A5076617776- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Organometallic Complex Synthesis and Catalysis
- Cyclopropane Reaction Mechanisms
- Synthetic Organic Chemistry Methods
- Catalytic Alkyne Reactions
- Asymmetric Hydrogenation and Catalysis
- Ferroelectric and Negative Capacitance Devices
- Advanced Memory and Neural Computing
- Metal complexes synthesis and properties
- Synthesis and biological activity
- Metal-Organic Frameworks: Synthesis and Applications
- Ferroelectric and Piezoelectric Materials
- Gold and Silver Nanoparticles Synthesis and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Antifungal resistance and susceptibility
- Carbon dioxide utilization in catalysis
- Ferrocene Chemistry and Applications
- Chemical Synthesis and Analysis
- Semiconductor materials and devices
- Magnetism in coordination complexes
- Electronic and Structural Properties of Oxides
- Microbial Natural Products and Biosynthesis
- Lung Cancer Diagnosis and Treatment
Xi'an Jiaotong University
2019-2024
Sun Yat-sen University
2021-2023
Eternity Bioscience (United States)
2021-2022
Sun Yat-sen University Cancer Center
2021-2022
Hangzhou First People's Hospital
2022
University of California, Los Angeles
2007-2021
China XD Group (China)
2019
Merck & Co., Inc., Rahway, NJ, USA (United States)
2011-2015
Hebei Normal University of Science and Technology
2013-2014
Luye Pharma (China)
2013
A concise synthesis of both enantiomers ligand 2 and rhodium complex 5 is presented. The crux the a chiral HPLC separation 4. Rhodium possesses three hindered quadrants in steric environment within which substrate binds. Evidence presented that this configuration leads to high enantioselectivity (>99% ee) for rhodium-catalyzed asymmetric hydrogenation alpha-acetamido dehydroamino acids, 6a-e. High enantioselectivities are also reported precursor, 8, pharmaceutical candidate, pregabalin....
The ambidentate ligand 5,5′-dicyano-2,2′-bipyridine (L) was found to function as a bi-, tri- or tetra-dentate chelate chelate/bridging in the co-ordination of silver ions. mode depends on anion and crystallization conditions elucidated by single crystal X-ray diffractometry. With metal-co-ordinating anions such NO3– CF3SO3– tridentate L is observed which involves two bipyridine nitrogen donor atoms one cyano group. latter bridges neighboring center so that one-dimensional polymer results....
The potential in a synaptic simulation for neuromorphic computation has revived the research interest of resistive random access memory (RRAM). However, novel applications require reliable multilevel switching (RS), which still represents challenge. We demonstrate this work achievement HfO2-based RRAM devices by performing Al doping and postdeposition annealing (PDA). Transmission electron microscopy operando hard X-ray photoelectron spectroscopy results reveal positive impact on formation...
The mode of co-ordination the multidentate ligand 2,2′-dimethyl-4,4′-bipyrimidine (L) was found to depend on metal ion, crystallization conditions, metal-to-ligand ratio, and anion. With nickel a chelating through endo-dentate nitrogen donor set is observed in molecular complex [NiCl2(L)(H2O)]·CH3NO2, derived from hot CH3NO2. Cu(NO3)2 CuI–CH3CN one- two-dimensional (1-D 2-D) polymers formula ∞ 1[Cu(NO3)2(µ-L)] 2[Cu2(µ3-I)2(µ-L)] are obtained, where bipyrimidine solely bridging two...
O<sub>3</sub>-based interface engineering dominates implementations of analog memory and synaptic simulation using reliable Pt/HfO<sub>2</sub>/TiN RRAM.
A previously reported three-hindered quadrant chiral ligand and its corresponding rhodium complex provide high enantioselectivity for the asymmetric hydrogenation of β-acetamido dehydroamino acid substrates. Both (E)- (Z)-substrates are hydrogenated with in all examples. Asymmetric a cyclic substrate 85% ee is also reported.
We investigated the switching performance of Cu-oxide films with Al, Pt, and Ti electrodes. Compared Pt electrode, Al electrode shows better stability, preferable endurance, larger resistance ratio. An interface AlOx layer is detected by transmission electron microscopy Auger spectroscopy. This can strongly affect movement oxygen vacancies. However, sample pure almost has no characteristics. Ti/TiN thin exhibits good behavior. The thickness control quite critical. So we suggest that...
Abstract The manipulation of acoustic waves plays an important role in a wide range applications. Currently, wave typically relies on either metasurfaces or phased array transducers. elements traditional are usually designed with complex artificial structures and limited by the additive manufacturing capability, which difficult to apply MHz frequency underwater control. Phased transducers, suffering from high‐cost control circuits, size filling ratio units. Coding piezoelectric reported;...
The quantitative and highly sensitive detection of biomarkers such as Tau proteins Aβ polypeptides is considered one the most effective methods for early diagnosis Alzheimer's disease (AD). Surface-enhanced Raman spectroscopy (SERS) a promising method that faces, however, challenges like insufficient sensitivity due to non-optimized nanostructures specialized analyte sizes control location SERS hot spots. Thus, AD restricted. We reported here an in-depth study analytical enhancement factor...
A new synthetic route for the synthesis of 5,5′-diamino-2,2-bipyridine (5) based on coupling 2-chloro-5-aminopyridine in presence NiCl2 × 6 H2O/PPh3/Zn dimethylformamide is described. The reactions potentially ambidentate ligand 5 with salts transition metals Mn, Fe, Ni, Cu, Zn, Ag, and Cd gave a variety 13 metal–ligand complexes depending anion, crystallization conditions metal-to-ligand ratio. obtained were characterized by thermal analyses, NMR including 113Cd-NMR, IR, iron complex...
Seven new iridabenzenes were prepared by the addition of (Z)-1,2-diphenyl-3-(2-lithioethenyl)-1-cyclopropene to Vaska-type complexes [IrCl(CO)(PR3)2], containing differing phosphine ligands. The could be isolated from reaction mixture either direct means or after heating crude solution. In case reactions using PMe3 and PEt3, a σ-vinyl/η2-cyclopropene Ir(I) complex, best described as an iridabenzvalene, fully characterized. metallabenzvalene intermediate cleanly converted corresponding...
A member of the Janus kinase (JAK) family, Tyrosine Kinase 2 (TYK2), is crucial in mediating various cytokine-signaling pathways such as interleukin-23 (IL23), interleukin-12 (IL12) and type I Interferons (IFN) which contribute to autoimmune disorders (e.g., psoriasis, lupus, inflammatory bowel disease). Thus, TYK2 represents an attractive target develop small-molecule therapeutics for treatment cytokine-driven diseases. Selective inhibition over other JAK isoforms critical achieve a...
The synthesis of unsymmetrical (Z)-1-alkyl-3-(2-iodovinyl)-2-phenyl-1-cyclopropenes (R=Me (8 a), Et b), iPr c), and tBu d)) their reactions with Vaska's complex [Ir(CO)Cl(PPh3)2] its trimethylphosphine analogue [Ir(CO)Cl(PMe3)2] were investigated. Iridabenzvalene (13/20), iridabenzene (14/21), and/or eta(5)-cyclopentadienyliridium complexes (15/22) obtained in modest yields fully characterized by spectroscopic means. X-ray structural data was secured for iridabenzvalene 13 d iridabenzenes 14...
The reaction of (Z)-1-phenyl-2-(trimethylsilyl)-3-(2-lithiovinyl)cyclopropene (4) with Vaska's complex generates the iridabenzvalene 8, iridabenzene 9, and cyclopentadienyl 10 in a 10:2:3 ratio. Heating this mixture to 75 °C converts 8 9 10. NMR studies over 24 h period at show that samples containing pure isomerize high yield generate regioisomeric 11 as an intermediate.
Cobalt(II), zinc(II) and cadmium(II) salts react with the new spacer ligand 2,2′-bi-1,6-naphthyridine 1 to give 2D-planar (4,4) frameworks which interpenetrate such that each grid window of sheet has two other sheets passing through it all being equivalent whereas copper(I) tetrafluoroborate form a 21-helicoidal chain neigboring chains interlocking an aromatic π–π interaction.
Lithium−halogen exchange of either (Z)-1-phenyl-2-trimethylsilyl- (5a) or (Z)-1,2-bis(trimethylsilyl)-3-(2-iodovinyl)cyclopropene (5b) and addition to Vaska's Vaska-type complexes generated iridabenzvalenes (9, 14, 17), iridabenzenes (10, 18), and/or cyclopentadienyl (11, 15, 19), depending on both the substituents C5 framework phosphine ligands Ir. Specifically, reaction 5a with complex afforded a mixture 9, 10, 11. Heating this 75 °C converted 9 10 NMR studies at showed that samples...
CD73 and adenosine support growth-promoting neovascularization, metastasis, survival in cells, promote anti-PD-1 mAb therapy-induced immune escape. Consequently, developing a inhibitor as monotherapy potential beneficial combination partner with immune-checkpoint inhibitors needs investigation.CD73 were evaluated vitro soluble membrane-bound enzymes, well its PD biomarker responses human peripheral blood mononuclear cells (PBMC) by flow cytometry ELISA. The binding modes of the molecules...
Large-scale close-packed two-dimensional (2D) colloidal crystal with high coverage is indispensable for various promising applications. The Langmuir–Blodgett (LB) method a powerful technique to prepare 2D crystals. However, the self-assembly and movement of microspheres during whole LB process are less analyzed. In this study, we clarify crucial impact hydrophilicity on their in properties prepared characteristic surface pressure–area isotherms have been analyzed adjusted by only counting...
It is a critical challenge to diagnose leptomeningeal metastasis (LM), given its technical difficulty and the lack of typical symptoms. The existing gold standard diagnosing LM use positive cerebrospinal fluid (CSF) cytology, which consumes significantly more time classify cells under microscope.This study aims establish deep learning model cancer in CSF, thus facilitating doctors achieve an accurate fast diagnosis early stage.The laboratory Xijing Hospital provides 53,255 from 90 patients...