A5100748061- PARP inhibition in cancer therapy
- Cardiac electrophysiology and arrhythmias
- Genetic factors in colorectal cancer
- Autophagy in Disease and Therapy
- Colorectal Cancer Screening and Detection
- Cardiac Arrhythmias and Treatments
- Cancer-related gene regulation
- Plant Stress Responses and Tolerance
- PI3K/AKT/mTOR signaling in cancer
- Pediatric health and respiratory diseases
- Meat and Animal Product Quality
- Evolution and Genetic Dynamics
- Signaling Pathways in Disease
- Esophageal Cancer Research and Treatment
- Atrial Fibrillation Management and Outcomes
- Glycosylation and Glycoproteins Research
- Mathematical and Theoretical Epidemiology and Ecology Models
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Cardiac pacing and defibrillation studies
- Helicobacter pylori-related gastroenterology studies
- Plant responses to water stress
- Kidney Stones and Urolithiasis Treatments
- Pancreatic function and diabetes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
State Key Laboratory of Respiratory Disease
2024
Guangzhou Medical University
2005-2024
Zhejiang University
2017-2022
Shandong University
2022
Anhui Agricultural University
2021-2022
Tongren Hospital
2021-2022
Shanghai Jiao Tong University
2022
Tianjin Academy of Agricultural Sciences
2022
Sun Yat-sen University
2014-2021
South China University of Technology
2019-2021
Summary We evaluated factors limiting lactating Mongolian gerbils (Meriones unguiculatus) at three temperatures (10°C, 21°C and 30°C). Energy intake daily energy expenditure (DEE) increased with decreased ambient temperature. At peak lactation (day 14 of lactation), from 148.7 ± 5.7 kJ.day-1 30°C to 213.1 8.2 248.7 12.3 10°C. DEE 105.1 4.0 134.7 5.6 179.5 8.4kJ.day-1 10°C on days 14-16 lactation. With nearly identical mean litter sizes exported 32.0 less as milk lactation, than those...
Background and Purpose Activation of PKC‐ζ is closely linked to the pathogenesis cardiac hypertrophy. can be activated by certain lipid metabolites such as phosphatidylinositol (3,4,5)‐trisphosphate ceramide. However, its endogenous negative regulators are not well defined. Here, role sirtuin1‐PKC‐ζ signalling axis underlying molecular mechanisms were investigated in Experimental Approach Cellular hypertrophy cultures myocytes, from neonatal Sprague‐Dawley rats, was monitored measuring cell...
Environmental drought stress threatens rice production. Previous studies have reported that related NAC (NAM, ATAF1/2, and CUC) transcription factors play an important role in stress. Herein, we identified characterized OsNAC092, encoding factor is highly expressed induced during tolerance. OsNAC092 knockout lines created using the clustered regularly interspaced palindromic repeats (CRISPR)-associated protein 9 (Cas9) system exhibited increased resistance rice. RNA sequencing showed of...
Long-term recurrence (LR) is a tendency that re-occurs within 3 months after catheter ablation for atrial fibrillation (AF). Whether very early (VER) 7 days of post prognostic factor LR or not unclear. For this reason, present study sought to examine the relationship between VER and LR. In prospective analysis 378 consecutive patients underwent an initial paroxysmal persistent AF. The association was analyzed by univariate multivariate Cox regression, as well time-dependent receiver operator...
The bark of Uncaria rhynchophylla has been traditionally used to treat convulsion, bleeding, hypertension, auto-immune conditions, cancer, and other diseases. main focus this research is done for the purpose exploring antitumor activity mechanism action (MOA) hirsutine isolated from U. rhynchophylla.Jurkat clone E6-1 cells were treated using 10, 25 50 μM 48 h. Inhibition cell proliferation due treatment was evaluated by CCK8 assay. Flow cytometry applied ascertain Jurkat cycle progression...
Poly(ADP-ribosyl)ation (PARylation) and SUMO modification (SUMOylation) are novel post-translational modifications (PTMs) mainly induced by PARP1 SUMO1. Growing evidence has revealed that C/EBPβ plays multiple roles in biological processes participates cardiovascular diseases. However, the cross-talk between PARylation SUMOylation during diseases is unknown. This study aims to investigate effects of PTMs on cardiac hypertrophy its underlying mechanism. Abdominal aortic constriction (AAC)...
Bio-implants are widely used in clinic for repair defected bone, however, clinical trace always found that the poor osseointegration often results bone failure. In this study, we investigated whether simvastatin loaded onto sulfonated PEEK (SP) surfaces enhances formation effect of SP samples. Our showed loading could significantly enhance type H vessels, which pivotal and specific vessels showing strong association with formation. Further, osteogenesis was to be strongly correlated release....
Hemodialysis is the main approach for renal replacement therapy in patients with end-stage disease (ESRD) China. The timing of dialysis initiation one key factors influencing patient survival and prognosis. Over past decade, relationship between mortality has remained unclear ESRD China.Patients who commenced maintenance hemodialysis from 2009 to 2014 24 centers Mainland China were enrolled study (n = 1,674). Patients divided into 2 groups based on year they started (patients 2011, 2012...
The aim of this case-control study was to evaluate the association between lifestyle risk factors, especially physical activity, and prevalence type 2 diabetes comorbidity dyslipidemia in middle-aged Japanese urban population. Subjects (279 males 119 females, 53.5+/-6.8 years old) were selected from one city office Tokyo consisted cases (n=53), (n=130), (n=58) sex- age-matched controls (n=155). A self-administered questionnaire used collect activity data using Baecke's translated other data....
In recent years, radiofrequency catheter ablation(RFCA) has been established as an effective therapy for idiopathic premature ventricular contractions (PVCs), however, its effect on the narrow PVCs (QRS duration < 130 msec) with qR pattern in inferior leads, may not fully concluded.Characteristics of 12-lead electrocardiogram (ECG) and electrophysiologic recordings were analyzed 40 patients symptomatic manifesting QRS complex leads. The procedure RFCA was performed based pace mapping...
Objective To study the serrated lesions of colon and to compare malignant potential between traditional adenomas (TSA )and conventional (CAD). Methods A total 5347 cases colorectal polyps encountered in five regional hospitals during a five-year period were retrospectively reviewed. The classified on basis histologic examination. One hundred eighty-seven CAD (including 160 tubular adenoma 27 villous adenoma)and 36 invasive adenocarcinoma randomly selected as controls. degree dysplasia...
Exon 3 mutation of β-catenin is associated with the carcinogenesis.In this study we aimed to detect expression exon mutations in colorectal TSA, TA/VTA, and CRC.Immunohistochemistry staining for was performed 30 20 tubular adenomas (TA)/villous (VTA), 21 carcinoma (CRC) cases. DNA sequencing gene 8 TSA cases, 6 TA 5 VTA 10 CRC cases positive nuclei cytoplasm.A Fisher exact test chi-square were used analyze differentiations CRC. Results : The percentages 76.6% (23/30), 70.0% (14/20), 95.2%...