A5028694622- Inflammatory Bowel Disease
- Diverticular Disease and Complications
- Autoimmune and Inflammatory Disorders
- Genetic factors in colorectal cancer
- Gastrointestinal disorders and treatments
- Colorectal Cancer Treatments and Studies
- Mesenchymal stem cell research
- Colorectal Cancer Surgical Treatments
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Microscopic Colitis
- Chronic Lymphocytic Leukemia Research
- Tissue Engineering and Regenerative Medicine
- Neurogenesis and neuroplasticity mechanisms
- Gastric Cancer Management and Outcomes
- Liver Diseases and Immunity
- Pancreatic and Hepatic Oncology Research
- Lipid metabolism and biosynthesis
- Extracellular vesicles in disease
- Anorectal Disease Treatments and Outcomes
- Stoma care and complications
Cleveland Clinic
2019-2025
Weill Cornell Medicine
2017-2022
Cornell University
2016-2022
Presbyterian Hospital
2016-2018
New York Hospital Queens
2016-2017
NewYork–Presbyterian Hospital
2016-2017
Rutgers, The State University of New Jersey
2007-2014
Johnson University
2013
University Hospital, Newark
2009
Rutgers New Jersey Medical School
2007-2009
It is well established that BDNF may enhance oligodendrocyte differentiation following a demyelinating lesion, however, the endogenous sources of be harnessed to reverse deficits associated with such lesions are poorly defined. Here, we investigate roles astrocytes in synthesizing and releasing BDNF. These cells known express injury <i>in vivo</i>. In culture, they increase synthesis release response glutamate metabotropic stimulation. Following cuprizone-elicited demyelination mice, contain...
Solid abdominal organ transplantation is fraught with variable rates of rejection and graft versus host disease. We sought to determine the safety efficacy an advanced extracellular vesicle (EV) investigational product (IP) derived from mesenchymal stem cells (MSC) in transplant patient population. Seven separate eINDs were filed FDA for emergency treatment isolated intestinal (n=2), liver allograft modified multivisceral (n=3), GVHD patients (n=2). 15 mL IP was administered intravenously on...
Previously we demonstrated that insulin-like growth factor-I mediates the sustained phosphorylation of Akt, which is essential for long term survival and protection glial progenitors from glutamate toxicity. These prosurvival effects correlated with prolonged activation stability factor type-I receptor. In present study, investigated mechanisms whereby signaling, through receptor, Akt. We showed stimulation induced loss receptors cell surface but recovered over time. Blocking receptor...
Advanced non-alcoholic fatty liver disease (NAFLD) is a rapidly emerging global health problem associated with pre-disposing genetic polymorphisms, most strikingly an isoleucine to methionine substitution in patatin-like phospholipase domain-containing protein 3 (PNPLA3-I148M). Here, we study how human hepatocytes PNPLA3 148I and 148M variants engrafted the livers of broadly immunodeficient chimeric mice respond hypercaloric diets. As early as four weeks, developed dyslipidemia, impaired...
Abstract Background Traditionally, perianal skin tag excision has been contraindicated in patients with Crohn’s disease (CD) owing to risk of non-healing wounds. However, little data exists on this topic. We aimed review our institutional experience outcomes after CD. hypothesized that CD would be associated Methods retrospectively reviewed adults who underwent or without limited excisional hemorrhoidectomy at center between 2012 and 2024. Demographics, characteristics, medications,...
Abstract Traditionally, perianal skin tag excision has been contraindicated in patients with Crohn’s disease (CD) owing to risk of non-healing wounds. However, little data exists on this topic. We aimed review our institutional experience outcomes after CD. hypothesized that CD would be associated retrospectively reviewed adults who underwent or without limited excisional hemorrhoidectomy at center between 2012 and 2024. Demographics, characteristics, medications, operative data, pathology,...
Abstract Background Addressing critical gaps in precision medicine initiatives colorectal cancer (CRC) requires building larger collaborative studies. Methods The Latino Colorectal Cancer Consortium (LC3) is a resource that harmonizes data collected observational studies with from individuals who identify as Hispanic/Latino diagnosis of primary adenocarcinoma. Data includes demographics, medical history, family and lifestyle risk factors patient-completed surveys. Vital status, cause death,...
Abstract Ancestrally diverse and admixed populations, including the Hispanic/Latino/a/x/e community, are underrepresented in cancer genetic/genomic studies. Leveraging Latino Colorectal Cancer Consortium (LC3) other existing datasets, we analyzed whole exome sequencing data on tumor/normal pairs from 718 individuals with colorectal to map somatic mutational features by ethnicity genetic similarity. Global proportions of African, Asian, European, Native American ancestries were estimated...
There have been no studies into the direct injection of mesenchymal stem cells (MSCs) for luminal ulcerative colitis (UC). Our aim was to investigate efficacy MSCs delivered locally via endoscopic delivery, as is done in setting perianal disease, treat local site inflammation directly.A phase IB/IIA randomized control clinical trial remestemcel-L, an ex vivo expanded allogeneic bone marrow-derived MSC product, at a dose 150 million versus placebo (2:1 fashion) using 23-gauge sclerotherapy...
Abstract Previously we showed that insulin‐like growth factor‐I (IGF‐I) promotes sustained phosphorylation of Akt in oligodendrocyte progenitor cells (OPCs) and is required for survival these cells. The direct mechanisms, however, by which IGF‐I are currently undefined. Recently, cholesterol‐enriched membranes (CEMs) have been implicated regulation factor‐mediated activation the PI3K/Akt pathway mature oligodendrocytes; less know about their role OPC survival. In present study, investigate...
Data from previous studies suggest Crohn disease of the appendix accounts for ∼25% granulomatous appendicitis cases. However, we have found that inflammation in appendectomy specimens rarely heralds disease. We suspect appendiceal involvement by is uncommon, even when patients severe ileocolonic inflammation. performed this study to determine prevalence and nature among with reviewed 100 ileocolic strictures fistulizing distribution inflammatory changes compared them appendices on colectomy...
Epstein-Barr virus associated smooth muscle tumor (EBV-SMT) is a rare oncological entity. However, there an increasing incidence of EBV-SMTs, as the frequency organ transplantation and immunosuppression grows. EBV-SMT diagnosis relies on histopathology immunochemical staining to distinguish it from post-transplant lymphoproliferative disorder (PTLD). There no clear consensus treatment EBV-SMTs. surgical resection, chemotherapy, radiation therapy, reduction have been explored with varying...
Pyoderma gangrenosum (PG) is a debilitating skin condition often accompanied by inflammatory bowel disease (IBD). Strikingly, ~40% of patients that present with PG have underlying IBD, suggesting shared but unknown mechanisms pathogenesis. Impeding the development effective treatments for absence an animal model exhibits features both and gut manifestations. This study describes first experimental drug-induced mouse concomitant intestinal inflammation. Topical application pyrimidine...
ABSTRACT Enterocolic lymphocytic phlebitis is a rare vasculitis afflicting the gastrointestinal veins without involving arterial system. Lymphocytic colitis more common pathology described as inflammation of colonic epithelium. Concurrence both these pathologies extremely rare. We describe 53-year-old man presenting with chronic watery diarrhea, abdominal pain, and weight loss. Colonoscopic examination revealed normal-appearing mucosa, but biopsy findings coexisting enterocolic phlebitis....
Journal Article Remestemcel-L allogeneic bone marrow-derived mesenchymal stem cell product to treat medically refractory Crohn's colitis: preliminary phase IB/IIA study Get access Amy L Lightner, Lightner Department of Colorectal Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, Ohio, USA Correspondence to: 9500 Euclid Avenue, Cleveland, Ohio 44195, (e-mail: lightna@ccf.org) https://orcid.org/0000-0002-0459-0699 Search for other works by this author on: Oxford Academic...
Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is a sensitive and specific tool in the risk stratification of pancreatic lesions, including cysts. The sensitivity specificity EUS-FNA has been shown to improve when cytology combined with next-generation sequencing (NGS). Ideally, fresh cyst fluid used for NGS. In this pilot study, we explore possibility DNA derived from residual alcohol-fixed aspirates.