A5102489192- Vasculitis and related conditions
- Renal Diseases and Glomerulopathies
- Inflammasome and immune disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Asthma and respiratory diseases
- T-cell and B-cell Immunology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cell Adhesion Molecules Research
- Smart Grid Energy Management
- Microgrid Control and Optimization
- Antifungal resistance and susceptibility
- Otitis Media and Relapsing Polychondritis
- Immune Cell Function and Interaction
- Pneumocystis jirovecii pneumonia detection and treatment
- IL-33, ST2, and ILC Pathways
- Pleural and Pulmonary Diseases
- Complement system in diseases
- Viral Infections and Vectors
- Neural Networks and Applications
- Phase-change materials and chalcogenides
- Inflammation biomarkers and pathways
- Advanced Surface Polishing Techniques
- Maritime Ports and Logistics
- Amoebic Infections and Treatments
Xiangya Hospital Central South University
2020-2024
National Clinical Research Center for Digestive Diseases
2023-2024
Central South University
2020-2024
Jimei University
2024
Hunan University of Technology
2024
China University of Mining and Technology
2023
Abstract Background The pattern recognition receptor Dectin-1 was initially discovered to play a pivotal role in mediating pulmonary antifungal immunity and promoting neutrophil-driven inflammation. Recent studies have revealed that is overexpressed asthma, but the specific mechanism remains elusive. Additionally, has been implicated pyroptosis, hallmark of severe asthma airway Nevertheless, involvement non-classical pyroptosis signal caspase-11/4 its upstream regulatory mechanisms not...
Inhalation represents a significant route of cadmium (Cd) exposure, which is associated with an elevated risk lung diseases. This research study aims to evaluate the impact repeated low-dose inhalation on exacerbating airway inflammation induced by ovalbumin (OVA) in asthma-afflicted mice. Mice were grouped into four categories: control (Ctrl), OVA, chloride (CdCl2), and OVA + (OVA CdCl2). group displayed increased mucus secretion peribronchial characterized eosinophil cell infiltration,...
Mucosal immune-associated γδ T cells have been implicated in IgA nephropathy (IgAN). However, the involvement of Vδ1 cells, major subtype, renal damage and mechanism underlying their migration from peripheral blood to kidney IgAN remain unclear.Clinical data patients healthy controls (HC) were analyzed. Phenotypes chemokine receptors cell compared between HC. Immunohistochemistry immunofluorescence performed assess infiltration subsets expression tissues. In vitro, C5a was used stimulate...
Abstract Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is an autoimmune disease that involves inflammation of blood vessels. There increasing evidence platelets play a crucial role not only in hemostasis but also and innate immunity. In this study, we explored the relationship between platelet count, clinical characteristics, prognosis patients with AAV. We divided 187 into two groups based on their count. Clinicopathological data prognostic information were retrospectively...
For batch time-varying processeswith non-repetitive disturbances, a cross-coupling indirect iterative learning control (CC-iILC) is proposed. The set trajectory of the system on single axis accurately tracked by an strategy with PI controller for its time direction and closed-loop feedback direction. Under asymptotically stable condition two-dimensional (2D) dynamic model, optimal law obtained optimizing H-infinity function. To avoid contour error during coupling, technique used to...
With the continuous prosperity of maritime transportation on a global scale and resulting escalation in port trade volume, tugboats assume pivotal role as essential auxiliary tools influencing ingress egress vessels into out ports. As result, optimization tug scheduling becomes paramount importance, it contributes to heightened efficiency ship movements, cost savings operations, promotion sustainable development within realm transportation. However, majority current tugboat models tend focus...
Abstract Background Monocytes are involved in tumor growth and metastasis, but the distribution of monocyte phenotypes their role development malignant pleural effusion (MPE) remains unknown. Methods A total 94 MPE patients (76 diagnosed with adenocarcinoma lung cancer 18 squamous cell cancer) 102 volunteers for health examination Xiangya Hospital from December 2016 to 2019 were included study. Results The subtypes identified by expression CD14 CD16 analyzed flow cytometry. proportion ++ +...
Pleural effusion is a common clinical condition caused by several respiratory diseases, including tuberculosis and malignancy. However, rapid accurate diagnoses of tuberculous pleural (TPE) malignant (MPE) remain challenging. Although monocytes have been confirmed as an important immune cell in malignancy, little known about the role subpopulations diagnosis effusion.Pleural samples peripheral blood were collected from 40 TPE patients, MPE 24 transudate respectively. Chemokines (CCL2, CCL7,...
Background Monocytes are involved in the pathogenesis of ANCA-associated vasculitis (AAV). Monocyte/macrophages dominant infiltrating cells glomeruli patients with myeloperoxidase-AAV (MPO-AAV). However, how human monocyte subsets extravasate to kidney MPO-AAV renal damage is unclear. Methods 30 and 22 healthy controls were enrolled this study. Monocyte monocyte-related chemokines blood kidneys detected. The chemoattractant activity CX3CL1-CX3CR1 axis on CD16 + monocytes was observed. effect...
Intelligent prediction of key output variables that are difficult to measure online in complex systems has important research significance. In this paper, by using the least absolute shrinkage and selection operator (LASSO) algorithm analyze principal elements input variables, a temporal convolutional network fused with long short-term memory (TCN-LSTM) self-attention mechanism (SAM) is designed realize dynamic modeling multivariate feature sequences. For processes multiple each variable...
Abstract Background Effector memory T cells are pivotal effectors of adaptive immunity with enhanced migration characteristics and involved in the pathogenesis ANCA-associated vasculitis (AAV). The diversity effector chemokine receptor expression has been well studied proteinase 3 (PR3)-AAV. However, few studies have conducted myeloperoxidase (MPO)-AAV. Here, we characterized on from patients active MPO-AAV. Methods Clinical data newly diagnosed MPO-AAV healthy subjects were collected...
In the context of expanding diversity energy demands, an increasing number heterogeneous Multi-energy Microgrids (MEMGs) are engaging in collaborative framework Multi-microgrid System (MEMMG). However, following this trend, existing centralized Integrated Energy Management (IEMS) control strategy is unreliable for future systems, characterized by more complex optimization and a flexible system structure. This paper introduces hierarchical Multi-agent Deep Reinforcement Learning (HMADRL)...
Allergic bronchopulmonary aspergillosis/mycosis (ABPA/M) is a complex non-infectious pulmonary benign disease characterized by an immune response against aspergillus/fungus. Carcinoembryonic antigen (CEA), typically recognized as tumor marker, also elevated in certain diseases. Few studies on ABPA/M cases presenting with serum CEA levels have been reported. A cohort of 115 patients diagnosed were divided into two groups (CEA normal and elevated). The characteristics terms its demographic...
For complex multi-input/output systems, this paper proposes a parallel GRU-LSTM neural network prediction strategy with self-attention mechanism. In order to eliminate the influence between variables, multidimensional input time series in system is normalized. The convolution layer used extract initial feature from sampled data. One branch uses LSTM and memorize long-term features. other GRU improve ability of short-term sequence memory. mechanism integrated realize strengthening memory...
Journal of the American Society Nephrology 31(10S):p 546, October 2020. | DOI: 10.1681/ASN.20203110S1546b
Abstract: Myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) associated vasculitis is an autoimmune disease usually with severe multiple dysfunction syndrome, especially prominent acute renal failure. A 65-year-old woman was admitted progressive dyspnoea for six months and fever, sputum blood, pain of the lower extremities intermittent claudication two days, indicating organ involvement (respiratory system, blood vessels). The relatively mild, presenting microscopic haematuria....