A5033477592- Connective tissue disorders research
- Dermatological and Skeletal Disorders
- Blood Pressure and Hypertension Studies
- Inorganic Fluorides and Related Compounds
- Aortic aneurysm repair treatments
- Peptidase Inhibition and Analysis
- Hormonal Regulation and Hypertension
- Solid-state spectroscopy and crystallography
- Advanced optical system design
- Aortic Disease and Treatment Approaches
- Venous Thromboembolism Diagnosis and Management
- Vascular Malformations and Hemangiomas
- Obstructive Sleep Apnea Research
- Photonic and Optical Devices
- Wnt/β-catenin signaling in development and cancer
- Cardiovascular Health and Disease Prevention
- Advanced Chemical Physics Studies
- Molecular Spectroscopy and Structure
- Skin and Cellular Biology Research
- Semiconductor materials and interfaces
- Dental Radiography and Imaging
- Dupuytren's Contracture and Treatments
- Cardiovascular Issues in Pregnancy
- Cardiovascular Syncope and Autonomic Disorders
- Facial Trauma and Fracture Management
University Medical Center Utrecht
2013-2024
Medisch Centrum Haaglanden
2019-2024
Netherlands Comprehensive Cancer Organisation
2024
GGD Haaglanden
2023
Hôpital Européen Georges-Pompidou
2014-2023
Paris Cardiovascular Research Center
2011-2023
Université Paris Cité
2011-2023
Assistance Publique – Hôpitaux de Paris
2013-2023
Inserm
2012-2023
Sorbonne Paris Cité
2013-2023
The Ehlers-Danlos syndromes (EDS) are a clinically and genetically heterogeneous group of heritable connective tissue disorders (HCTDs) characterized by joint hypermobility, skin hyperextensibility, fragility. Over the past two decades, Villefranche Nosology, which delineated six subtypes, has been widely used as standard for clinical diagnosis EDS. For most these mutations had identified in collagen-encoding genes, or genes encoding collagen-modifying enzymes. Since its publication 1998,...
To compare two drug regimens to treat resistant hypertension.In a prospective, randomized, open blinded endpoint study, 167 patients with mean baseline daytime ambulatory blood pressure 135 mmHg or more and/or 85 more, despite 4 weeks' treatment irbesartan 300 mg/day, hydrochlorothiazide 12.5 mg/day and amlodipine 5 were randomized sequential nephron blockade (group 1, n = 85) renin-angiotensin system 2, 82). First, spironolactone 25 in group 1 ramipril 2 added for weeks. Treatment was...
Objectives: To evaluate the effectiveness of adalimumab in patients with psoriatic arthritis (PsA) and identify predictors good clinical response for joint skin lesions. Methods: Patients received 40 mg every other week addition to standard therapy this prospective, 12-week, open-label, uncontrolled study. Four definitions were used: ⩾50% improvement American College Rheumatology criteria (ACR50), according European League Against Rheumatism (EULAR) guidelines, a ⩾3-grade Physician Global...
<h3>Objective:</h3> In a large series of patients with cervical artery dissection (CeAD), major cause ischemic stroke in young and middle-aged adults, we aimed to examine frequencies correlates family history CeAD inherited connective tissue disorders. <h3>Methods:</h3> We combined data from 2 international multicenter cohorts consecutive 23 neurologic departments participating the CADISP-plus consortium, following standardized protocol. Frequency reported disorders was assessed. Putative...
Arterial stiffness is related to age and collagen properties of the arterial wall can be indirectly evaluated by pulse wave velocity (PWV). Ultrafast ultrasound imaging, a unique ultrahigh frame rate technique (>10, 000 images/s), recently emerged enabling direct measurement carotid PWV its variation over cardiac cycle. Our goal was characterize diastolic-systolic stiffening using ultrafast imaging in healthy individuals vascular Ehlers-Danlos syndrome (vEDS), which type III defectuous....
In Part 1 of this two-part article, the Amsterdam Positional Obstructive Sleep Apnoea Classification (APOC) was recently introduced, a classification system aimed at facilitating identification suitable candidates for positional therapy (PT): patients who will benefit from clinically significant improvement their obstructive sleep apnoea (OSA) with PT. APOC developed new generation PT devices in mind rather than conventional (tennis ball technique). New can be defined as well-tolerated...
Abstract Background: Soft-tissue swelling and increased extracellular volume, two features of acromegaly, are related to the antinatriuretic effects excess GH/IGF-I, but precise pathophysiological mechanism is unclear. Objective: Our objective was determine effect GH on renal extrarenal epithelial sodium channel (ENaC) activity. Design Setting: We conducted a prospective randomized open-label blinded-endpoint (PROBE) crossover study (www.ClinicalTrials.gov Identifier: NCT00531908) at...
A soluble (pro)renin receptor (sPRR) circulates in plasma and is able to bind renin prorenin. It not known whether sPRR concentrations vary with the activity of renin-angiotensin system. We measured sPRR, renin, prorenin, aldosterone 121 white 9 black healthy subjects, 40 patients diabetes mellitus, 41 hypertensive or without system blockers, primary aldosteronism, 10 Gitelman syndrome. Median physiological concentration was 23.5 ng/mL (interquartile range, 20.9-26.5) under usual...
Lymph node metastasis (LNM) is a major determinant of prognosis and treatment planning oral squamous cell carcinoma (OSCC). Cysteine cathepsins constitute family proteolytic enzymes with known role in the degradation extracellular matrix. Involvement pathological processes, such as inflammation cancer progression, has been proved. The aim study was to discover clinicopathological prognostic implications cathepsin K (CTSK) expression carcinoma.Eighty-three patients primary OSCC, treated...
Abstract: Keratitis‐ichthyosis‐deafness (KID) syndrome is a rare ectodermal dysplasia, characterized mainly by the presence of hyperkeratotic skin lesions, neurosensory hearing loss, and vascularizing keratitis. Most mutations that have been discovered as cause KID are autosomal dominant, found in exon 2 Connexin (Cx) 26 gene. A G12R (p.Gly12Arg) GJB2 mutation reported only two patients with to date. This article describes patient interesting additional features, which include porokeratotic...
Objectives Can a synthetic bone substitute be used to repair the alveolar cleft bypass donor site morbidity as well shorten operating time? In earlier experimental studies, micro-structured beta-tricalcium phosphate (β-TCP) provided similar healing when compared with grafting iliac crest bone. This justifies clinical evaluation of this in human situation. Design Prospective study. Setting University clinic. Participants Seven patients, all unilateral cleft, were randomly included for β-TCP...
Gene expression profiling revealed a strong signature predicting lymph node metastases in oral squamous cell carcinoma (OSCC). Four of the most predictive genes are secretory leukocyte protease inhibitor (SLPI), lipocalin-2 (LCN2), thrombospondin-2 (THBS2), and tumor-associated calcium signal transducer 2 (TACSTD2). This study correlates their protein with metastases, overall survival (OS), disease-specific (DSS).Two hundred twelve patients OSCC were included for analysis by...