A5033972981- Gold and Silver Nanoparticles Synthesis and Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Advanced biosensing and bioanalysis techniques
- Protein Interaction Studies and Fluorescence Analysis
- Pickering emulsions and particle stabilization
- Graphene research and applications
- Lipid Membrane Structure and Behavior
- Plasmonic and Surface Plasmon Research
- Quantum Dots Synthesis And Properties
- Spectroscopy and Chemometric Analyses
- Cardiomyopathy and Myosin Studies
- Surfactants and Colloidal Systems
- AI in cancer detection
- Advanced Nanomaterials in Catalysis
- Orthopaedic implants and arthroplasty
- Semiconductor materials and devices
- Orbital Angular Momentum in Optics
- Graphene and Nanomaterials Applications
- Medical Imaging and Pathology Studies
- Carbon Nanotubes in Composites
- Microfluidic and Bio-sensing Technologies
- Advancements in Semiconductor Devices and Circuit Design
- Electrochemical sensors and biosensors
- Material Dynamics and Properties
- Field-Flow Fractionation Techniques
University of California, Los Angeles
2011-2020
Xi'an Jiaotong University
2018
UCLA Jonsson Comprehensive Cancer Center
2016
University of Colorado Denver
2016
University of Colorado Cancer Center
2016
California NanoSystems Institute
2012-2015
A graphene-Au nano-pyramid hybrid system that enables label-free single molecule detection is demonstrated. The bio-compatible graphene-based SERS platform boosts a high density of hot spots with local enhancement factor over 1010. We demonstrate graphene can play key role in quantitative study mechanisms, and also serve as promising building block active structures especially for biosensor applications.
Ultrasensitive detection and spatially resolved mapping of neurotransmitters, dopamine serotonin, are critical to facilitate understanding brain functions investigate the information processing in neural networks. In this work, we demonstrated single molecule serotonin using a graphene–Au nanopyramid heterostructure platform. The quasi-periodic Au structure boosts high-density high-homogeneity hotspots resulting ultrahigh sensitivity with surface enhanced Raman spectroscopic (SERS)...
The unique properties of graphene when coupled to plasmonic surfaces render a very interesting physical system with intriguing responses stimuli such as photons. It promises exciting application potentials photodetectors well biosensing. With its semimetallic band structure, in the vicinity metallic nanostructures is expected lead non-negligible perturbation local distribution electromagnetic field intensity, an resonance process that has not been studied sufficient extent. Efforts enhance...
Abstract A strongly confined and enhanced electromagnetic (EM) field due to gap‐plasmon resonance offers a promising pathway for ultrasensitive molecular detections. However, the maximum portion of EM is commonly concentrated within dielectric gap medium that inaccessible external substances, making it extremely challenging achieving single‐molecular level detection sensitivity. Here, new family plasmonic nanostructure created through unique process using nanoimprint lithography introduced,...
Amyloid β-protein (Aβ) self-association is one process linked to the development of Alzheimer's disease (AD). Aβ peptides, including its most abundant forms, Aβ40 and Aβ42, are associated with two predominant neuropathologic findings in AD, vascular parenchymal amyloidosis, respectively. Efforts develop therapies for AD often have focused on understanding controlling assembly these peptides. An obligate step efforts monitoring state. We show here that surface-enhanced Raman spectroscopy...
We report systematic transient characterization of a graphene ribbon (GR) used as an interconnect for electrostatic discharge (ESD) protection future integrated circuits. A large set GR wires (around 6000) with varying and practical dimensions were fabricated using the chemical vapor deposition method characterized by transmission line pulsing (TLP) very fast TLP (VFTLP) measurements. Comprehensive VFTLP testing pulse rise time ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Large-scale close-packed two-dimensional (2D) colloidal crystal with high coverage is indispensable for various promising applications. The Langmuir–Blodgett (LB) method a powerful technique to prepare 2D crystals. However, the self-assembly and movement of microspheres during whole LB process are less analyzed. In this study, we clarify crucial impact hydrophilicity on their in properties prepared characteristic surface pressure–area isotherms have been analyzed adjusted by only counting...
Manipulation of biomolecules in aqueous solution has been a critical issue for the development many biosensing techniques and biomedical devices. Electrostatic force is an effective method increasing both sensitivity selectivity various techniques. In this study, we employed surface-enhanced Raman spectroscopy (SERS) as situ label-free to monitor motion driven by manipulation technique. We present results combined experimental simulation study demonstrate that electrostatic could enhance...
Abstract Surface enhanced Raman spectroscopy (SERS) holds great promise in biosensing because of its single‐molecule, label‐free sensitivity. We describe here the use a graphene–gold hybrid plasmonic platform that enables quantitative SERS measurement. Quantification is enabled by normalizing analyte peak intensities to graphene G peak. show two complementary quantification modes are intrinsic features and through their combined use, accurate determination concentration over range spanning...
In article number 1801146, Peng Zhan, Wei Wu, Zhenlin Wang, and co-workers create a plasmonic nanostructure through unique process using ultrathin tetrahedral amorphous carbon deposition nanofingers collapse, which enables the precise tailoring of gap plasmon modes to realize strong spill-out enhanced electromagnetic field. The resulting device can achieve chemical detection at single-molecular level while having high areal density hotspots in free space.