A5080797202- Autophagy in Disease and Therapy
- Cellular transport and secretion
- Neuroinflammation and Neurodegeneration Mechanisms
- Calcium signaling and nucleotide metabolism
- Alzheimer's disease research and treatments
- interferon and immune responses
- Toxic Organic Pollutants Impact
- Neuroscience and Neuropharmacology Research
- Metabolomics and Mass Spectrometry Studies
- Neurotransmitter Receptor Influence on Behavior
- Psychedelics and Drug Studies
- Circadian rhythm and melatonin
- Immune Response and Inflammation
- Fatty Acid Research and Health
- Adipose Tissue and Metabolism
- Tryptophan and brain disorders
- Environmental Toxicology and Ecotoxicology
Nanjing Medical University
2021-2024
Abstract Background Autophagic defects are involved in Methamphetamine (Meth)-induced neurotoxicity. Syntaxin 17 (Stx17), a member of the SNARE protein family, participating several stages autophagy, including autophagosome-late endosome/lysosome fusion. However, role Stx17 and potential mechanisms autophagic induced by Meth remain poorly understood. Methods To address mechanism Meth-induced cognitive impairment, adenovirus (AV) adeno-associated virus (AAV) were injected into hippocampus for...
Severe neurological inflammation is one of the main symptoms methamphetamine (meth)-induced brain injury. Studies have demonstrated that meth exposure facilitates neuroinflammation via Pellino E3 ubiquitin protein ligase 1 (Peli1)-mediated signaling. However, involved mechanisms remain incompletely understood. Herein, we used Peli1–/– mice and Peli1-knockdown microglial BV2 cells to decipher roles Peli1 downstream signaling in meth-induced neuroinflammation. After administration for seven...
Methamphetamine (Meth), a central nervous system (CNS) stimulant with strong neurotoxicity, causes progressive cognitive impairment characterized neurodegenerative changes. However, the mechanism underlying Meth-induced pathological changes remains poorly understood. In current study, Meth elicited striking accumulation of proteins hyperphosphorylated tau (p-tau) and amyloid beta (Aβ) in primary hippocampal neurons, while activation autophagy dramatically ameliorated high levels these...
Polyhalogenated carbazoles (PHCZs) are emerging environmental pollutants, yet limited information is available on their embryotoxicity and neurotoxicity. Therefore, the current work was performed to investigate adverse effects of 3,6-dibromocarbazole (3,6-DBCZ), a typical PHCZs homolog, early life stages zebrafish larvae. It revealed that 96-hour post-fertilization (hpf) median lethal concentration (LC
This Carbon black nanoparticles (CBNPs), a common and important manufacturing material, have been proven to exert adverse effects on brain function; however, the underlying neurotoxicity remains poorly understood.To unravel deteriorating effect of CBNPs brain, chronic long-term carbon exposure mouse model (0 , 0.15 mg/ml, 0.5 1.5 mg/ml groups) was established via nasal injection for 3 months.Intriguingly, evidence directly showed penetration in as electron microscopic data an obvious...
Methamphetamine (METH) abuse disrupts the homeostasis of neurotransmitter (NT) metabolism, contributing to a wide range neurological and psychological disorders. However, specific effects METH on NT particularly for tryptophan (TRP) tyrosine (TYR) metabolic pathways, remain poorly understood. In this study, serum samples from 78 abusers 79 healthy controls were analyzed using Ultra-High-Performance Liquid Chromatography with Tandem Mass Spectrometry (UHPLC-MS/MS). A total 41 substances,...