A5038112485- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Transportation and Mobility Innovations
- Connective tissue disorders research
- Moyamoya disease diagnosis and treatment
- Smart Grid Energy Management
- Transportation Planning and Optimization
- Sharing Economy and Platforms
- Mitochondrial Function and Pathology
- Green IT and Sustainability
- Electric Vehicles and Infrastructure
- Urban and Freight Transport Logistics
- Cervical and Thoracic Myelopathy
- Spatial Neglect and Hemispheric Dysfunction
- Cardiovascular Issues in Pregnancy
- Human Mobility and Location-Based Analysis
- Congenital heart defects research
- ATP Synthase and ATPases Research
- Advanced Battery Technologies Research
- Stroke Rehabilitation and Recovery
- Big Data and Business Intelligence
- Metabolism and Genetic Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Reconstructive Surgery and Microvascular Techniques
Suva
2017-2025
University of Münster
2021-2024
European Research Center for Information Systems
2023-2024
Erasmus University Rotterdam
2016-2023
HES-SO Valais-Wallis
2022
Carl von Ossietzky Universität Oldenburg
2022
Oldenburger Institut für Informatik
2022
University of Twente
2022
University of Luxembourg
2022
Rotterdam University of Applied Sciences
2020
Background and Purpose-Data on risk factors for etiologic subtypes of ischemic stroke are still scant.The aim this study was to characterize regarding factor profile, outcome, current treatment strategies.Methods-We analyzed data from 5017 patients with acute (42.4% women, aged 65.9Ϯ14.1 years) who were enrolled in a large multicenter hospital-based bank.Standardized assessment subtype classification used by all centers.Results-Sex age distribution, major comorbidities, recurrent stroke,...
Background and Purpose Thrombolysis may reduce mortality after acute basilar artery (BA) occlusion. We intended to find variables affecting recanalization clinical outcome in patients with BA occlusion undergoing thrombolytic therapy. Methods analyzed retrospect the angiographic data of a consecutive series 51 treated intra-arterial urokinase (n=44; 0.3 1.5 mIU) or intravenous recombinant tissue plasminogen activator (n=7; 22 100 mg). identified effective by multiple logistic regression...
Mitochondria form a dynamic network within the cell as result of balanced fusion and fission. Despite established role mitofusins (MFN1 MFN2) in mitochondrial fusion, only MFN2 has been associated with metabolic neurodegenerative diseases, which suggests that is needed to maintain energy metabolism. The molecular basis for dysfunction encountered absence not understood. Here we show loss leads impaired respiration reduced ATP production, this defective oxidative phosphorylation process...
Inflammatory markers predict first-time ischemic events. We investigated whether leukocyte and differential counts recurrent events in high-risk populations, such are preceded by acutely exacerbated inflammation.We studied 18 558 patients with stroke, myocardial infarction, or peripheral arterial disease who participated the trial of Clopidogrel versus Aspirin Patients at Risk Ischemic Events (CAPRIE), a study that compared occurrence vascular death under randomized treatment aspirin...
<b><i>Background:</i></b> The etiology of spontaneous cervical artery dissection (CAD) is largely unknown. An underlying connective tissue disorder has often been postulated. <b><i>Objective:</i></b> To further assess the association CAD with ultrastructural abnormalities dermal tissue. <b><i>Methods:</i></b> In a multicenter study, skin biopsies 65 patients proven nontraumatic and 10 control subjects were evaluated. morphology components was assessed by transmission electron microscopy....
Abstract The cause of spontaneous cervicocerebral artery dissection is unknown. An underlying arteriopathy due to a connective tissue disorder has often been presumed. We studied 25 patients with proven nontraumatic dissections. ultrastructural morphology dermal components was assessed by transmission electron microscopy skin biopsies. Ultrastructural abnormalities were seen in 17 (68%) patients, resembling some cases the aberrations found Ehlers‐Danlos syndrome type II or III. These...
To examine whether risk factor profile, baseline features, and outcome of cervical artery dissection (CEAD) differ according to the site.We analyzed 982 consecutive patients with CEAD included in Cervical Artery Dissection Ischemic Stroke Patients observational study (n = 619 internal carotid [ICAD], n 327 vertebral [VAD], 36 ICAD VAD).Patients were older (p < 0.0001), more often men 0.006), frequently had a recent infection (odds ratio [OR] 1.59 [95% confidence interval (CI) 1.09-2.31]),...
Background and Purpose —It has been shown that thrombolytic therapy can improve clinical outcome in a subgroup of patients with acute cerebral ischemia. This was characterized by certain imaging findings (eg, moderate to severe neurological deficit for less than 3 6 hours, occlusion the middle artery, lack extended infarct signs on CT, efficient leptomeningeal collaterals). Although not part published prospective randomized rtPA trials, information about status brain vessels would be helpful...
To examine the import of prior cervical trauma (PCT) in patients with artery dissection (CeAD).In this observational study, presence and type PCT were systematically ascertained CeAD using 2 different populations for comparisons: 1) age- sex-matched ischemic stroke attributable to a cause other than (non-CeAD-IS), 2) healthy subjects participating Cervical Artery Dissection Ischemic Stroke Patients Study. The within 1 month was assessed standardized questionnaire. Crude odds ratios (ORs) 95%...
Ageing is a progressive decline of intrinsic physiological functions. We examined the impact ageing on ultrastructure and function mitochondria in mouse fruit flies (Drosophila melanogaster) by electron cryo-tomography respirometry. discovered distinct age-related changes both model organisms. Mitochondrial are maintained heart, whereas subpopulations from liver show membrane morphology. Subpopulations young old kidney resemble those described for apoptosis. In aged flies, respiratory...
Fusion of mitochondrial outer membranes is crucial for proper organelle function and involves large GTPases called mitofusins. The discrete steps that allow mitochondria to attach one another merge their are unknown. By combining an in vitro fusion assay with electron cryo-tomography (cryo-ET), we visualize the junction between attached isolated from Saccharomyces cerevisiae observe complexes mediate this attachment. We find cycles GTP hydrolysis induce progressive formation a docking ring...
Defects of the oxidative phosphorylation system, in particular cytochrome-c oxidase (COX, respiratory chain complex IV), are common causes Leigh syndrome (LS), which is a rare neurodegenerative disorder with severe progressive neurological symptoms that usually present during infancy or early childhood. The COX-deficient form LS commonly caused by mutations genes encoding COX assembly factors, e.g. SURF1, SCO1, SCO2 COX10. However, other affecting encode proteins not directly involved can...
Public transport operators (PTOs) increasingly face a challenging problem in switching from conventional diesel to more sustainable battery electric buses (BEBs). In this study, we optimize the opportunity fast-charging schedule of transit BEB networks order minimize charging costs and impact on grid. Two mixed-integer linear programming (MILP) formulations that use different discretization approaches are developed compared. Discrete-Time Optimization (DTO) resembles time-expanded network...
Several small to medium-sized studies indicated a link between cervical artery dissection (CeAD) and migraine. Migrainous CeAD patients were suggested have different clinical characteristics compared nonmigraine patients. We tested these hypotheses in the large Cervical Artery Dissection Ischemic Stroke Patients (CADISP) population.A total of 968 653 with an ischemic stroke cause other than (non-CeAD IS) recruited. (CeAD(stroke), n = 635) non-CeAD IS regarding migraine, characteristics,...
To examine whether thrombolysis for stroke attributable to cervical artery dissection (CeAD(Stroke) ) affects outcome and major haemorrhage rates.We used a multicentre CeAD(Stroke) database compare patients treated with without thrombolysis. Main measures were favourable 3-month (modified Rankin Scale 0-2) 'major haemorrhage' [any intracranial (ICH) extracranial haemorrhage]. Adjusted odds ratios [OR (95% confidence intervals)] calculated on the whole propensity-matched groups.Among 616...
<h3>Objective:</h3> In a large series of patients with cervical artery dissection (CeAD), major cause ischemic stroke in young and middle-aged adults, we aimed to examine frequencies correlates family history CeAD inherited connective tissue disorders. <h3>Methods:</h3> We combined data from 2 international multicenter cohorts consecutive 23 neurologic departments participating the CADISP-plus consortium, following standardized protocol. Frequency reported disorders was assessed. Putative...
Urban mobility is currently undergoing three fundamental transformations with the sharing economy, electrification, and autonomous vehicles changing how people goods move across cities. In this paper, we demonstrate valuable contribution of decision support systems that combine data-driven analytics simulation techniques in understanding complex such as urban transportation. Using city Berlin a case study, show shared, electric can substantially reduce resource investments while keeping...
Background and Purpose —Both Doppler sonography (DS) spiral CT angiography (CTA) are noninvasive vascular assessment tools with a high potential for application in acute cerebral ischemia. The usefulness of CTA diagnosis basilar artery (BA) ischemia has not yet been studied. Methods —We prospectively studied 19 patients (mean±SD age, 58±11 years) clinically suspected BA occlusion by DS CTA. Prior extracranial transcranial was performed all but 1 patient, 4 hours after In 6 patients, we...