A5031735641- Computational Drug Discovery Methods
- Natural product bioactivities and synthesis
- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Bioactive Compounds and Antitumor Agents
- Pharmacological Effects of Natural Compounds
- Synthesis and biological activity
- Natural Antidiabetic Agents Studies
- Phytochemical compounds biological activities
- Medicinal Plants and Bioactive Compounds
- Phytochemicals and Antioxidant Activities
- Cancer Mechanisms and Therapy
- Cholinesterase and Neurodegenerative Diseases
- Drug-Induced Hepatotoxicity and Protection
- Phytochemistry and Biological Activities
- Microbial Metabolism and Applications
- Flavonoids in Medical Research
- Morinda citrifolia extract uses
- Genomics, phytochemicals, and oxidative stress
- Plant Stress Responses and Tolerance
- Essential Oils and Antimicrobial Activity
- Alzheimer's disease research and treatments
- Medicinal Plant Extracts Effects
- Medicinal Plants and Neuroprotection
- GABA and Rice Research
Shanghai Jiao Tong University
2018-2024
Chinese Academy of Sciences
2023-2024
Nishtar Medical College and Hospital
2023
Zhejiang University
2016-2021
Gomal University
2019
University of Arizona
2018
Zhejiang Ocean University
2016-2017
Dalhousie University
2017
Uppsala University
2015
Henry Ford Hospital
2013
Compounds derived from plants have several anticancer properties. In the current study, one guaiane-type sesquiterpene dimer, vieloplain F, isolated
Natural products of herbal origin are prodigious to display diverse pharmacological activities. In the present study, five guaiane-type sesquiterpene dimers, xylopidimers A - E (1-5), isolated from Xylopia vielana species were tested against COX-2 protein target (PDB: 1CX2), a potent for anti-inflammatory agents. To better understand properties all these compounds, in this work, systemic silico study was performed on A-E using molecular docking, ADMET analysis and MD simulations. During...
Elicitation through abiotic stress, including chemical elicitors like heavy metals, is a new technique for drug discovery. In this research, the effect of metals on actinobacteria Streptomyces sp. SH-1312 secondary metabolite production, with strong pharmacological activity, along pharmacokinetics profile, was firstly investigated. The optimum metal stress conditions consisted strain addition mix (Co2+ + Zn2+) ions at 0.5 mM in Gause's medium. Under these conditions, anhydromevalonolactone...
Prostate cancer (PCa) is the most common in men, accounting for approximately 10% of all new cases United States. Plant-derived bioactive compounds, such as pentacyclic triterpenoids (PTs), have ability to inhibit PCa cell proliferation. We isolated and characterized nummularic acid (NA), a potent PT, major chemical constituent Ipomoea batatas, medicinal food plant used ethnomedicine centuries. In current study, vitro antiproliferative potential against cells (DU145 PC3) via...
In the current study, a series of new (2S,3S)-2-(4-isopropylbenzyl)-2-methyl-4-nitro-3-phenylbutanals (FM1-6) with their corresponding carboxylic acid analogues (FM7-12) has been synthesized. Initially, aldehydic derivatives were isolated in diastereomeric form, and structures confirmed NMR, MS elemental analysis. Based on encouraging results vitro COX 1/2, 5-LOX antioxidant assays, we oxidized compounds obtained pure single (major) diastereomer for activities. Among all compounds, FM4, FM10...
Pharmacological strategies to lower the viral load among patients suffering from severe diseases were researched in great detail during SARS-CoV-2 outbreak. The protease Mpro (3CLpro) is necessary for replication and main therapeutic targets proposed, thus far. To stop pandemic spreading, researchers are working find more effective inhibitors against SARS-CoV-2. 33.8 kDa of SARS-CoV-2, being a nonhuman homologue, has possibility utilized as target coronaviruses. develop drug-like compounds...
To find drugs suitable for repositioning use against leukemia, samples from patients with chronic lymphocytic, acute myeloid and lymphocytic leukemias as well peripheral blood mononuclear cells (PBMC) were tested in response to 1266 compounds the LOPAC(1280) library (Sigma). Twenty-five defined hits activity all leukemia subgroups (<50% cell survival compared control) at 10 μM drug concentration. Only one of these compounds, quinacrine, showed low normal PBMCs was therefore selected further...