A5033653473- Pulmonary Hypertension Research and Treatments
- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Metabolism and Genetic Disorders
- Mitochondrial Function and Pathology
- Cardiac Arrhythmias and Treatments
- Cardiovascular Effects of Exercise
- Cardiovascular Issues in Pregnancy
- Cardiac Valve Diseases and Treatments
- Advanced MRI Techniques and Applications
- Neonatal Respiratory Health Research
- Adipose Tissue and Metabolism
- Coronary Artery Anomalies
- Cardiac pacing and defibrillation studies
- Heart Failure Treatment and Management
- Diet and metabolism studies
- Birth, Development, and Health
- Cardiac Arrest and Resuscitation
- Cardiomyopathy and Myosin Studies
- Cardiovascular and exercise physiology
- Peroxisome Proliferator-Activated Receptors
- Vascular Anomalies and Treatments
- Liver Disease and Transplantation
- MicroRNA in disease regulation
Erasmus MC
2017-2025
Erasmus MC - Sophia Children’s Hospital
2017-2025
University of Groningen
2013-2022
University Medical Center Groningen
2012-2022
Erasmus University Rotterdam
2021
Adult Congenital Heart Association
2018
Pediatrics and Genetics
2018
Beatrix Kinderziekenhuis
2007-2017
Leiden University Medical Center
2013
Gujarat Institute of Desert Ecology
2009
Rationale: Pulmonary arterial hypertension (PAH) is a degenerative arteriopathy that leads to right ventricular (RV) failure. BRD4 (bromodomain-containing protein 4), member of the BET (bromodomain and extra-terminal motif) family, has been identified as critical epigenetic driver for cardiovascular diseases.Objectives: To explore therapeutic potential in PAH RVX208, clinically available inhibitor.Methods: Microvascular endothelial cells, smooth muscle cells isolated from distal pulmonary...
The transition from reversible to irreversible pulmonary arterial hypertension involves vascular senescence and can be countered by senolysis.
Background— The value of echocardiography in assessing disease severity and predicting outcome pediatric pulmonary arterial hypertension (PAH) is insufficiently defined. aim this study was to describe correlations between PAH. Methods Results— Forty-three consecutive children (median age, 8.0 years; range, 0.4–21.5) with idiopathic/hereditary PAH (n=25) or associated congenital heart (n=18) were enrolled a prospective single-center observational study. Anatomic right ventricular-functional...
Risperidone is the most commonly prescribed antipsychotic drug to children and adolescents worldwide, but it associated with serious side effects, including weight gain. This study assessed relationship of risperidone 9-hydroxyrisperidone trough concentrations, maximum concentrations 24-hour area under curves (AUCs) body mass index (BMI) z-scores in autism spectrum disorder (ASD) behavioural problems. Secondary outcomes were metabolic, endocrine, extrapyramidal cardiac effects...
Lactate accounts for a third of myocardial oxygen consumption before and in the first 2 weeks after birth. It is unknown how remainder consumed. Glucose thought to be important birth, whereas long-chain fatty acids (LC-FA) are prime substrate adult. However, ability myocardium newborn use LC-FA has been doubted.We measured metabolism glucose with [U-(13)C]glucose [1-(13)C]palmitate chronically instrumented fetal lambs. In lambs, oxidation was high that low. accounted 48+/-4% 2+/-2%...
<h3>Background</h3> Pulmonary arterial hypertension (PAH) is a commonly fatal pulmonary vascular disease that often diagnosed late and characterised by progressive rise in resistance resulting from typical remodelling. Recent data suggest damage plays an important role the development of radiation-induced toxicity. Therefore, authors investigated whether irradiation lung also induces hypertension. <h3>Methods</h3> Different sub-volumes rat were irradiated with protons known to induce...
Right ventricular (RV) failure due to chronically abnormal loading is a main determinant of outcome in pulmonary hypertension (PH) and congenital heart disease. However, distinct types RV have been associated with different outcomes. To determine whether the adaptive response depends on type, we compared hemodynamics, exercise, hypertrophy models pressure overload artery banding (PAB), PH, combined volume overload, isolated load. Ninety-four rats were subjected either PAB,...
Background Patients who have undergone the Fontan procedure are at high risk of circulatory failure. In an exploratory analysis we aimed to determine prognostic value blood biomarkers in a young cohort procedure. Methods and Results multicenter prospective studies patients underwent sampling, cardiopulmonary exercise testing, stress cardiac magnetic resonance imaging. Several including NT-proBNP (N-terminal pro-B-type natriuretic peptide), GDF-15 (growth differentiation factor 15), Gal-3...
Journal Article Accepted manuscript Taming the flame: SerpinB1 suppression of pyroptosis in pathological cardiac hypertrophy Get access Beatrijs Bartelds, MD PhD, PhD Dept op Pediatrics, pediatric cardiology, Erasmus MC- Sophia Children's Hospital, Rotterdam, The Netherlands Email: [email protected] Search for other works by this author on: Oxford Academic PubMed Google Scholar Daphne Merkus, Cardiology, MC, NetherlandsWalter Brendel Center Experimental Medicine, University Clinic Munich,...
<sec> <title>BACKGROUND</title> Wearables are increasingly used in pediatric cardiology for heart rate (HR) monitoring due to advantages over traditional monitoring, such as prolonged time, increased patient comfort and ease of use. However, their validation this population is limited. </sec> <title>OBJECTIVE</title> This study investigates the HR accuracy validity two wearables, CardioWatch bracelet Hexoskin shirt, children attending outpatient clinic. In addition, factors that influence...
Pulmonary regurgitation is a common consequence following the repair of tetralogy Fallot and can lead to heart failure. Early detection right ventricular dysfunction remains challenging, current clinical markers have limited predictive value identify which patients are at risk for failure require interventions. This study aimed investigate potential ventriculo-arterial coupling as marker early in porcine model chronic pulmonary transannular patch neonatal stenosis. Neonatal swine were...
<h3>Objective</h3> In paediatric pulmonary arterial hypertension (PAH), the effectiveness of add-on combination PAH-therapy has not yet been systematically studied. The purpose this study was to determine effect sildenafil therapy in PAH patients treated with bosentan. <h3>Methods</h3> observational within a national patient cohort, follow-up data 24 consecutive initially bosentan monotherapy and prospectively followed at Dutch referral centre for 2007–2013, were reviewed. Patients received...