A5004007255- Cancer survivorship and care
- Childhood Cancer Survivors' Quality of Life
- Family Support in Illness
- Cancer-related cognitive impairment studies
- Palliative Care and End-of-Life Issues
- Sleep and related disorders
- COVID-19 and healthcare impacts
- Prostate Cancer Treatment and Research
- Economic and Financial Impacts of Cancer
- Patient-Provider Communication in Healthcare
- Radiopharmaceutical Chemistry and Applications
- Telemedicine and Telehealth Implementation
- COVID-19 and Mental Health
- Cancer Treatment and Pharmacology
- Circadian rhythm and melatonin
- Nutrition and Health in Aging
- Prostate Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Global Cancer Incidence and Screening
- Health Systems, Economic Evaluations, Quality of Life
- BRCA gene mutations in cancer
- CAR-T cell therapy research
- Head and Neck Cancer Studies
- Health and Wellbeing Research
- Bipolar Disorder and Treatment
Moffitt Cancer Center
2016-2025
Harvard University Press
2025
Pacific Northwest National Laboratory
2025
Valparaiso University
2024
University of South Florida
2010-2024
University of Valparaíso
2024
Centro Uruguayo de Imagenología Molecular
2024
Althaia
2023
Stanford University
2023
Comprehensive Blood & Cancer Center
2023
Over the last two decades, we have extensively studied genetics of congenital adrenal hyperplasia caused by 21-hydroxylase deficiency (CAH) and performed 8,290 DNA analyses CYP21A2 gene on members 4,857 families at risk for CAH—the largest cohort CAH patients reported to date. Of studied, 1,507 had least one member affected with three known forms CAH, namely salt wasting, simple virilizing, or nonclassical CAH. Here, report genotype phenotype each patient, as well ethnic group country origin...
Men receiving androgen-deprivation therapy (ADT) for prostate cancer may be at risk cognitive impairment; however, evidence is mixed in the existing literature. Our study examined impact of ADT on impaired performance and explored potential demographic genetic predictors performance.Patients with were assessed before or within 21 days starting (n = 58) 6 12 months later. Age- education-matched patients treated prostatectomy only 84) men without 88) similar intervals. Participants provided...
Patients with cancer typically have greater financial hardships and time costs than individuals without cancer. The COVID-19 pandemic has exacerbated this, while posing substantial challenges to delivering care resulting in important changes care-delivery models, including the rapid adoption of telehealth.To estimate patient travel, time, cost savings associated telehealth for delivery.An economic evaluation from completed visits April 1, 2020, June 30, 2021, a single-institution National...
Importance While the health care community advocates broadly for climate change policy, medical professionals can look within practices to assess their contribution carbon dioxide (CO 2 ) emissions, and provide solutions wherever possible. Telemedicine help in mitigating by providing from a distance. Objective To savings achieved telemedicine visits. Design, Setting, Participants This cross-sectional study of visits was conducted at single-institution National Cancer Institute...
Abstract Objective : Previous research has shown that lung cancer patients are at an increased risk for depressive symptomatology; however, little is known about the factors contributing to depression in these patients. This study focused on possible association between perceived stigma related a diagnosis and symptomatology. It was hypothesized greater would be symptomatology account variance above beyond accounted by relevant clinical, demographic, psychosocial variables. Method A sample...
Exposures to carcinogens in hair products have been explored as breast cancer risk factors, yielding equivocal findings. We examined product use (hair dyes, chemical relaxers and cholesterol or placenta-containing conditioners) among African American (AA) White women, associations with cancer. Multivariable-adjusted models were used estimate odds ratios (ORs) 95% confidence intervals (CIs) describe the of interest 2280 cases (1508 AA 772 White) 2005 controls (1290 715 White). Among controls,...
Abstract Background Behavioral digital health interventions (e.g., mobile apps, websites, wearables) have been applied widely to improve outcomes. However, many groups people with low income levels, who are geographically isolated, older adults) may face obstacles technology access and use. In addition, research has found that biases stereotypes can be embedded within interventions. As such, behavioral intend overall population unintentionally widen health-related inequities. Purpose This...
Androgen-deprivation therapy (ADT) is well established as the standard of care in metastatic prostate cancer (PCa) management; however, ADT has significant adverse effects (AEs) that must be addressed. This review aims to highlight opportunities mitigate AEs and explore alternatives PCa management. Specifically, we discuss behavioral pharmacologic strategies for mitigating ADT-sparing approaches hormone-sensitive castration-resistant PCa. Equipped with effective mitigation possible...
Insomnia is the most common sleep disorder in patients with epithelial ovarian cancer (EOC). We investigated causal association between genetically predicted insomnia and EOC risk survival through a two-sample Mendelian randomization (MR) study.
There is growing empirical and clinical interest in purported associations between smoking the aggravation of cancer symptoms treatment side effects, such as pain. Both pain are highly prevalent among persons with cancer, there recent evidence to suggest that patients who continue smoke despite their diagnosis experience greater than nonsmokers. Accordingly, main goal this cross-sectional study was examine multiple levels status several pain-related outcomes a sample 224 about begin...
BACKGROUND Patients with prostate cancer receiving androgen deprivation therapy (ADT) are at risk of sleep disturbance; however, to the authors' knowledge, mechanisms by which ADT may affect not well understood. The current study compared objective and subjective disturbance in recipients controls examined whether is attributable influence on hot flashes nocturia. METHODS were assessed before or within 1 month after initiation as 6 months 12 later (78 patients). treated prostatectomy only...
Rapid implementation of telehealth for cancer care during COVID-19 required innovative and adaptive solutions among oncology health providers professionals (HPPs).The aim this qualitative study was to explore HPPs' experiences with the pandemic.This conducted at Moffitt Cancer Center (Moffitt), an NCI (National Institute)-Designated Comprehensive Center. Prior COVID-19, piloted visits on a limited basis. After rapidly expanded visits. Telehealth included real-time videoconferencing between...
Chimeric antigen receptor (CAR) T-cell therapy can lead to durable responses in patients with relapsed/refractory hematologic malignancies. Immune effector cell-associated neurotoxicity syndrome (ICANS) and cytokine release (CRS) are common may place at risk for longer-term cognitive impairment. This study examined changes cognition the first year after CD19-directed CAR lymphoma, as well therapy-specific risk-factors (e.g., ICANS, CRS) nonspecific factors baseline quality of life, frailty)...
Background: Patients with cancer require timely access to care so that healthcare providers can prepare an optimal treatment plan significant implications for quality of life and mortality. The COVID-19 pandemic spurred rapid adoption telemedicine in oncology, but study patient experience this population has been limited. We assessed overall at NCI-designated Comprehensive Cancer Center during the examined changes over time. Methods: This was a retrospective outpatient oncology patients who...
Background National guidelines recommend germline genetic testing (GT) for all patients with early-onset colorectal cancer. With recent advances in targeted therapies and GT, these are expected to expand include broader groups of However, there is a shortage professionals provide the necessary education support informed consent. As such, pressing need identify alternative approaches facilitate expedite access GT. Objective This study describes development pretest intervention, Nest-CRC,...
Our institution launched a large-scale virtual training program called "Stepping Stones" that uses allegories to provide an increased understanding of concepts, such as interpersonal, internalized, and structural racism. The goal this project was implement facilitated discussions with trained leaders determine the impact these sessions in improving experience modules boosting comfort discussing race We developed complimentary intervention for colleagues who participated system-wide...
405 Background: While standard mpMRI has shown benefit in increasing detection of clinically significant prostate cancer, it is limited its ability to detect small lesions, low Gleason scores, and certain tumor architectures. Proteomics may supplement imaging enhance prediction clinical outcomes. We investigated associations between MRI-mapped tumors protein levels obtained from radical prostatectomy (RP) specimens correlated them adverse pathology features. Methods: This was an interim...