The overall control of the quality botanical drugs starts from raw material, continues through preparation drug substance and culminates with product. Chromatographic spectroscopic fingerprinting has been widely used as a tool for herbal/botanical medicines. However, discussions are still on-going on whether single technique provides adequate information to drugs. In this study, high performance liquid chromatography (HPLC), ultra (UPLC), capillary electrophoresis (CE) near infrared...

Panax notoginseng is a highly valued medicine and functional food, whose quality considered to be influenced by the size, botanical parts, growth environments. In this study, HPLC method integrating fingerprinting determination of multiconstituents single reference standard was established adopted investigate chemical profiles active constituent contents 215 samples with different sizes, from parts geographical regions. Chemical differences among main root, branch rotten root were not...

Collecting hyperspectral data of licorice from different origins, processing the in three methods, and using multiple classifiers for origin classification, results showed that U-Net method could effectively improve accuracy classification.

The growing use of herbal dietary supplements (HDS) in the United States provides compelling evidence for risk herbal-induced liver injury (HILI). Information on HDS products was retrieved from MedlinePlus U.S. National Library Medicine and monograph European Medicines Agency. hepatotoxic potential ascertained by considering published case reports. Other relevant data were collected governmental documents, public databases, web sources, literature. We information 296 unique products....

Red ginseng is widely used in food and pharmaceuticals due to its significant nutritional value. However, during the processing storage of red ginseng, it susceptible grow mold produce mycotoxins, generating security issues. This study proposes a novel approach using hyperspectral imaging technology 1D-convolutional neural network-residual-bidirectional-long short-term memory attention mechanism (1DCNN-ResBiLSTM-Attention) for pixel-level mycotoxin recognition ginseng. The “Red...

There has been an increasing demand for rapid and sensitive techniques the detection of heavy metal ions that are harmful to human body in traditional Chinese medicine (TCM). However, complex chemical composition TCM makes quantitative difficult. In this study, magnetic Fe3O4@SiO2@AuNPs nanoparticles combined with a probe molecule DMcT were used specific enrichment Hg2+ system licorice. The core Fe3O4 was bonded SiO2 increase its stability. A layer AuNPs deposited produce “core–shell” Raman...

Abstract Several studies provide insight into the landscape of breast cancer genomics with genomic characterization tumors offering exceptional opportunities in defining therapies tailored to patient’s specific need. However, translating data personalized treatment regimens has been hampered partly due uncertainties deviating from guideline based clinical protocols. Here we report a approach predict favorable outcome responses thus enabling medicine selection regimens. The were divided...

An effective approach for assessing a drug’s potential to induce autoimmune diseases (ADs) is needed in drug development. Here, we aim develop workflow examine the association between structural alerts and drugs-induced ADs improve toxicological prescreening tools. Considering reactive metabolite (RM) formation as well-documented mechanism drug-induced ADs, investigated whether presence of certain RM-related was predictive risk AD. We constructed database containing 171 alerts, generated...

We aimed to analyze and evaluate the safety signals of ribavirin-interferon combination through data mining US Food Drug Administration Adverse Event Reporting System (FAERS), so as provide reference for rationale use these agents in management relevant toxicities emerging patients with novel coronavirus pneumonia (COVID-19).Reports FAERS from 1 January 2004 8 March 2020 were analyzed. The proportion report ratio (PRR), reporting odds (ROR), Bayesian confidence interval progressive neural...

An intelligently and globally extracting feature information method, different from a multi-wavelength fusion is used in HPLC-DAD chromatography. It combined with chemometrics suitable for quality control of traditional Chinese medicines.

Achyranthes bidentata is always salt-processed before being prescribed for treating osteoarthritis. Yet the salt-processing parameters have not been optimized, and specific bioactive constituents responsible osteoarthritis effect of A. fully elucidated. In this study, a Box–Behnken experimental design was chosen optimization bidentata, including stir-frying time, concentration brine, soak time. Meanwhile, HPLC–Q-TOF-MS utilized to analyze chemical profiles various batches raw bidentata. The...

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Traditional Chinese Medicine (TCM) formulations often contain a complex mixture of compounds, making it challenging to evaluate their quality. Buzhong Yiqi Oral Liquid (BYOL), well-known TCM formulation, has been used treat gastrointestinal diseases and fatigue for long time. However, the effective substances its therapeutic effects remain unclear. This study aimed establish novel quality control approach BYOL using multidimensional feature network identify markers (Q-markers). The...

A set of central composite design experiments were designed by using four factors which ethanol amount, concentration, refrigeration temperature and time. The relation between these with the target variables retention rate schizandrol A, soluble solids content, removal fructose glucose analyzed Bayesian networks, amount concentration found as critical process parameters. Then a network model was built 2 inputs 4 outputs back propagation artificial neural networks optimized genetic...

It is the objective of this study to develop dynamic predictive model for extraction process red Ginseng using NIR spectroscopy. spectroscopy was collected online and PLSR models were developed total quantity ginsenosides. The performance prediction achieved R, RMSEC, RMSEP 0.996 09, 0.018 9, 0.016 8, respectively. A first order mass transfer combined with quality indicator predict trajectory based upon initial 3 or 4 data points. results showed good agreement actual measurements indicating...

It is the objective of this study to optimize extraction process red ginseng minimize unit cost extracting effective ingredients. The relation between target variables total quantity ginsenosides and first time, solution amount, second extract amount were studied with Box-Behnken experimental design method. At same we also considered energy usage. function was set as (total or its purity) for multi-objective optimization process. As a result, optimal parameters found time (108.7 min), folds...

The synergetic lexical model provides a unique framework for exploration of the interrelationships between properties languages. Previous studies concerning several this have yielded many successful fittings results, but very few investigated synonymy, major property model. present study uses 825 Chinese and 848 English tokens retrieved from corpora, dictionaries, thesaurus to conduct contrastive on interrelations four model: word length, frequency, polysemy, synonymy. both languages...