A5047329062- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Fibroblast Growth Factor Research
- Ear and Head Tumors
- Reconstructive Surgery and Microvascular Techniques
- Kruppel-like factors research
- Cancer Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Cancer-related gene regulation
- RNA modifications and cancer
- Reconstructive Facial Surgery Techniques
- Lung Cancer Treatments and Mutations
- Medical Imaging Techniques and Applications
- Tumors and Oncological Cases
- Facial Trauma and Fracture Management
- Radiopharmaceutical Chemistry and Applications
- Bone health and treatments
- Cancer Genomics and Diagnostics
- Bone Tumor Diagnosis and Treatments
- Prostate Cancer Treatment and Research
- Cleft Lip and Palate Research
- Medical Imaging and Pathology Studies
- Cancer-related Molecular Pathways
- Oral health in cancer treatment
University Medical Center Utrecht
2016-2025
Cancer Genomics Centre
2017-2025
Heidelberg University
2015-2024
University Hospital Heidelberg
2015-2024
The Netherlands Cancer Institute
2012-2024
Medisch Centrum Haaglanden
2024
University Medical Center Groningen
2024
Utrecht University
1997-2020
Wilhelmina Children's Hospital
2019
Radboud University Nijmegen
2012-2018
BackgroundOrganoids are in vitro three-dimensional structures that can be grown from patient tissue. Head and neck cancer (HNC) is a collective term used for multiple tumor types including squamous cell carcinomas salivary gland adenocarcinomas.MethodsOrganoids were established HNC tissue characterized using immunohistochemistry DNA sequencing. Organoids exposed to chemo- radiotherapy panel of targeted agents. Organoid response was correlated with clinical response. CRISPR-Cas9-based gene...
IntroductionThe presence of previously unnoticed bilateral macroscopic salivary gland locations in the human nasopharynx was suspected after visualization by positron emission tomography/computed tomography with prostate-specific membrane antigen ligands (PSMA PET/CT). We aimed to elucidate characteristics this unknown entity and its potential clinical implications for radiotherapy.Materials methodsThe configuration PSMA-positive area evaluated a retrospective cohort consecutively scanned...
During posttreatment surveillance of head and neck cancer patients, imaging is insufficiently accurate for the early detection relapsing disease. Free circulating tumor DNA (ctDNA) may serve as a novel biomarker monitoring burden during these patients. In this exploratory study, we investigated whether low level ctDNA in plasma patients can be detected using Droplet Digital PCR (ddPCR).TP53 mutations were determined surgically resected primary samples from six with high stage (II-IV),...
Abstract Background Salivary duct carcinoma, an aggressive subtype of salivary gland cancer, is mostly androgen receptor‐positive. Only limited data are available on deprivation therapy (ADT). Methods Patients with advanced receptor‐positive carcinoma treated first‐line ADT were retrospectively evaluated for clinical benefit (ie, partial response [PR] and stable disease, progression‐free survival [PFS] overall [OS]). The OS was compared patients who received best supportive care. Results...
Salivary duct carcinoma (SDC) is a subtype of salivary gland cancer with dismal prognosis and need for better prognostication novel treatments. The aim this national cohort study was to investigate clinical outcome, prognostic factors, androgen receptor (AR) human epidermal growth factor 2 (HER2) expression. SDC patients diagnosed between 1990 2014 were identified by the Nationwide Network Registry Histo- Cytopathology in Netherlands (PALGA). Subsequently, medical records evaluated...
FGFR1 is a promising therapeutic target in multiple types of solid tumors, including head and neck squamous cell carcinoma (HNSCC). FGFR inhibitors have shown great value preclinical models. However, resistance remains major setback. In this study, we investigated the prognostic expression HNSCC, relevance targeting with AZD4547, potential resistant mechanisms.IHC FISH were applied on tissue microarrays to investigate protein gene copy numbers 452 HNSCCs. The sensitivity HNSCC lines either...
Current assessment of lymph node metastasis in patients with head and neck squamous cell carcinoma is not accurate enough to prevent overtreatment. The aim this study was validation a gene expression signature for distinguishing metastasizing (N+) from nonmetastasizing (N0) the oral cavity (OSCC) oropharynx (OPSCC) large multicenter cohort, using diagnostic DNA microarray Clinical Laboratory Improvement Amendments/International Organization Standardization-approved laboratory.A multigene...
Background and Objectives Evaluation of mandibular reconstructions with free fibula flaps. Identification factors associated major recipient site complications, that is, necessitating surgical intervention under general anaesthesia. Methods Seventy‐nine were included. The following analyzed: fixation type, number osteotomies, defect (bilateral/unilateral), surgeon, sex, ASA classification, continuous smoking, pathological N‐stage, age, size, flap ischemic time, postoperative radiotherapy....
Fibula free flaps (FFF) are effective in accomplishing successful reconstruction for segmental defects of the mandible. Potential risk factors FFF complications have been described previous research, e.g. age, comorbidity and smoking. Low skeletal muscle mass (SMM) has shown to be an emerging predictive factor prognostic survival head neck cancer. This study aims identify value low SMM surgical related complications, postoperative patients who underwent mandibular with after oral cavity...
Abstract Background There is an ongoing debate about the value of (neo‐)adjuvant chemotherapy in high‐ and intermediate‐grade osteosarcoma head neck. Methods All records patients older than 16 years diagnosed with neck Netherlands between 1993 2013 were reviewed. Results We identified a total 77 neck; 5‐year overall survival (OS) was 55%. In 50 surgically resected or younger 75 years, univariate multivariable analysis, adjusting for age resection margins, showed that who had not received...
Adenoid cystic carcinoma (AdCC) of the head and neck is an uncommon malignant epithelial tumour secretory glands. Many patients develop slowly growing local recurrence and/or distant metastasis, for which treatment options are limited. A retrospective analysis 9 AdCC was conducted to analyse visualization on PSMA PET/CT investigate expression primary, recurrent metastatic tissue using immunohistochemistry. Local occurred in six eight developed metastasis. All PET/CTs depicted PSMA-ligand...
Complete resection of tongue cancer is necessary to achieve local control. Unfortunately, deep margins are frequently inadequate. To improve margin control, accurate knowledge tumour thickness pivotal. Magnetic resonance imaging (MRI) and intraoral ultrasound (ioUS) applied for staging. This study explores the accuracy these techniques estimate depth invasion.The data patients with a T1-2 that had been treated surgically between 2014 2018 were retrospectively analysed. Measurements taken by...
Surgical removal of squamous cell carcinoma the tongue (SCCT) with tumour-free margin status (≥5 mm) is essential for loco-regional control. Inadequate margins (<5 often indicate adjuvant treatment, which results in increased morbidity. Ultrasound (US)-guided SCCT resection may be a useful technique to achieve more adequate compared conventional surgery. This study evaluates application and accuracy this technique.Forty patients were included consecutive US cohort. During surgery, surgeon...
Abstract Current conventional treatment modalities in head and neck squamous cell carcinoma ( HNSCC ) are nonselective have shown to cause serious side effects. Unraveling the molecular profiles of cancer may enable promising clinical applications that pave road for personalized treatment. We examined copy number status 36 common oncogenes tumor suppressor genes a cohort 191 oropharyngeal carcinomas OPSCC 164 oral cavity OSCC using multiplex ligation probe amplification. Copy was correlated...