A5007382912- Genomics and Phylogenetic Studies
- Helicobacter pylori-related gastroenterology studies
- Cardiovascular Function and Risk Factors
- Neuroscience and Neuropharmacology Research
- Heart Failure Treatment and Management
- Pancreatic function and diabetes
- Chronic Lymphocytic Leukemia Research
- Gastroesophageal reflux and treatments
- Atherosclerosis and Cardiovascular Diseases
- Dialysis and Renal Disease Management
- Congenital Anomalies and Fetal Surgery
- Ocular Surface and Contact Lens
- Streptococcal Infections and Treatments
- Parasitic Infections and Diagnostics
- Blood Pressure and Hypertension Studies
- Liver Disease and Transplantation
- Pharmacological Effects of Natural Compounds
- Neonatal Health and Biochemistry
- Cancer survivorship and care
- Parasitic infections in humans and animals
- Enzyme Production and Characterization
- Intraperitoneal and Appendiceal Malignancies
- Autophagy in Disease and Therapy
- Radiomics and Machine Learning in Medical Imaging
- Ginseng Biological Effects and Applications
Air Force Medical University
2020-2025
Xijing Hospital
2020-2025
Hubei University of Chinese Medicine
2024
Jiangnan University
2023-2024
Tongji Hospital
2018-2024
Southern Medical University
2024
NanoScale Corporation (United States)
2024
Nanosc (Sweden)
2024
Jiangsu University
2024
First Affiliated Hospital of Hebei Medical University
2022-2024
Abstract Aims/Introduction Mitochondrial damage caused by oxidative stress is a main driver of pancreatic β‐cell dysfunction in the pathogenesis type 2 diabetes mellitus. Prohibitin2 (PHB2) vital inner mitochondrial membrane protein that participates mitophagy to remove damaged mitochondria. This study aimed investigate role and mechanisms PHB2‐mediated stress‐induced dysfunction. Materials Methods PHB2 mitophagy‐related expression were analyzed real‐time polymerase chain reaction western...
Reactive astrogliosis and acidosis, common features of epileptogenic lesions, express a high level astrocytic acid-sensing ion channel-1a (ASIC1a), proton-gated cation channel key mediator responses to neuronal injury. This study investigates the role ASIC1a in cognitive impairment following epilepsy. Status epilepticus (SE) C57/BL6 mice was induced using lithium-pilocarpine; impact on astrocytes assessed rAAV-ASIC1a-NC rAAV-ASIC1a-shRNA, injected CA3 region mice. Behavioral assessments were...
It is a critical challenge to diagnose leptomeningeal metastasis (LM), given its technical difficulty and the lack of typical symptoms. The existing gold standard diagnosing LM use positive cerebrospinal fluid (CSF) cytology, which consumes significantly more time classify cells under microscope.This study aims establish deep learning model cancer in CSF, thus facilitating doctors achieve an accurate fast diagnosis early stage.The laboratory Xijing Hospital provides 53,255 from 90 patients...
Purpose: To explore the effect of calcium peroxide nanoparticles (CaO 2 NPs) combined with programmed cell death protein 1 (PD-1) inhibitors in treatment liver cancer and its related mechanism. Methods: Hepa1-6 cells were cultured to construct mouse model. In vivo mechanism study, a unilateral tumor model was established. Eighteen tumor-bearing mice randomly divided into control group (intra-tumoral injection PBS solution) experimental CaO NPs). A hypoxic probe, pH micro-CT used evaluate NPs...
Nao-an Dropping Pill (NADP) is a Chinese patent medicine which commonly used in clinic for ischemic stroke (IS). However, the material basis and mechanism of its prevention or treatment IS are unclear, then we carried out this study. 52 incoming blood components were resolved by UHPLC-MS/MS from rat serum, including 45 prototype components. The potential active hydroxysafflor yellow A, ginsenoside F1, quercetin, ferulic acid caffeic screened network pharmacology showed strongly binding...
Neurocysticercosis (NCC) is the most common parasitic disease of human central nervous system (CNS). However, a diagnosis NCC may be hard to make if specific clinical and routine neuroimaging manifestations are lacking, which hinders physicians from considering further immunodiagnostic tests. Seven patients presented with fever, headache, nausea, cognitive decline, confusion, or progressive leg weakness. There were no pathogens found in cerebrospinal fluid (CSF); clinically suspected...
Abscisic acid (ABA) receptor pyrabactin resistance 1/PYR1-like/regulatory components of ABA proteins (PYR/PYL/RCARs) have been demonstrated to play pivotal roles in signaling and response diverse environmental stimuli including drought, salinity osmotic stress Arabidopsis. However, whether how GhPYL9-5D GhPYR1-3A, the homologues Arabidopsis PYL9 PYR1 cotton, function responding abiotic stresses are still unclear.GhPYL9-5D GhPYR1-3A were targeted cytoplasm nucleus. Overexpression wild type...
Background: Patients with Wilson disease (WD) progress to cirrhosis at an early age but have good prognoses.This study aimed delineate hepatic features in WD patients or without cirrhosis.Methods: Medical data were retrospectively collected from 27 July 2015 June 2018.WD divided into two groups based on whether not they progressed cirrhosis.Liver function, portal hypertension and hematocytopenia rates compared between groups. Results:The enrolled 119 53 cirrhosis.There no differences for...
Blood pressure (BP) is a known prognostic marker for mortality in patients on maintenance hemodialysis (MHD). However, definition of the BP and its optimal values vary essentially among different MHD populations. Our purpose was to clarify these important clinical parameters Chinese cohort. Accordingly, we reviewed available records regular during past 10 years made comparison between deceased (n=81) survival ones (n=131). Multiple logistic regression Kaplan-Meier analysis were used examine...
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This study aimed to assess the effect of blood pressure (BP) index, in terms level and variability, on progression cardiovascular renal diseases patients with both heart failure (HF) chronic kidney disease (CKD).The involved HF CKD from database Chronic Renal Insufficiency Cohort (CRIC) study. The endpoint includes following: (i) primary endpoint, including (CVD) events, all-cause death; (ii) CVD events; (iii) (iv) death. Among 3939 participants CRIC study, a total 382 were included....
The plasticity of vascular smooth muscle cells (VSMCs) enables them to alter phenotypes under various physiological and pathological stimuli. alteration VSMC phenotype is a key step in diseases, including atherosclerosis. Although the transcriptome shift during has been intensively investigated, uncovering multiple regulatory signalling pathways, translatome dynamics this cellular process, remain largely unknown. Here, we explored genome-wide regulation at translational level human VSMCs...
Patients with cirrhosis are known to develop small bowel mucosal lesions. However, the occurrence of lesions in patients abnormal liver function test results absence chronic disease has not been fully evaluated. This study aims examine association between endoscopic and dysfunction without confirmed disease.Two hundred ninety six consecutive who met selection criteria underwent capsule endoscopy. The severity intestinal was evaluated quantitatively using Lewis scoring system, hepatic an...
Abstract Aims/Introduction This study was carried out to investigate the relationship of stressful life events (SLEs) with risk cognitive impairment in patients type 2 diabetes mellitus. Materials and Methods A total 316 mellitus aged >45 years were recruited this study, data on demographics, medical history, lifestyle characteristics SLEs collected. The status evaluated a battery function scales. Logistic regression analyses evaluate protective factors for mild (MCI). Results...