cells upon exposure sublethal thermotolerance, thereby promoting cell survival. Here, 3-methyladenine (3-MA) lonidamine (LND)...
There is strong evidence indicating neuroinflammation an important mediator in multiple sclerosis (MS), with astrogliosis playing a significant role this process. Surprisingly, astrocytes exert paradoxical roles during disease development, but the mechanisms remain unknown. Previously, we have reported that administering interfering peptide (GluA2-G-Gpep) which specifically disrupts GluA2-GAPDH interaction rescued neurological symptoms EAE mouse model of MS. In study, validated complex was...
Single-factor delivery is the most common characteristic of bone tissue engineering techniques.
Major depressive disorder (MDD) is associated with significant morbidity and mortality. Most antidepressant medications target the serotonin norepinephrine transporters, but a minority of patients do not respond to treatment novel therapeutic targets are needed. We previously identified protein complex composed α7 nicotinic acetylcholine receptor (nAChR) NMDA glutamate receptors (NMDARs), through which α7nAChR upregulates NMDAR function. Disruption α7nAChR-NMDAR an interfering peptide...
Fragile X syndrome (FXS) is an X-chromosome-linked dominant genetic disorder that causes a variable degree of cognitive dysfunction and developmental disability. Current treatment symptomatic no existing medications target the specific cause FXS. As with other X-linked disorders, FXS manifests differently in males females, including abnormalities dopamine system are also seen Fmr1-knockout (KO) mice. We investigated sex differences signaling Fmr1-KO mice response to L-stepholidine, D1...
Abstract Background Previous studies indicate a close association between the altered immune system and major depressive disorders. inhibition of neuroinflammation may represent an alternative mechanism to treat depression. Recently, anti-inflammatory activity ibrutinib has been reported, however, effect on allied depression its underlying not comprehensively studied. Therefore, we aimed elucidate potential anti-depressive role against induced as well synaptic defects. Methods Adult C57BL/6J...