A5086850551- RNA modifications and cancer
- BRCA gene mutations in cancer
- DNA Repair Mechanisms
- RNA Research and Splicing
- Genomic variations and chromosomal abnormalities
- RNA regulation and disease
- CRISPR and Genetic Engineering
- Nutrition, Genetics, and Disease
- RNA and protein synthesis mechanisms
- Circular RNAs in diseases
- Pharmacological Effects of Natural Compounds
- Cancer-related gene regulation
- FOXO transcription factor regulation
- Cytomegalovirus and herpesvirus research
- Cancer Immunotherapy and Biomarkers
- Advances in Oncology and Radiotherapy
- Genetic factors in colorectal cancer
- Vitamin D Research Studies
- Cancer-related molecular mechanisms research
- Economic and Financial Impacts of Cancer
- Herpesvirus Infections and Treatments
- Cancer-related Molecular Pathways
- Toxoplasma gondii Research Studies
- Digestive system and related health
- Neuropeptides and Animal Physiology
Henan University Huaihe Hospital and Huaihe Clinical Institute
2024
Huashan Hospital
2024
Fudan University
2024
Henan University
2022
Shaukat Khanum Memorial Cancer Hospital and Research Center
2015-2022
University of Peshawar
2022
London School of Hygiene & Tropical Medicine
2018-2020
Survival from metastatic cutaneous melanoma is substantially lower than for localized disease. Treatments have been limited, but remarkable clinical improvements reported in trials the last decade. We described characteristics of US patients diagnosed with during 2001-2013 and assessed trends short-term survival distant-stage disease.Trends 1-year net were estimated using Pohar Perme estimator, controlling background mortality life tables all-cause rates by county residence, single year age,...
Abstract RNA-binding proteins (RBPs) modulate the expression level of several target RNAs (such as mRNAs) post-transcriptionally through interactions with unique binding sites in 3′-untranslated region. There is mounting information that suggests RBP dysregulation plays a significant role carcinogenesis. However, function FMR1 autosomal homolog 1(FXR1) malignancies just beginning to be unveiled. Due diversity their domains and functional adaptability, FXR1 can regulate diverse transcript...
Post-transcriptional regulation by RNA-binding proteins (RBPs) is critical for mRNA stability, localization, and translation, primarily through interaction with the 3’-untranslated region. Dysregulation of RBPs has been associated various cancers, fragile X-related protein 1 (FXR1) emerging as a RBP involved in tumorigenesis its interactions target mRNAs. Despite significance, specific role FXRI cancer progression remains underexplored. In this study, we investigated...
Background Vitamin D is postulated to decrease the risk of breast cancer by inhibiting cell proliferation via vitamin receptor (VDR). Two common single nucleotide polymorphisms (SNPs) in VDR gene, rs1544410 (BsmI) and rs2228570 (FokI), are inconsistently associated with Caucasian populations, while data for Asians scarce. Here, we investigated possible contribution these SNPs Pakistani patients controls participating a hospital-based case-control study (PAK-BCCC). Methods Genotyping BsmI...
Pathogenic germline mutations in BRCA1 and BRCA2 (BRCA1/2) account for the majority of hereditary breast and/or ovarian cancers worldwide. To refine spectrum BRCA1/2 to accurately estimate prevalence mutation Pakistani population, we studied 539 cancer patients selected family history age diagnosis.Comprehensive screening was performed using state-of-the-art technologies.A total 133 deleterious were identified families (24.7%), comprising 110 23 BRCA2. The small-range large genomic...
The current work examined the pharmacological potential of a selected flavanone derivative 2-hydroxyflavanone as promising remedy for treatment and management pain. (2-HF) was evaluated its analgesic anti-inflammatory potentials following standard protocols including hot plate, acetic acid-induced writhing tail immersion tests. Naloxone pentylenetetrazol were used to evaluate implication GABAergic opioidergic mechanisms. 2-HF confirmed using carrageenan-, serotonin- histamine-induced paw...
Partner and localizer of BRCA2 (PALB2) is a breast cancer susceptibility gene that plays an important role in DNA repair. This the first study assessing prevalence PALB2 mutations early-onset familial breast/ovarian patients from Pakistan.
The growing body of evidence suggests that RNA-binding proteins (RBPs) have an important function in cancer biology. This research characterizes the expression status fragile X-related protein 1 (FXR1) esophageal (ESCA) cell lines and understands its mechanistic importance ESCA tumor
Abstract Background The RecQ Like Helicase ( RECQL ) gene has previously been shown to predispose breast cancer mainly in European populations, particular estrogen receptor (ER) and/or progesterone (PR) positive tumor. Here, we investigated the contribution of pathogenic germline variants hereditary early-onset and familial patients from Pakistan. Methods Comprehensive variant analysis was performed 302 BRCA1 BRCA2 negative with ER PR tumors using denaturing high-performance liquid...
Since decades ago, circular RNAs (circRNAs) have been known for their critical role in RNA maturation, transportation, epigenetic regulation, gene transcription, peptide/protein translation, and interaction with proteins to modulate activities. At present, circRNAs are being extensively studied as oncotargets the onset development of several malignancies treatment resistance by modulating various signaling pathways cellular processes such ubiquitination, degradation, invasion, proliferation,...
Breast cancer is a heterogeneous disease. Several genetic, environmental and lifestyle factors are involved in the aetiology of this Genetic risk include alterations (mutations) genes conferring risks to develop breast cancer. Depending on associated lifetime malignancy, these categorised into high-, moderate- low-risk genes. Women carrying mutations at an increased cancer, ovarian several other malignancies. carcinoma most reported malignancy Pakistani females. Pakistan developing country...
An amendment to this paper has been published and can be accessed via the original article.