A5020079950- Aortic aneurysm repair treatments
- Vascular Procedures and Complications
- Peripheral Artery Disease Management
- Aortic Disease and Treatment Approaches
- Sulfur Compounds in Biology
- Cardiac, Anesthesia and Surgical Outcomes
- Infectious Aortic and Vascular Conditions
- Central Venous Catheters and Hemodialysis
- Vascular anomalies and interventions
- Renal and Vascular Pathologies
- Coronary Interventions and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Abdominal vascular conditions and treatments
- Nitric Oxide and Endothelin Effects
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Diagnosis and Treatment of Venous Diseases
- Connexins and lens biology
- Venous Thromboembolism Diagnosis and Management
- Liver Disease and Transplantation
- Muscle and Compartmental Disorders
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Valve Diseases and Treatments
- Advanced X-ray and CT Imaging
- Diabetic Foot Ulcer Assessment and Management
University of Lausanne
2015-2025
ETH Zurich
2025
University of Zurich
2023-2025
Hôpital Orthopédique de la Suisse Romande
2006-2024
University Hospital of Lausanne
2014-2024
Clinique de La Source
2019
Institut et Haute Ecole de la Santé La Source
2019
University Hospital of Bern
2019
Gesellschaft für Klinische Forschung
2019
University of Geneva
2013
Although gut and lymph node (LN) memory CD4 T cells represent major HIV simian immunodeficiency virus (SIV) tissue reservoirs, the study of role dendritic (DCs) in persistence has long been limited to blood due difficulties access lymphoid samples. In this study, we show that LN migratory resident DC subpopulations harbor distinct phenotypic transcriptomic profiles. Interestingly, both contain intact provirus inducible replication-competent despite expression antiviral restriction factor...
Intimal hyperplasia (IH) remains a major limitation in the long-term success of any type revascularisation. IH is due to vascular smooth muscle cell (VSMC) dedifferentiation, proliferation and migration. The gasotransmitter Hydrogen Sulfide (H2S), mainly produced blood vessels by enzyme cystathionine- γ-lyase (CSE), inhibits pre-clinical models. However, there currently no H2S donor available treat patients. Here we used sodium thiosulfate (STS), clinically-approved source sulfur, limit...
Multiplexed imaging is increasingly used to study tissue architecture in health and disease. To investigate the cancer tumor microenvironment, typically either micro-arrays or small patient cohorts are collect process data. However, studies performed over course of years, collecting data from thousands samples rare require specialized workflows ensure sample throughput reproducibility for production processing. Here, we present two such multiplexed immunofluorescence mass cytometry tissues...
413 Background: Effective prostate cancer (PCa) risk stratification is paramount to guide treatment considerations across all stages of PCa. Serum PSA, Gleason score (GS), and bulk-profiling tests (e.g. Decipher) form the cornerstone in clinical practice. New techniques such as Imaging Mass Cytometry (IMC) now enable tumor profiling with unprecedented resolution. We developed a novel IMC assay goal identifying single cell subtypes prognostic outcomes localized Methods: Spatial single-cell...
For over 50 years, radiocephalic wrist arteriovenous fistulae (RCAVF) have been the primary and best vascular access for haemodialysis. Nevertheless, early failure due to thrombosis or non-maturation is a major complication resulting in their abandonment. This prospective study was designed investigate predictive value of intra-operative blood flow on RCAVF before first effective dialysis.We enrolled patients undergoing creation haemodialysis based pre-operative ultrasound mapping discussed...
To investigate the outcomes of patients who were treated for thoracoabdominal aortic aneurysms (TAAAs) using custom-made fenestrated-branched stent-grafts.A consecutive series 108 (mean age 73.5 years; 73 men) with TAAA E-xtra Design Engineering customized stent-grafts between November 2011 and January 2017. Data on baseline characteristics, procedures, clinical follow-up collected from 6 regional European surgical centers retrospective analysis endoleaks, reinterventions, target vessel...
Intimal hyperplasia (IH) is an abnormal response to vessel injury characterized by the dedifferentiation, migration, and proliferation of quiescent vascular smooth muscle cells (VSMC) form a neointima layer. Vascular connexins (Cx) are involved in pathophysiology various diseases, Cx43, main Cx expressed VSMC, has been shown promote VSMC IH. The aim this study was investigate participation another Cx, namely Cx37, formation layer.Wild-type (WT) Cx37-deficient (Cx37-/-) C57BL/6J mice were...
Intimal hyperplasia (IH) is the major cause of stenosis vein grafts. Drugs such as statins prevent stenosis, but their systemic administration has limited effects. We developed a hyaluronic acid hydrogel matrix, which ensures controlled release atorvastatin (ATV) at site injury. The kinetics demonstrated that 100% ATV was released over 10 hours, independent loading concentration hydrogel. investigated effects delivery on primary vascular smooth muscle cells isolated from human veins....
The ideal preservation temperature for donation after circulatory death kidney grafts is unknown. We investigated whether subnormothermic (22 °C) ex vivo machine perfusion could improve metabolism and reduce ischemia-reperfusion injury.To mimic procurement, kidneys from 45-kg pigs underwent 60 min of warm ischemia. Kidneys were then perfused 4 h with Belzer solution UW at 22 °C or before transplantation. Magnetic resonance spectroscopic imaging coupled LCModel fitting was used to assess...