A5025258298- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Intensive Care Unit Cognitive Disorders
- Intracranial Aneurysms: Treatment and Complications
- Neurosurgical Procedures and Complications
- Cerebrospinal fluid and hydrocephalus
- Healthcare Decision-Making and Restraints
- Cerebrovascular and Carotid Artery Diseases
- Family and Patient Care in Intensive Care Units
- Opioid Use Disorder Treatment
- Atrial Fibrillation Management and Outcomes
- Dementia and Cognitive Impairment Research
- Vascular Malformations Diagnosis and Treatment
- Protease and Inhibitor Mechanisms
- Blood Coagulation and Thrombosis Mechanisms
- Chemotherapy-induced cardiotoxicity and mitigation
- Subtitles and Audiovisual Media
- MRI in cancer diagnosis
- Infectious Encephalopathies and Encephalitis
- Cardiac, Anesthesia and Surgical Outcomes
- Migraine and Headache Studies
- Vascular Procedures and Complications
- Infant Development and Preterm Care
- Cardiac electrophysiology and arrhythmias
Rhode Island Hospital
2019-2025
Providence College
2019-2025
University of Nottingham
2025
Novartis (United States)
2024
Arcadia
2024
MGH Institute of Health Professions
2022-2024
Brown University
2019-2023
Massachusetts General Hospital
2022
Neurology, Inc
2022
Faxton St. Luke's Healthcare
2021
Background Standardised Diagnostic Assessment tools, such as the Development and Well‐Being (DAWBA), may aid detection diagnosis of emotional disorders but there is limited real‐world evidence their clinical or cost effectiveness. Methods We conducted a multicentre, two‐arm parallel group randomised controlled trial in eight large National Health Service Trusts England providing multidisciplinary specialist Child Adolescent Mental Services (CAMHS). Participants (5–17 year‐olds with...
Poststroke delirium may be underdiagnosed due to the challenges of disentangling symptoms from underlying neurologic deficits. We aimed determine prevalence individual features and frequency with which they could not assessed in patients intracerebral hemorrhage. Prospective observational cohort study. Neurocritical Care Stroke Units at a university hospital. Consecutive hemorrhage February 2018 May 2018. None. An attending neurointensivist performed 257 total daily assessments for on 60...
Susceptible adults (n = 105) were enrolled into a randomized double-blind study of rimantadine treatment experimental influenza A infection. Subjects cloistered for 8 days and challenged with rimantadine-sensitive strain H1N1 virus at the end first day. Fortyeight hours after challenge days, 54 subjects received placebo 51 (100 mg orally, twice day). Symptoms, signs, pathophysiologies monitored. Nine not infected. Seventeen (38%) in 26 (53%) group became ill. beneficial effect was documented...
To determine the impact of delirium on withdrawal life-sustaining treatment (WLST) after intracerebral hemorrhage (ICH) in context established predictors poor outcome, using data from an institutional ICH registry.We performed a single-center cohort study consecutive patients with admitted over 12 months. features were prospectively adjudicated, and WLST corresponding hospital day recorded retrospectively. Patients categorized DSM-5 criteria as never delirious, ever delirious (either...
Delirium is associated with worse outcomes in patients stroke and neurocritical illness, but delirium detection these can be challenging existing screening tools. To address this gap, we aimed to develop evaluate machine learning models that detect episodes of post-stroke based on data from wearable activity monitors conjunction stroke-related clinical features. Prospective observational cohort study. Neurocritical Care Stroke Units at an academic medical center. We recruited 39...
Clinical fluctuations in ischemic stroke symptoms are common, but before hospital arrival have not been previously characterized.A standardized qualitative assessment of was obtained an observational study that enrolled patients with mild (National Institutes Health Stroke Scale [NIHSS] score 0-5) present on to within 4.5 hours onset, a subset 100 hospitals participating the Get With The Guidelines-Stroke quality improvement program. number fluctuations, direction, and overall or worsening...
Background: Cisternal score (CISCO), which is calculated based on quantification of blood clot in basal cisterns, has been shown to have good accuracy predicting ventriculoperitoneal shunt requirement patients with aneurysmal subarachnoid hemorrhage (aSAH). We hypothesized that CISCO superior modified Fisher (mFS) vasospasm, a common complication associated worse outcomes aSAH, as it better quantifies burden the cisterns. Design/Methods: performed post hoc analysis retrospective study cohort...
NCT03114319 is an ongoing open-label phase I dose escalation/expansion trial of TN, allosteric inhibitor SHP2, in combination with the anti-PD-1 antibody, SPA, or CDK4/6 RIB adults advanced solid tumors. Eligible patients (pts) were treated either A) TN (5-50 mg BID, 20 60 QD) on a 2 weeks on/1 week off (2w/1w) schedule SPA 300 once every 3 (Q3W) B) (20-60 QD, 20-40 BID), 2w/1w 3w/1w (150-200 continuously, 2w/1w, (excludes data from Japan-specific escalation). A Bayesian hierarchical model...
We hypothesized that CISCO is superior to modified Fisher score (mFS) in predicting vasospasm, as it better quantifies blood clot burden the basal cisterns.
Nonaneurysmal perimesencephalic subarachnoid hemorrhage (pmSAH) is considered to have a lower-risk pattern than other types of (SAH). However, minority patients with pmSAH may harbor causative posterior circulation aneurysm. To exclude this possibility, many institutions pursue exhaustive imaging. In study the authors aimed develop novel predictive model based on initial noncontrast head CT (NCHCT) features differentiate from aneurysmal causes. The retrospectively reviewed admitted an...
Spontaneous angiogram-negative nonperimesencephalic subarachnoid hemorrhage (an-NPSAH) can represent a diagnostic and management dilemma. The authors sought to determine radiographic predictors of aneurysmal etiology based on admission noncontrast head CT scans. performed retrospective cohort study prospectively collected data from consecutive patients who were admitted for spontaneous (SAH) with suspected an academic center 2016 2021. They compared blood thickness in the basal cisterns...
We report a retrospective study of 59 patients for whom our university hospital nursing service had required the use lay sitters because need constant observation. Of 54 charts examined, 28 noted psychiatric consultation, mostly delirious states. Quality care deficits discerned included (1) inadequate pharmacotherapy alcoholic and nonalcoholic delirium, (2) search treatable causes delirium (thyroid, B12, folate deficiencies), (3) insufficient awareness persistent cognitive deficits, which...
Introduction: Post-stroke delirium is associated with worse outcomes, yet likely underdiagnosed due to the challenges of disentangling symptoms from underlying neurological deficits. We aimed determine prevalence individual features and frequency which they could not be assessed in a cohort patients intracerebral hemorrhage (ICH). Methods: Consecutive admitted ICH received daily assessments for by an expert clinician, all included Confusion Assessment Method ICU (CAM-ICU), Intensive Care...
Background: Headache and neck pain are common in patients with aneurysmal subarachnoid hemorrhage (aSAH) throughout their course. Because is often a sequela, these at risk for opioid dependence. Long term use has not been well studied this population. Methods: We analyzed cohort of consecutive who were admitted diagnosis aSAH to an academic referral center from 2015 2018. excluded died during hospitalization or discharged hospice previously taking any opioids. The following variables...