A5007921007- Telomeres, Telomerase, and Senescence
- melanin and skin pigmentation
- Genetic Neurodegenerative Diseases
- RNA regulation and disease
- Pluripotent Stem Cells Research
- Melanoma and MAPK Pathways
- Cytomegalovirus and herpesvirus research
- Immunotherapy and Immune Responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cutaneous Melanoma Detection and Management
- Silk-based biomaterials and applications
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- interferon and immune responses
- Click Chemistry and Applications
- Neuroscience and Neuropharmacology Research
- RNA Interference and Gene Delivery
- CRISPR and Genetic Engineering
- Advanced biosensing and bioanalysis techniques
- Chemical Synthesis and Analysis
- Virology and Viral Diseases
- Immune cells in cancer
- Synthesis and Reactions of Organic Compounds
- Cancer-related Molecular Pathways
- Biomedical Ethics and Regulation
St George's, University of London
2014-2023
University College London
2023
University Medical Center Groningen
2017-2022
University of Groningen
2017-2021
Institute of Oncology Research
2019
Università della Svizzera italiana
2019
University of Lausanne
2019
Veneto Institute of Molecular Medicine
2019
University of Nottingham
2013-2014
Queen's Medical Centre
2013
The transition from reversible to irreversible pulmonary arterial hypertension involves vascular senescence and can be countered by senolysis.
Abstract Human melanocytic nevi (moles) result from a brief period of clonal expansion melanocytes. As cellular defensive mechanism against oncogene-induced hyperplasia, nevus-resident melanocytes enter senescent state stable cell cycle arrest. Senescent can persist for months in mice and years humans with risk to escape the progress melanoma. The mechanisms providing prolonged survival remain poorly understood. Here, we show that culture express high level anti-apoptotic BCL-2 family member...
Axon degeneration precedes cell body death in many age-related neurodegenerative disorders, often determining symptom onset and progression. A sensitive method for revealing axon pathology could indicate whether this is the case also Huntington's disease (HD), a fatal, devastating disorder causing progressive deterioration of both physical mental abilities, which brain region affected first. We studied spatio-temporal relationship between pathology, neuronal loss, mutant Huntingtin aggregate...
Abstract Located in the basal epidermis and hair follicles, melanocytes of integument are responsible for its coloration through production melanin pigments. Melanin is produced a type lysosome‐related‐organelle (LRO) called melanosome. In humans, this skin pigmentation acts as an ultraviolet radiation filter. Abnormalities division quite common, with potentially oncogenic growth usually followed by cell senescence producing benign naevi (moles), or occasionally, melanoma. Therefore, useful...
p16Ink4a is a potent cell cycle inhibitor engaged to support arrest during cellular senescence. However, in tumors carrying mutations key downstream effectors, highly expressed but fails block proliferation. p16Ink4a-overexpressing tumor cells are aggressive and no targeted interventions available. To study the effect of specific therapies, we generated murine sarcomas by overexpressing RAS oncogene disrupting p53 activity. We observed that p16Ink4a-overxpressing sarcoma were resistant...
// Jaskaren S. Kohli 1, 6 , Hira Mir 2, 7 Afsheen Wasif Heung Chong 2 Victoria Akhras 3 Rajiv Kumar 4 Eduardo Nagore 5 and Dorothy C. Bennett 1 Molecular Clinical Sciences Research Institute, St George's, University of London, UK Department Cellular Pathology, George's Hospitals NHS Foundation Trust, Dermatology, Division Genetic Epidemiology, German Cancer Center, Heidelberg, Germany Instituto Valenciano de Oncología, Valencia, Spain Current/Present address: European Institute for The...
Human melanocytic nevi (moles) result from a brief period of clonal expansion melanocytes. As cellular defensive mechanism against oncogene-induced hyperplasia, nevus-resident melanocytes enter senescent state stable cell cycle arrest. Senescent can persist for months in mice and years humans with significant risk to escape the progress melanoma. The mechanisms providing prolonged survival remain poorly understood. Here, we show that culture express high level anti-apoptotic BCL-2 family...