A5007816984- Organ Transplantation Techniques and Outcomes
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Renal Transplantation Outcomes and Treatments
- Renal and Vascular Pathologies
- Sulfur Compounds in Biology
- Advanced Neuroimaging Techniques and Applications
- Medical Image Segmentation Techniques
- Metabolomics and Mass Spectrometry Studies
- Human Pose and Action Recognition
- MRI in cancer diagnosis
- Human Motion and Animation
- Seismic Imaging and Inversion Techniques
- Medical Imaging and Analysis
- Advanced Vision and Imaging
- Video Analysis and Summarization
- Electrical and Bioimpedance Tomography
- Sparse and Compressive Sensing Techniques
- Multimedia Communication and Technology
- Functional Brain Connectivity Studies
University of Geneva
2020-2024
Centre d'Imagerie BioMedicale
2022-2024
Laboratoire d'Informatique de Paris-Nord
2023-2024
Laboratoire d’Imagerie Biomédicale
2023-2024
The ideal preservation temperature for donation after circulatory death kidney grafts is unknown. We investigated whether subnormothermic (22 °C) ex vivo machine perfusion could improve metabolism and reduce ischemia-reperfusion injury.To mimic procurement, kidneys from 45-kg pigs underwent 60 min of warm ischemia. Kidneys were then perfused 4 h with Belzer solution UW at 22 °C or before transplantation. Magnetic resonance spectroscopic imaging coupled LCModel fitting was used to assess...
Background. The lack of organs for kidney transplantation is a growing concern. Expansion in organ supply has been proposed through the use after circulatory death (donation [DCD]). However, many DCD grafts are discarded because long warm ischemia times, and absence reliable measure viability. 31 P magnetic resonance imaging (pMRI) spectroscopy noninvasive method to detect high-energy phosphate metabolites, such as ATP. Thus, pMRI could predict energy state, its viability before...
MRI, a widespread non-invasive medical imaging modality, is highly sensitive to patient motion. Despite many attempts over the years, motion correction remains difficult problem and there no general method applicable all situations. We propose retrospective for estimation tackle of in-plane rigid-body motion, apt classical 2D Spin-Echo scans brain, which are regularly used in clinical practice. Due sequential acquisition k-space, artifacts well localized. The leverages power deep neural...
In rodents, hydrogen sulfide (H2S) reduces ischemia-reperfusion injury and improves renal graft function after transplantation. Here, we hypothesized that the benefits of H2S are conserved in pigs, a more clinically relevant model.Adult porcine kidneys retrieved immediately or 60 min warm ischemia (WI) were exposed to 100 µM sodium hydrosulfide (NaHS) (1) during hypothermic ex vivo perfusion only, (2) WI (3) both perfusion. Kidney was evaluated with dynamic contrast-enhanced MRI. MRI...
We have introduced an artificial intelligence framework, 31P-SPAWNN, in order to fully analyze phosphorus-31 (
Motivation: Motion correction in MRI predominantly relies on image-based methods and continues to be a challenge. Innovative approaches could harness better motion information latent k-space (i.e., the measurement space). Goal(s): Developing reference-less pipeline using deep learning. Approach: Our combines learning for parameter estimation with model-based image reconstruction. Large datasets were generated through physics-based simulations 2D brain acquisitions enhance model training...
Abstract Objectives Phosphorus-31 magnetic resonance spectroscopic imaging ( 31 P-MRSI) is a non-invasive tool for assessing cellular high-energy metabolism in-vivo. However, its acquisition suffers from low sensitivity, which necessitates large voxel sizes or multiple averages to achieve an acceptable signal-to-noise ratio (SNR), resulting in long scan times. Materials and methods To overcome these limitations, we propose reconstruction scheme FID-MRSI sequences. Specifically, employed...
Abstract Objective Expansion in organ supply has been proposed through the use of organs after circulatory death (donation [DCD]) order to face chronic shortage kidneys for transplantation. However, many DCD grafts are discarded because long warm ischemia times, and absence reliable non-invasive means determine kidney viability. P magnetic resonance imaging (pMRI) spectroscopy is a noninvasive method detect high-energy phosphate metabolites, such as ATP. reliability pMRI predict energy...
Abstract Objective Organ donation after circulatory death [DCD] has the potential to reduce shortage of kidneys available for transplantation. However, many DCD grafts are discarded because long warm ischemia times. Strategies reducing oxygen demand may minimize damages caused by ischemia/reperfusion injury. Ex-vivo, Hydrogen sulfide (H2S) reduces and ATP consumption isolated perfused kidney, inflammation improves renal function following reperfusion injury in rodents. benefits applicability...
Improved preservation strategies for the storage of graft collected after circulatory death could increase number kidneys available and improve patient survival. Warm (22 37°C) ex-vivo perfusion has emerged as a feasible strategy organ recovery, but underlying mechanism remains elusive. Using phosphorus magnetic resonance spectroscopic imaging ( 31 P-MRSI) histological scoring, we evaluated kidney viability adenosine triphosphate (ATP) production during sub-normothermic (SNOP) versus...
In the age of artificial intelligence, there is a need for simple and inexpensive frameworks aimed at performing standardized reproducible motion-controlled experiments allowing creation datasets motion corrupted in vivo MRI scans. Focused on human brain imaging, we propose ChoCo: choreography controlled protocol head an ad-hoc hardware device synchronization between scanner movie displaying to be performed. A proof concept demonstrated that 6 participants were able reproduce choreographies...
In the context of EPI time series acquisition, fast motion occurring below Nyquist limit (< 1 TR), present a problem for accurate registration by 3D rigid-body algorithms. A method temporally upsampling SMS acquisitions is proposed. volumes are splitted into subvolumes according to temporal acquisition order and interpolated using data driven approach based on pairwise affine transforms linear interpolation. proof concept controlled head choreographies shows that rate can be more...
MRI, a widespread non-invasive medical imaging modality, is highly sensitive to patient motion. Despite many attempts over the years, motion correction remains difficult problem and there no general method applicable all situations. We propose retrospective for estimation tackle of in-plane rigid-body motion, apt classical 2D Spin-Echo scans brain, which are regularly used in clinical practice. Due sequential acquisition k-space, artifacts well localized. The leverages power deep neural...