A5066083607- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Cerebrospinal fluid and hydrocephalus
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Meningioma and schwannoma management
- Acute Ischemic Stroke Management
- Pituitary Gland Disorders and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Parasites and Host Interactions
- Cerebrovascular and Carotid Artery Diseases
- Parasitic infections in humans and animals
- Facial Nerve Paralysis Treatment and Research
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Neuroinflammation and Neurodegeneration Mechanisms
- Ferroptosis and cancer prognosis
- Histone Deacetylase Inhibitors Research
- Neonatal and fetal brain pathology
- Fetal and Pediatric Neurological Disorders
- Bioinformatics and Genomic Networks
- Trigeminal Neuralgia and Treatments
- Cancer-related molecular mechanisms research
- Atherosclerosis and Cardiovascular Diseases
- Parasite Biology and Host Interactions
Renmin Hospital of Wuhan University
2015-2023
Wuhan University
2011-2023
Wuchang University of Technology
2019
Hypoxia-induced M2 phenotypes of tumor associated macrophages (TAMs) promote the development and chemoresistance multiple types cancers, including glioblastoma (GBM). However, detailed molecular mechanisms have not been fully understood. In this study, we firstly reported that hypoxic pressure promoted macrophage generation, which further cancer progression temozolomide (TMZ) resistance in GBM through secreting vascular endothelial growth factor (VEGF). Specifically, clinical data suggested...
Ischemic stroke (IS) is a type of that leads to high mortality and disability. Anoikis form programmed cell death. When cells detach from the correct extracellular matrix, anoikis disrupts integrin junctions, thus preventing abnormal proliferating growing or attaching an inappropriate matrix. Although there evidence regulates immune response, which makes great contribution development IS, role in pathogenesis IS rarely explored.First, we downloaded GSE58294 set GSE16561 NCBI GEO database....
Spontaneous supratentorial intracerebral hemorrhage (SSICH) is one of the deadliest diseases, and neuroendoscopic surgery (NE) a minimally invasive promising treatment that might improve functional recovery patients. This study analyzed patient's experience with this in terms safety, efficacy, surgical technique.Forty-two patients SSICHs treated by transcranial approach were retrospectively reviewed from June 2016 to July 2018 our department. Patients classified into four groups according...
Objective: To evaluate the effectiveness and safety of neuroendoscopic surgery for chronic or subacute subdural hematoma. Patients methods: Between September 2016 2018, was performed on 25 patients with Hematoma evacuation a 0°, 4 mm diameter rigid neuroendoscope via transcranial approach. Results: All successfully underwent surgery, no surgical complications rebleeding observed. Postoperative computed tomography scans showed that hematoma evacuated. had recovered well at discharge, observed...
Hemorrhagic stroke (HS) is usually treated under microscopy, but recently, an increasing number of cases have been neuroendoscopy. The objective this study was to explore the feasibility and efficacy a transcranial neuroendoscopic approach for HS. Based on etiology clinical features, 203 HS patients were classified into two groups, with 100 in primary (PHS) group 103 secondary (SHS) group. All either by full neuroendoscopy (FNE) or combined microsurgery (ECM). Outcomes assessed according...
Bioinformatics methods were applied to investigate the pivotal genes and regulatory networks associated with atherosclerotic carotid artery stenosis (ACAS) provide new insights for treatment of this disease.
To evaluate the effectiveness and safety of microvascular decompression (MVD) using a fully transcranial neuroendoscopic approach.Thirty-one patients who underwent MVD approach in our department between May 2016 September 2019 were retrospectively reviewed.All successfully MVD, immediate pain relief was achieved all 17 cases trigeminal neuralgia (TGH) 3 glossopharyngeal (GPN). Hemifacial spasm (HFS) completely resolved 11 patients. No mortality or permanent complication seen.The endoscope is...
Abstract Rationale: Posterior inferior cerebellar artery (PICA) aneurysms are rare and heterogeneous in both location morphology, the management of proximal PICA is challenging. In 2011, Joaquim reported a successfully treated VA-PICA ruptured aneurysm using pure endoscopic endonasal transclival approach for first time. However, patient suffered CSF rhinorrhea underwent an additional operation to repair leak. this case report, we describe treatment by transcranial neuroendoscopic approach....
Abstract Rationale: Anterior clinoidectomy is an important technique for neurovascular and skull base surgery. Until now, extradural anterior clinoidectomies have been performed under a microscope in almost all clinical cases, with only one case pathological clinoid process resection using neuroendoscopy. Additionally, no normal ACP resections extradurally via neuroendoscopy, especially aneurysms. We tried to perform by Patient concerns: A 63-year-old woman was admitted hospital presented...
Rationale: Basal ganglia hematomas resulting from the rupture of aneurysms distal middle cerebral artery (MCA) are extremely rare and usually treated by craniotomy. To date, only 5 cases MCA aneurysm have been using neuroendoscopy, none these involved hematomas. For first time, we report a special case in which neuroendoscopy was used to evacuate hematoma clip an at same time. Patient concerns: A massive basal 60-year-old man evacuated discovered clipped successfully under during operation....
Traditionally, cerebral arteriovenous malformations (cAVMs) are surgically treated with microscopy, and no cases receive full neuroendoscopy. We operated on two small cAVMs hematoma under a neuroendoscope, the patients obtained excellent results.To explore feasibility of treating transcranial neuroendoscopic approach.The clinical data operative techniques were collected described for who diagnosed via approach.In patients, hematomas successfully evacuated, AVMs removed simultaneously; both...
Abstract Introduction : Lesions located in the fourth ventricle and/or pontine tegmentum were treated by telovelar approach under a microscope. However, it is difficult to access upper from caudal rostral without removal posterior arch of atlas due vertical working angle Neuroendoscope has good degree freedom surgery and can reach this area easily. We tried remove cavernous malformation full neuroendoscopic results was excellent. Clinical Presentation Two women presented with dizziness...