A5100380598- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Aquaculture disease management and microbiota
- Vibrio bacteria research studies
- Nanoplatforms for cancer theranostics
- Bacteriophages and microbial interactions
- Cassava research and cyanide
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Plant Pathogens and Fungal Diseases
- Brain Metastases and Treatment
- Colorectal Cancer Treatments and Studies
- Healthcare and Venom Research
- Bacterial biofilms and quorum sensing
- Electrospun Nanofibers in Biomedical Applications
- Bacterial Genetics and Biotechnology
- Venomous Animal Envenomation and Studies
- Ferroptosis and cancer prognosis
- Antimicrobial Peptides and Activities
- High-Temperature Coating Behaviors
- Magnesium Alloys: Properties and Applications
- Peptidase Inhibition and Analysis
- Plant-Microbe Interactions and Immunity
- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
Hainan University
2015-2025
Affiliated Hospital of Southwest Medical University
2022-2025
Yunnan Agricultural University
2024-2025
Merck & Co., Inc., Rahway, NJ, USA (United States)
2024-2025
Southwest Medical University
2022-2025
Liaoning Cancer Hospital & Institute
2023-2024
China Medical University
2023-2024
Shenyang Pharmaceutical University
2023-2024
Shanghai Jiao Tong University
2021-2024
Chengdu Center for Disease Control and Prevention
2016-2023
<p>The sustainability of life on Earth is under increasing threat due to human-induced climate change. This perilous change in the Earth's caused by increases carbon dioxide and other greenhouse gases atmosphere, primarily emissions associated with burning fossil fuels. Over next two three decades, effects change, such as heatwaves, wildfires, droughts, storms, floods, are expected worsen, posing greater risks human health global stability. These trends call for implementation...
Diabetes is a major metabolic disease that requires long-term pharmacotherapy. Bioactive peptides have unique advantages such as higher potency, selectivity, and safety over small molecules achieved great success in the treatment of diabetes. We previously isolated dipeptidyl peptidase-IV (DPP-IV) inhibitory peptide VPLVM with IC50 = 99.68 μM from protein hydrolysates broccoli stems leaves. Here, we evaluated interaction DPP-IV, transport, stability, vivo hypoglycemic effects VPLVM....
Understanding the corrosion mechanism of austenitic stainless steels (ASS) exposed to supercritical carbon dioxide (SC-CO2) is particular crucial for designing high performance steels. In this work, resistance ASS significantly strengthened with increase Al content, alongside improvement anti-carburizing capability. This enhancement due formation Al/Si-rich inner oxide layer, which can effectively mitigate oxidation and intergranular corrosion. On other hand, layer Al2O3 hinder intrusion,...
The trans-translation system, mediated by transfer-messenger RNA (tmRNA, encoded the ssrA gene) and its partner protein SmpB, helps to release ribosomes stalled on defective mRNA targets incomplete products for hydrolysis. Knocking out smpB genes in various pathogens leads different phenotypic changes, indicating that they have both cooperative independent functionalities. This study aimed clarify functional relationships between tmRNA SmpB Aeromonas veronii, a pathogen poses threats...
Integrated imaging techniques offer enhanced medical insights into the central nervous system by combining different modalities. In glioma diagnosis, challenge often lies in delivering contrast agents effectively across blood-brain barrier. We present an integrated multimodal biohybrid, GV@pCY5, which enables barrier penetrating as well fluorescence and ultrasound (FL/US) capabilities. This biohybrid is created decorating a far-red-fluorescent cyanine dye (CY5) onto polyethyleneimine...
Abstract Ventricular arrhythmias associated with cardiac adrenergic stress and hypertrophy pose a significant clinical challenge. We explored ventricular anti‐arrhythmic effects of P21‐activated kinase 2 (Pak2), comparing in vivo ex cardiomyocyte‐specific Pak2 knockout (Pak2 cko ) or overexpression ctg murine models, under conditions acute stress, following chronic transverse aortic constriction (TAC). was downregulated 5 weeks the latter TAC Cellular physiological, optical action potential...
We report the total synthesis of enlicitide decanoate, an orally bioavailable inhibitor proprotein convertase subtilisin/kexin type 9 that is being developed for treatment atherosclerotic cardiovascular disease. It a highly complex macrocyclic peptide with significant number nonpeptide structural elements presents daunting synthetic chemistry challenge. describe development convergent, efficient, and robust manufacturing process enables large-scale production enlicitide.
For studying the strata behavior due to multi-slicing top coal caving longwall mining along-the-strike direction in steeply dipping extra thick seams, shield support pressures of upper and lower slices panel 37220 Dongxia Coal Mine were monitored using KJ513 dynamic monitoring system. The set up rooms adopted "horizontal line-arc segment-inclined line" form used different types supports. results show that pressure slice 37220-1 changed slightly along strike direction, while dip it exhibited...
Objective. Ageing is one of the risk factors associated with cardiovascular diseases including cardiac arrhythmias and heart failure. Ageing-related dysfunction involves a complicated pathophysiological progress. Abnormal membrane voltage Ca2+ dynamics in aged cardiomyocytes contribute to ageing-related arrhythmias. However, its underlying mechanisms have not been well clarified. Methods. Young old rats or mice were included this study. Cardiac electrophysiological properties functions...
Abstract Drug delivery systems (DDSs) capable of sequential multistage drug release are urgently needed for antibacterial applications. Herein, a molecular switch‐integrated, photo‐responsive nanoplatform is reported based on hollow mesoporous silica nanospheres (HMSN) loaded with silver nanoparticles (Ag NPs), vancomycin (Van), and hemin (HAVH) bacteria elimination abscess therapy. Upon near‐infrared (NIR) light irradiation, the switch, hemin, can effuse from mesopores HMSN, triggering...
Electrospun scaffolds with excellent mechanical properties, high specific surface area and a commendable porous network are widely used in tissue engineering. Improving the hydrophilicity cell adhesion of hydrophobic substrates is key point to enhance effectiveness electrospun scaffolds. In this study, polycaprolactone (PCL) fibrous membranes appropriate diameter were selected coated by mussel-inspired poly norepinephrine (pNE). And catecholamine functioning as hormone neurotransmitter human...
Acrylamide content in food market China was determined with the goal to evaluate related health concern. In this survey, products of rice, potato corn, wheat as well dried fruit slices and instant foods were analysed. All these types thermal-processed carbohydrate-rich frequently consumed China. They purchased from markets Zhejiang province analysed using a liquid chromatography tandem/mass spectrometry method. detected 94.3% 105 investigated samples, ranging 10 3649 μg/kg an average value...
Previous observational studies suggested inconsistent insights on the associations between meat intake and risk of digestive tract cancers (DCTs). The causal effect DCTs is unclear. Two-sample Mendelian randomization (MR) was performed based genome-wide association (GWAS) summary data from UK Biobank FinnGen to evaluate [processed meat, red (pork, beef, lamb), white (poultry)] (esophageal, stomach, liver, biliary tract, pancreatic, colorectal cancers). effects were estimated using a primary...
Paclitaxel is a microtubule-targeting agent widely used for the treatment of many solid tumors. However, patients show variable sensitivity to this drug, and effective diagnostic tests predicting drug remain be investigated. Herein, we that expression end-binding protein 1 (EB1), regulator microtubule dynamics involved in multiple cellular activities, breast tumor tissues correlates with pathological response tumors paclitaxel-based chemotherapy. In vitro cell proliferation assays reveal EB1...