A5016163505- Extracellular vesicles in disease
- Cerebrovascular and Carotid Artery Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic aneurysm repair treatments
- Atherosclerosis and Cardiovascular Diseases
- Mechanical Circulatory Support Devices
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Cardiac Arrest and Resuscitation
- Lipoproteins and Cardiovascular Health
- MicroRNA in disease regulation
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Cell Adhesion Molecules Research
- Diversity and Career in Medicine
- Venous Thromboembolism Diagnosis and Management
- Osteoarthritis Treatment and Mechanisms
- Dental Education, Practice, Research
- Tendon Structure and Treatment
- Proteoglycans and glycosaminoglycans research
- Multiple Sclerosis Research Studies
- Infective Endocarditis Diagnosis and Management
- Cytomegalovirus and herpesvirus research
- Tracheal and airway disorders
- Aortic Disease and Treatment Approaches
University of Toronto
2014-2024
Toronto General Hospital
2015-2024
University Health Network
2015-2024
Second Military Medical University
2024
Amrita Vishwa Vidyapeetham
2024
Toronto General Hospital Research Institute
2023
Health Net
2022
Sunnybrook Health Science Centre
2020
Health Sciences Centre
2020
Roche (Canada)
2020
Abstract Background Type 2 diabetes (T2D) is associated with coronary microvascular dysfunction, which thought to contribute compromised diastolic function, ultimately culminating in heart failure preserved ejection fraction (HFpEF). The molecular mechanisms remain incompletely understood, and no early diagnostics are available. We sought gain insight into biomarkers potential of dysfunction obese mouse ( db/db ) lean rat (Goto-Kakizaki) pre-clinical models T2D-associated dysfunction....
Extracellular vesicles (EVs) contain bioactive cargo including miRNAs and proteins that are released by cells during cell-cell communication. Endothelial (ECs) form the innermost lining of all blood vessels, interfacing with in circulation vascular wall. It is unknown whether ECs release EVs capable governing recipient within these 2 separate compartments. Given their boundary location, we propose use bidirectional distinct EV quiescent (healthy) activated (atheroprone) states to communicate vessel
This study examined actin regulation of fibroblast matrix genes in dedifferentiated chondrocytes. We demonstrated that chondrocytes exhibit increased polymerization, nuclear localization myocardin related transcription factor (MRTF), type I collagen (col1) and tenascin C (Tnc) gene expression, decreased Sox9 expression. Induction depolymerization by latrunculin treatment or cell rounding, reduced MRTF localization, repressed col1 Tnc expression Treatment passaged with inhibitor but did not...
Background Statins are commonly used for the prevention of cardiovascular events; however, statins underutilized in patients with noncoronary atherosclerosis. We sought to establish rates statin use carotid artery disease and examine association between therapy outcomes after revascularization. Methods Results In this population-level retrospective cohort study, we identified all individuals aged ≥66 years who underwent endarterectomy or stenting Ontario, Canada (2002-2014). The primary...
Atypical chemokine receptor-1 (ACKR1), previously known as the Duffy antigen receptor for chemokines, is a widely conserved cell surface protein that expressed on erythrocytes and endothelium of post-capillary venules. In addition to being parasite causing malaria, ACKR1 has been postulated regulate innate immunity by displaying trafficking chemokines. Intriguingly, common mutation in its promoter leads loss erythrocyte but leaves endothelial expression unaffected. Study limited rapid...
The objective of this study is to review and analyze readmission data for patients who received a continuous flow left ventricular assist device (LVAD).A retrospective 88 implanted with continuous-flow LVAD between June 2006 2014 was performed. Reason readmission, frequency, length stay, procedures performed during each were recorded. All followed in our clinic all readmissions reported program.Sixty-seven (76%) discharged following their hospitalization implant. In these patients,...
The literature examining clinical outcomes and readmissions during extended (> 1 yr) left ventricular assist device (LVAD) support is scarce, particularly in the era of continuous-flow LVADs.We completed a retrospective cohort study on consecutive LVAD patients from June 2006 to March 2015, focusing those who received more than year total time. Demographic characteristics, were analyzed using standard statistical methods. All categorized as per Interagency Registry for Mechanically Assisted...
Carotid atherosclerosis is orchestrated by cell-cell communication that drives progression along a clinical continuum (asymptomatic to symptomatic). Extracellular vesicles (EVs) are cell-derived nanoparticles representing new paradigm in cellular communication. Little known about their biological cargo, origin/destination, and functional roles human atherosclerotic plaque.
Abstract Rationale: Extracellular vesicles (EVs) contain bioactive cargo including microRNAs (miRNAs) and proteins that are released by cells as a form of cell-cell communication. Endothelial (ECs) the innermost lining all blood vessels thereby interface with in circulation well residing vascular wall. It is unknown whether ECs have capacity to release EVs capable governing recipient within two separate compartments, how this affected endothelial activation commonly seen atheroprone regions....
We developed novel artificial flowers that dispense and receive powdered food dyes as pollen analogues while their nectar is replenished by capillary action. Dye receipt, which can be measured colourimetrically, a direct surrogate for receipt or female reproductive success, but also serve to compare donation (male success) from with different colours of dye. By allowing captive bumble bee colonies visit large arrays such flowers, we investigated whether total dye depended on the sugar...
Within a matter of 48 hours, the promotion article entitled "Prevalence unprofessional social media content among young vascular surgeons," aptly demonstrated power and dangers unconscious bias as it spread across Twitter with #MedBikini tag. In response, surgeons from around world have come together in call to action address highlight misogynistic, racist, oppressive issues facing today. We, female surgery trainees, would like make our own action. The publication this (now appropriately...
An 85-year-old man presented with an acute asymptomatic lateral neck mass in the context of deep tissue massages during past year. He was referred to vascular surgery after ultrasound examination revealed a thrombus external jugular vein. His medical history and comorbidities were noncontributory. A multidisciplinary team surgeons hematologists did not recommend any anticoagulation, given that patient have risk factors for thrombosis as well normal D-dimer levels. The maintained on his...
<h3>Background:</h3> Endovascular aneurysm repair (EVAR) is associated with decreased perioperative morbidity and mortaliy in comparison open repair, thus octagenarians are traditionally offered EVAR given their age medical comorbidities. The aim of this study was to investigate outcomes predictors complications octogenarians. <h3>Methods:</h3> We conducted a retrospective chart review consecutive patients aged 80 years older who received an between August 2010 January 2017 at single centre...
Studies have demonstrated gender differences in adverse events after cardiac surgery, with men experiencing more favorable outcomes. The scarce gender-focused literature the left ventricular assist device (LVAD) population has failed to find consistent differences. It also been suggested that women experience longer transplant wait times due higher PRA values.A retrospective chart review was conducted of 28 and 75 who received an LVAD from 2006-2015. Chi squares, T tests, nonparametric...
in China.His MS and PhD areas of expertise are physiology, his postdoctoral research focused on pathophysiology.This work is a continuation the previous study cardiac dysfunction following ZBTB20 global knockout.His main area pathogenesis cardiovascular diseases.The biggest realization he had this that no matter how many difficulties one encounters, as long you persist, will definitely achieve success.
To study the prescribing patterns and usage of antimicrobials in Neonatal Intensive Care Units (NICU) Trinidad & Tobago.A 3-month prospective observational was conducted at three NICUs major public hospitals. Data included prescribed, route administration, culture sensitivity reports, leukocyte count, length stay outcome patients.353 patients were studied, 57.5% males. Mean birth weight 2.96 ± 0.94 (Standard Deviation) kg. Admission diagnoses meconium stained liquor, preterm, respiratory...
Aim: The ETS transcription factor ERG has been identified as a principal regulator of endothelial function through its ability to repress inflammation in cells (ECs), and loss induces mesenchymal transition (EndMT) fibrotic disease. To investigate atherosclerosis, we employed an EC-specific Erg knockout ( EC - KO ) PCSK9-overexpression apoE-deficient murine atherosclerosis models. Methods: Atherosclerosis was induced 10-week-old mice or wild-type counterparts that had Cre-inducible lineage...