A5063284995- Nitric Oxide and Endothelin Effects
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Heart Rate Variability and Autonomic Control
- Cardiac Imaging and Diagnostics
- Cardiovascular and exercise physiology
- Cardiovascular Effects of Exercise
- Cardiovascular Disease and Adiposity
- Cardiac Ischemia and Reperfusion
- Cardiac electrophysiology and arrhythmias
- Cardiac Fibrosis and Remodeling
- Cardiomyopathy and Myosin Studies
- Renin-Angiotensin System Studies
- Adenosine and Purinergic Signaling
- Adipose Tissue and Metabolism
- Cardiac Arrest and Resuscitation
- Pregnancy and preeclampsia studies
- Neonatal Respiratory Health Research
- Eicosanoids and Hypertension Pharmacology
- Pharmacological Effects and Assays
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Cardiovascular Issues in Pregnancy
- Congenital Heart Disease Studies
- Animal Nutrition and Physiology
Ludwig-Maximilians-Universität München
2019-2025
Erasmus MC
2016-2025
Erasmus University Rotterdam
2015-2025
German Centre for Cardiovascular Research
2019-2025
Centre of Experimental Medicine of the Slovak Academy of Sciences
2022-2024
LMU Klinikum
2024
Institute of Experimental Cardiology
2007-2023
München Klinik
2023
Research Network (United States)
2020
RELX Group (United States)
2020
More than 50% of patients with heart failure have preserved ejection fraction characterized by diastolic dysfunction. The prevalance dysfunction is higher in females and associates multiple comorbidities such as hypertension (HT), obesity, hypercholesterolemia (HC), diabetes mellitus (DM). Although its pathophysiology remains incompletely understood, it has been proposed that these induce systemic inflammation, coronary microvascular dysfunction, oxidative stress, leading to myocardial...
Angiogenesis inhibition with agents targeting tyrosine kinases of vascular endothelial growth factor receptors is an established anticancer treatment, but is, unfortunately, frequently accompanied by systemic hypertension and cardiac toxicity. Whether receptor antagonism also has adverse effects on the pulmonary coronary circulations presently unknown. In chronically instrumented awake swine, antagonist sunitinib systemic, pulmonary, circulation were studied. One week after (50 mg PO daily),...
Myocardial infarction (MI) initiates cardiac remodeling, depresses pump function, and predisposes to heart failure. This study was designed identify early alterations in Ca2+ handling myofilament proteins, which may contribute contractile dysfunction reduced beta-adrenergic responsiveness postinfarct remodeled myocardium. Protein composition function of skinned cardiomyocytes were studied remote, noninfarcted left ventricular (LV) subendocardium from pigs 3 weeks after MI caused by permanent...
Vagal nerve stimulation (VNS) started prior to, or during, ischemia has been shown to reduce infarct size. Here, we investigated the effect of VNS when just and continued during early, reperfusion on size no-reflow studied underlying mechanisms. For this purpose, swine (13 VNS, 10 sham) underwent 45 min mid-LAD occlusion followed by 120 reperfusion. was 5 until 15 Area at risk, area (% area) risk), circulating cytokines, regional myocardial leukocyte influx were assessed after significantly...
Distal to a chronic coronary artery stenosis, structural remodeling of the microvasculature occurs. The microvascular functional changes distal stenosis have not been studied in detail. We tested hypothesis that is accompanied by altered regulation vasomotor tone with increased responsiveness endothelin-1. Vasomotor was microvessels from healthy control swine and 3 4 months after implantation an occluder causes progressive narrowing, resulting regional left ventricular dysfunction blunted...
Only few preliminary experimental studies demonstrated the feasibility of adenosine stress CT myocardial perfusion imaging to calculate absolute blood flow (MBF), thereby providing information whether a coronary stenosis is limiting. Therefore, aim our study was determine by Dual Source (DSCT) enables non-invasive quantification regional MBF in an animal model with various degrees reduction. In seven pigs, probe and adjustable hydraulic occluder were placed around left anterior descending...
Coronary microvascular dysfunction (CMD) has been proposed as an important component of diabetes mellitus (DM)- and hypercholesterolemia-associated coronary artery disease (CAD). Previously we observed that 2.5 mo DM high-fat diet (HFD) in swine blunted bradykinin (BK)-induced vasodilation attenuated endothelin (ET)-1-mediated vasoconstriction. Here studied the progression CMD after 15 same animal model CAD. Ten male were fed a HFD absence (HFD, n = 5) or presence streptozotocin-induced (DM...
Abstract Comorbidities of ischemic heart disease, including diabetes mellitus (DM), hypercholesterolemia (HC) and chronic kidney disease (CKD), are associated with coronary microvascular dysfunction (CMD). Increasing evidence suggests that CMD may contribute to myocardial ‘Ischemia No Obstructive Coronary Artery disease’ (INOCA). In the present study, we tested hypothesis results in perturbations perfusion oxygen delivery using a novel swine model multiple comorbidities. DM (streptozotocin),...
Journal Article Accepted manuscript Taming the flame: SerpinB1 suppression of pyroptosis in pathological cardiac hypertrophy Get access Beatrijs Bartelds, MD PhD, PhD Dept op Pediatrics, pediatric cardiology, Erasmus MC- Sophia Children's Hospital, Rotterdam, The Netherlands Email: [email protected] Search for other works by this author on: Oxford Academic PubMed Google Scholar Daphne Merkus, Cardiology, MC, NetherlandsWalter Brendel Center Experimental Medicine, University Clinic Munich,...
Very preterm-born infants are at risk for developing bronchopulmonary dysplasia (BPD), a chronic lung disease. Nowadays, the majority of these reach adulthood. young adults pulmonary arterial (PA) hypertension later in life. An early sign PA is increased stiffness. This study aims to use cardiovascular magnetic resonance compare stiffness using relative area change (RAC) and pulse wave velocity (PWV) identify signs born very premature, with without BPD. Twenty 20 BPD underwent were compared...
Pulmonary regurgitation is a common consequence following the repair of tetralogy Fallot and can lead to heart failure. Early detection right ventricular dysfunction remains challenging, current clinical markers have limited predictive value identify which patients are at risk for failure require interventions. This study aimed investigate potential ventriculo-arterial coupling as marker early in porcine model chronic pulmonary transannular patch neonatal stenosis. Neonatal swine were...
Objectives: Exercise-induced vasodilation is thought to be mediated through various vasodilator substances, but blunting the influence of vasoconstrictors such as ET may also play a role. However, role and its receptors in regulation systemic, pulmonary coronary vascular resistance incompletely understood. The aim this study was identify contribution ET-1 ETA ETB tone beds at rest during exercise. Methods: Ten chronically instrumented swine were studied while running on treadmill before...