A5025978175- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Virus-based gene therapy research
- Monoclonal and Polyclonal Antibodies Research
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cutaneous lymphoproliferative disorders research
- Cervical Cancer and HPV Research
- CAR-T cell therapy research
- Nanoplatforms for cancer theranostics
- Inflammatory Biomarkers in Disease Prognosis
- Lymphoma Diagnosis and Treatment
- Cancer Research and Treatments
- Medical Imaging Techniques and Applications
- Cancer Genomics and Diagnostics
- Viral Infectious Diseases and Gene Expression in Insects
- Radiopharmaceutical Chemistry and Applications
- Glycosylation and Glycoproteins Research
- Epigenetics and DNA Methylation
- Veterinary Oncology Research
- Hernia repair and management
- Adenosine and Purinergic Signaling
- Advanced biosensing and bioanalysis techniques
- Fungal Infections and Studies
The Barbara Ann Karmanos Cancer Institute
2015-2025
Wayne State University
2016-2025
The University of Texas MD Anderson Cancer Center
2020-2023
Henry Ford Hospital
2005-2023
Cancer Research Center
2022
The University of Texas Health Science Center at Houston
2020
The Ohio State University
2011-2015
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2015
Detroit R&D (United States)
2015
The Ohio State University Wexner Medical Center
2013
Linearly sloped or ``ramp'' potentials belong to a class of core-softened models which possess liquid-liquid critical point (LLCP) in addition the usual liquid-gas point. Furthermore, they exhibit thermodynamic anomalies their density and compressibility, nature may be akin those occurring water. Previous simulation studies ramp have focused on just one functional form, for LLCP is thermodynamically stable. In this work we construct series potentials, interpolate between previously studied...
CTLA-4 is a member of the costimulatory family, has homology to CD28, and binds B7 family ligands. Unlike ligation transmits negative signal in T cells. expression, while inducible most cells, expressed constitutively on cells with regulatory phenotype. The mechanism controlling expression human poorly characterized, thus we sought better understand activation gene. By cloning 5' upstream promoter creating promoter-deletion reporter constructs, show that proximal critical for activating...
Mycosis fungoides (MF) is a cutaneous T-cell lymphoma (CTCL) characterized by neoplastic skin-homing T cells. To better understand the immunopathogenesis of MF, we analyzed functional ability peripheral blood mononuclear cells (PBMC) from early and late MF/CTCL patients to express cytokine genes. In stage MF/CTCL, were separated into those with involvement (+B) without (-B).We T(H)1 (interleukin 2 (IL-2), IFN-gamma), T(H)2 (IL-4, IL-5, IL-10, IL-13), T(H)17 (IL-17) gene expression activated...
Abstract IFNγ is an attractive target for imaging active antitumor immunity due to its function in the T-cell signaling axis. Here, we test immuno-PET (immunoPET) probe capacity identify adaptive immunotherapy response after HER2/neu vaccination both spontaneous salivary and orthotopic neu+ mouse mammary tumors. immunoPET detected elevated cytokine levels situ vaccination, which inversely correlated with tumor growth rate, indicator of therapy. In a model induced anergy where CD8 T cells...
Dysregulated cathepsin activity is linked to various human diseases including metabolic disorders, autoimmune conditions, and cancer. Given the overexpression of in tumor microenvironment, inhibitors are promising pharmacological agents drug delivery vehicles for cancer treatment. In this study, we describe synthesis photochemical biological assessment a dual-action agent based on ruthenium that conjugated with inhibitor, designed both photodynamic therapy (PDT) photochemotherapy (PCT). The...
Abstract Background Addressing critical gaps in precision medicine initiatives colorectal cancer (CRC) requires building larger collaborative studies. Methods The Latino Colorectal Cancer Consortium (LC3) is a resource that harmonizes data collected observational studies with from individuals who identify as Hispanic/Latino diagnosis of primary adenocarcinoma. Data includes demographics, medical history, family and lifestyle risk factors patient-completed surveys. Vital status, cause death,...
Tumor associated macrophages (TAMs) suppress the cancer immune response and are a key target for immunotherapy. The effects of ruthenium rhodium complexes on TAMs have not been well characterized. To address this gap in field, panel 22 dirhodium were screened against three subtypes macrophages, triple-negative breast normal tissue cells. Experiments carried out 2D biomimetic 3D co-culture experiments with without irradiation blue light. Leads identified cell-type-specific toxicity toward...
Abstract Aberrant expression of the Forkhead box transcription factor, FOXQ1, is a prevalent mechanism epithelial-mesenchymal transition (EMT) and metastasis in multiple carcinoma types. However, it remains unknown how FOXQ1 regulates gene expression. Here, we report that initiates EMT by recruiting MLL/KMT2 histone methyltransferase complex as transcriptional coactivator. We first establish promoter recognition precedes MLL assembly histone-3 lysine-4 trimethylation within regions critical...
Immune checkpoint inhibitors (ICI) have improved outcomes for a variety of malignancies; however, many patients fail to benefit. While tumor-intrinsic mechanisms are likely involved in therapy resistance, it is unclear what extent host genetic background influences response. To investigate this, we utilized the Diversity Outbred (DO) and Collaborative Cross (CC) mouse models. DO mice an outbred stock generated by crossbreeding eight inbred founder strains, CC recombinant from same founders....
Neutralizing antibodies (nAB) at the time of administration hamper effectiveness adeno-associated virus (AAV) as a clinical DNA delivery system. The present study was designed to investigate if AAV re-administration in muscle tissue is dependent on nAB titer. Recombinant (r)AAV serotype 1, promising candidate for targeting skeletal muscle, used gene delivery. C57Bl/6 mice were infected intramuscularly with doses between 1 x 10(9) and 5 10(10) particles (vp) AAV1-expressing luciferase...
Layer-by-layer (LbL) films containing cationic polyelectrolytes and anionic bioactive molecules such as DNA are promising biomaterials for controlled localized gene delivery a number of biomedical applications including cancer vaccine delivery. Bioreducible LbL made disulfide-containing poly(amido amine)s (PAAs) plasmid can be degraded by redox-active membrane proteins through the thiol–disulfide exchange reaction to release exclusively into extracellular microenvironment adjacent film. In...
Abstract Novel therapies are urgently needed for epithelial ovarian cancer (EOC), the most lethal gynecologic malignancy. In addition, that target unique vulnerabilities in tumor microenvironment (TME) of EOC have largely been unrealized. One strategy to achieve selective drug delivery therapy involves use targeted antifolates via their uptake by folate receptor (FR) proteins, resulting inhibition essential one-carbon (C1) metabolic pathways. FRα is highly expressed EOCs, along with...
The Collaborative Cross (CC) and the Diversity Outbred (DO) stock mouse panels are most powerful murine genetics tools available to community. Together, they combine strength of inbred animal models with diversity outbred populations. Using 63 CC strains or a panel DO mice, each derived from same 8 parental strains, researchers can map genetic contributions exceptionally complex immunological infectious disease traits that would require far greater powering if performed by genome-wide...
Abstract— Analytical scanning electron microscopy has been used to investigate the surface textures and compositions of newly exposed shatter cones from 1.85 Ga Sudbury impact structure, Canada. Unusual microstructures are observed at micron scale, including silicate melt smears, fibres splats. Silicate Ni‐rich spherules up 5 μm in diameter adorn earlier‐formed features, we interpret these be condensates formed due shock‐induced vaporization cone surfaces. The development striations on is...
Abstract Percutaneous cryoablation is a minimally invasive procedure for tumor destruction, which can potentially initiate or amplify antitumor immunity through the release of tumor-associated antigens. However, clinically efficacious lacking and regional recurrences are limiting factor relative to surgical excision. To understand mechanism immune activation by cryoablation, comprehensive analyses innate HER2/neu humoral cellular following with without peritumoral CpG injection were...
Abstract TNF‐related apoptosis‐inducing ligand receptor 2 [TRAIL‐R2 or death 5 (DR5)] is expressed at elevated levels in a broad range of solid tumors to mediate apoptotic signals from TRAIL agonist antibodies. We tested the hypothesis that DR5 DNA vaccination will induce proapoptotic antibody trigger apoptosis tumor cells. BALB/c mice were electrovaccinated with DNA‐encoding wild‐type human (ph ) its derivatives. Resulting immune serum purified IgG induced triple‐negative breast cancer...