A5083676168- Pulmonary Hypertension Research and Treatments
- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Cardiovascular Issues in Pregnancy
- Peptidase Inhibition and Analysis
- Signaling Pathways in Disease
- Vascular Anomalies and Treatments
- Cardiac Arrhythmias and Treatments
- Cardiovascular Effects of Exercise
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Mechanical Circulatory Support Devices
- Child and Adolescent Health
- Adenosine and Purinergic Signaling
- Coronary Artery Anomalies
- Telomeres, Telomerase, and Senescence
- Histone Deacetylase Inhibitors Research
- Vascular anomalies and interventions
- Cardiac Fibrosis and Remodeling
- Adipose Tissue and Metabolism
- Physiological and biochemical adaptations
- Apelin-related biomedical research
- Thyroid and Parathyroid Surgery
- Cardiomyopathy and Myosin Studies
- Congenital heart defects research
University Medical Center Groningen
2017-2023
University of Groningen
2017-2022
Dialyse Centrum Groningen
2021
Meander Medisch Centrum
2021
The transition from reversible to irreversible pulmonary arterial hypertension involves vascular senescence and can be countered by senolysis.
For indexing cardiac measures in small animal models, tibia length (TL) is a recommended surrogate for body weight (BW) that aims to avoid biases because of disease-induced BW changes. However, we question if by TL mathematically correct. This study aimed investigate the relation between and BW, heart weight, ventricular weights, left diameter optimize current common practice parameters models. In 29 healthy Wistar rats (age 5-34 wk) 116 Black 6 mice 3-17 wk), appeared scale nonlinearly TL1...
Pulmonary arterial hypertension (PAH) is a fatal disease characterized by increased pulmonary pressure, inflammation, and neointimal remodeling of arterioles. Serum levels interleukin (IL)-1β IL-18 are elevated in PAH patients may enhance proinflammatory remodeling. NLRP3 inflammasome activation induces cleavage the cytokines IL-1β IL-18, required for their secretion. Pirfenidone (PFD), an antifibrotic anti-inflammatory drug, has been suggested to inhibit activation. We hypothesized that PFD...
BackgroundMyocardial strain has been shown to predict outcome in various cardiovascular diseases, including congenital heart diseases. The aim of this study was evaluate the predictive value cardiac magnetic resonance (CMR) feature-tracking derived parameters repaired tetralogy Fallot (rTOF) patients for developing ventricular tachycardia (VT) and deterioration function.MethodsPatients with rTOF who underwent CMR investigation were included. Strain strain-rate both ventricles assessed using...
Abstract Pulmonary arterial hypertension (PAH) is a devastating disease, characterized by obstructive pulmonary vascular remodelling ultimately leading to right ventricular (RV) failure and death. Disturbed transforming growth factor-β (TGF-β)/bone morphogenetic protein (BMP) signalling, endothelial cell dysfunction, increased proliferation of smooth muscle cells fibroblasts, inflammation contribute this abnormal remodelling. Peptidyl-prolyl isomerase Pin1 has been identified as critical...
In this protocol, PAH is induced by combining a 60 mg/kg monocrotalin (MCT) injection with increased pulmonary blood flow through an aorto-caval shunt (MCT+Flow). The created inserting 18-G needle from the abdominal aorta into adjacent caval vein. Increased has been demonstrated as essential trigger for severe form of distinct phases disease progression, characterized early medial hypertrophy followed neointimal lesions and progressive occlusion small vessels. To measure right heart...
Abstract Purpose Substantial differences between sexes exist with respect to cardiovascular diseases, including congenital heart disease. Nevertheless, clinical decisions in the long-term follow-up of patients repaired tetralogy Fallot (rTOF) are currently based on unisex thresholds for cardiac magnetic resonance (CMR) measurements. This study aimed assess whether sex adaptation hemodynamic loading conditions rTOF. Methods and Results cross-sectional, two-center, combined pediatric adult...
Sex is increasingly emerging as determinant of right ventricular (RV) adaptation to abnormal loading conditions. It unknown, however, whether sex-related differences already occur in childhood. Therefore, this study aimed assess sex a juvenile model early RV pressure load by pulmonary artery banding (PAB) during transition from pre postpuberty. Rat pups (n = 57, 3 wk old, 30-45 g) were subjected PAB or sham surgery. Animals euthanized either before after puberty (4 and 8 postsurgery,...
ObjectivesRight ventricular (RV) failure is a leading cause of death in patients with congenital heart disease. RV kept at bay during childhood. Limited proliferation cardiomyocytes present the postnatal heart. We propose that cardiomyocyte improves adaptation to pressure load (PL). studied response increased PL and role cell cycle activity (CCA) rat pups growing into adulthood.MethodsWe induced day weaning rats (3 weeks; 30-40 g) by pulmonary artery banding followed adulthood (300 g)....
With great interest we read the recent article by Wang et al. in Pulmonary Circulation presenting a meta-analysis on efficacy and safety of pulmonary vasodilator therapy patients with Fontan circulation.1 We commend authors this thorough attempt to provide an overview available evidence important controversial topic. The report that they have performed randomized controlled trials (RCTs) conclude therapy, although not reducing mortality, improves peak oxygen consumption (pVO2), hemodynamics,...
Right ventricular (RV) function and failure are key determinants of morbidity mortality in various cardiovascular diseases. Myocardial fibrosis is regarded as a contributing factor to heart failure, but its importance RV has been challenged. This study aims assess whether myocardial drives the transition from compensated decompensated volume load-induced dysfunction.Wistar rats were subjected aorto-caval shunt (ACS, n = 23) or sham (control, 15) surgery, sacrificed after 1 month, 3 months, 6...
In this protocol, PAH is induced by combining a 60 mg/kg monocrotalin (MCT) injection with increased pulmonary blood flow through an aorto-caval shunt (MCT+Flow). The created inserting 18-G needle from the abdominal aorta into adjacent caval vein. Increased has been demonstrated as essential trigger for severe form of distinct phases disease progression, characterized early medial hypertrophy followed neointimal lesions and progressive occlusion small vessels. To measure right heart...
Right ventricular (RV) function and failure are major determinants of outcome in acquired congenital heart diseases, including pulmonary hypertension. Assessment RV morphology is complex, partly due to the complex shape RV. Currently, cardiac magnetic resonance (CMR) imaging golden standard for noninvasive assessment morphology. The current protocol describes CMR a mouse model pressure load induced by artery banding (PAB). PAB performed placing 6-0 suture around over 23 G needle. gradient...
Pulmonary arterial hypertension (PAH) is associated with increased right ventricular (RV) afterload, affecting RV remodeling and performance, a major determinant of outcome in PAH-patients. In children PAH, treatment strategy guided by risk stratification where noninvasive prognosticators are highly needed. The prognostic value characteristics derived cardiac magnetic resonance (CMR) has been scarcely studied pediatric PAH. We aimed to identify CMR-derived morphometric functional for From...
This study aims to assess sex differences with regards outcome, cardiovascular dimensions, and functional capacity in patients a Fontan circulation. In this single-center prospective, standardised cohort of 60 (30 females, 50%) aged ≥10 years, the association between combined outcome variable all-cause mortality, heart/heart-lung transplantation (including listing) Fontan-related hospitalisation was investigated. Secondary measures included ventricular measured by cardiac magnetic resonance...
Abstract Introduction Pulmonary arterial hypertension (PAH) is a progressive fatal disease characterized by abnormal remodelling of pulmonary vessels, leading to increased vascular resistance and right ventricle (RV) failure. This associated with endothelial cell dysfunction, proliferation smooth muscle cells, inflammation, disturbed transforming growth factor beta (TGF-β) signalling. Histone deacetylases (HDACs) have been shown promote inflammation in cells. Although inhibition HDACs using...
Introduction: Pulmonary arterial hypertension (PAH) is a devastating disease, characterized by obstructive pulmonary vascular remodelling ultimately leading to right ventricular (RV) failure and death. Disturbed transforming growth factor-β (TGF-β) / bone morphogenetic protein (BMP) signalling, endothelial cell dysfunction, increased proliferation of smooth muscle cells fibroblasts, inflammation contribute this abnormal remodelling. Peptidyl prolyl isomerase Pin1 has been identified as...