A5011645918- BRCA gene mutations in cancer
- Cancer Genomics and Diagnostics
- Bladder and Urothelial Cancer Treatments
- Genetic factors in colorectal cancer
- Service and Product Innovation
- Colorectal Cancer Screening and Detection
- Persona Design and Applications
- Mobile Health and mHealth Applications
- Genomic variations and chromosomal abnormalities
- Nutrition, Genetics, and Disease
- Pancreatic and Hepatic Oncology Research
- Palliative Care and End-of-Life Issues
- Patient-Provider Communication in Healthcare
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related Molecular Pathways
- Biomedical and Engineering Education
- Ovarian cancer diagnosis and treatment
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Treatments and Studies
- Digital Mental Health Interventions
- Cerebral Palsy and Movement Disorders
- Epigenetics and DNA Methylation
- Technology Use by Older Adults
- Muscle activation and electromyography studies
- Prenatal Screening and Diagnostics
Moffitt Cancer Center
2015-2025
Memorial Sloan Kettering Cancer Center
2021-2022
RWTH Aachen University
2018-2019
Virginia Commonwealth University
2015
University of Oklahoma Health Sciences Center
2012
Sobell House
1990
Background National guidelines recommend germline genetic testing (GT) for all patients with early-onset colorectal cancer. With recent advances in targeted therapies and GT, these are expected to expand include broader groups of However, there is a shortage professionals provide the necessary education support informed consent. As such, pressing need identify alternative approaches facilitate expedite access GT. Objective This study describes development pretest intervention, Nest-CRC,...
In many countries, including Germany, older people are increasing in numbers, while fewer caregivers available. A way to address the problem is develop new medical assistance and monitoring systems that operated by elderly on their own, e.g. in-home aftercare systems.The development of a set eight data-based personas terms best practice approach presented."Personas" an integral method user-centered design approach. They incomplete knowledge individual user behaviour introducing archetypal...
556 Background: Bladder cancer has one of the highest rates human epidermal growth factor receptor 2 (HER2) alteration. Novel HER2-directed agents are being investigated in metastatic BC. We sought to define incidence and clinical characteristics HER2-altered BC across disease states. Methods: retrospectively analyzed our single-institution, clinically annotated cohort urothelial pts with available genomic profiling data (MSK-IMPACT). quantified prevalence HER2 alterations, defined as driver...
CW is a Caucasian woman aged 70 years with history of asthma, sleep apnea (on continuous positive airway pressure), hypertension, and hyperlipidemia who presented to her primary care physician for annual physical. She was otherwise well specifically denied any gastrointestinal symptoms or unintentional weight loss. Per patient report review outside records, she underwent computed tomography (CT) scan the chest without contrast abnormal pulmonary physical examination findings. The CT revealed...
Abstract Introduction: Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related deaths in United States. National guidelines recommend germline genetic testing (GT) for all PDAC patients, but only 6.8-19% obtain GT. Current GT barriers include under-referral and counselor shortage. Our goal was to improve uptake among patients using a novel delivery model education testing. Methods: The Genetic Information Treatment Decisions (GIFTD) Initiative at Moffitt Cancer...
<sec> <title>BACKGROUND</title> National guidelines recommend germline genetic testing (GT) for all patients with early-onset colorectal cancer. With recent advances in targeted therapies and GT, these are expected to expand include broader groups of However, there is a shortage professionals provide the necessary education support informed consent. As such, pressing need identify alternative approaches facilitate expedite access GT. </sec> <title>OBJECTIVE</title> This study describes...
e12552 Background: Recently the ability to tailor therapies particular somatic mutations present in a patient’s tumor has grown significantly. However found may have implications if also germline. Through Moffitt’s Personalized Medicine Consult Service (PMCS), we sought find streamlined approach identify patients with testing whom referral Genetic Risk Assessment (GRAS) for consideration of germline would be appropriate. Methods: The GRAS provided PMCS list 41 genes that inherited cancer...
Abstract Lung cancer is the leading causes of deaths. β-Escin a triterpene saponin isolated from horse chestnut (Aesculus hippocastanum) seeds, had tested on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung adenoma and adenocarcinoma formation in female A/J mice its possible mode action was evaluated using human cell lines (H460 H2126). For bioassay, at 6 weeks age, were randomized fed control AIN-76A modified diet. At 7 age (25 mice/group) intended for carcinogen treatment...
e18755 Background: The 2016 21 st Century Cures Act supports the use of Real-World Data (RWD) for regulatory decision/approval. Due to technological advances, a vast amount health-related data are now available, but most not standardized nor readily useable research. Also, currently available RWD models applicable across cancer types or oncology specialties (surgery, medical oncology, radiation pathology, radiology, etc.). To address these deficiencies Memorial Sloan Kettering Cancer Center...
Each health district in the UK aims to provide services for cancer patients from time of diagnosis death. The role palliative care unit district-based management is still developing. This paper presents data which were part an informal study investigating areas uncertainty, dissatisfaction and controversy perceived by both health-care professionals about local with breast within a single district. In this report we consider attitudes provision terminal these discuss implications integration...
Abstract The increased use of next‐generation sequencing has led to the detection pathogenic TP53 variants in germline setting patients without a personal or family history consistent with Li–Fraumeni syndrome (LFS). These can represent low‐penetrance LFS, mosaic clonal hematopoiesis indeterminate potential. Additionally, uncertain significance be detected suspicious for LFS. interpretation these challenging but is crucial an accurate diagnosis and appropriate medical management. This...
The German healthcare system is characterized by digital change. In recent years, a trend towards the entry of start-ups and medium-sized enterprises into this sector has developed. These types companies in particular are facing enormous challenges due to industry ongoing This article presents fundamental developments these companies. Further solutions developed Tech4Age research group presented briefly. Finally, describes how can be integrated formal concept for promotion further...
e18775 Background: The production of high-quality real-world data requires comprehensive and meticulous quality assurance (QA) methods to guarantee that adequate standards accuracy, completeness, consistency are met. Memorial Sloan Kettering Cancer Center (MSKCC) synthesizes manually curated Electronic Health Record (EHR) collect harmonize the fundamental elements across all cancer types. Centralized real-time analysis can allow for rigorous review identify areas strength opportunities...