Abstract Background Cardiac sarcoidosis (CS) is associated with poor prognosis, making early diagnosis and treatment important. This study evaluated the results of a diagnostic approach in patients known suspected cardiac involvement tertiary centre their long-term outcomes. Methods We included 180 clinical suspicion CS. In addition to an electrocardiogram (ECG)/transthoracic echocardiogram (TTE), cardiovascular magnetic resonance imaging (CMR) positron emission tomography (PET) were...

Abstract Objectives The aim of this study was to assess the effect a deep learning (DL)–based reconstruction algorithm on late gadolinium enhancement (LGE) image quality and evaluate its influence scar quantification. Methods Sixty patients (46 ± 17 years, 50% male) with suspected or known cardiomyopathy underwent CMR. Short-axis LGE images were reconstructed using conventional DL network (DLRecon) tunable noise reduction (NR) levels from 0 100%. Image standard DLRecon 75% NR scored 5-point...

Very preterm-born infants are at risk for developing bronchopulmonary dysplasia (BPD), a chronic lung disease. Nowadays, the majority of these reach adulthood. young adults pulmonary arterial (PA) hypertension later in life. An early sign PA is increased stiffness. This study aims to use cardiovascular magnetic resonance compare stiffness using relative area change (RAC) and pulse wave velocity (PWV) identify signs born very premature, with without BPD. Twenty 20 BPD underwent were compared...

•CAD was just as common in controls hypertrophic cardiomyopathy patients.•Myocardial bridging twice prevalent patients.•CT performs well the evaluation of chest pain cardiomyopathy. The etiology (HC) is diverse and includes coronary artery disease (CAD) HC-specific causes. Myocardial (MB) has been associated with HC, pain, accelerated atherosclerosis. We compared HC patients age-, gender- CAD pre-test probability-matched outpatients presenting to investigate differences presence MB using...

Long-term survivors of Hodgkin lymphoma (HL) and mediastinal non-Hodgkin experience late adverse effects radiotherapy and/or anthracycline-containing chemotherapy, leading to premature cardiovascular morbidity mortality. The aim this study was identify markers for subclinical disease using magnetic resonance (CMR) in HL lymphoma. CMR performed 80 treated with or without anthracyclines, results were compared those among 40 healthy control subjects matched age sex. Of the survivors, 98% had...

The purpose of this study was to compare invasively measured aorta flow with 2D phase contrast and 4D measurements by cardiovascular magnetic resonance (CMR) imaging in a large animal model. Nine swine (mean weight 63 ± 4 kg) were included the study. CMR exams performed on 1.5T MRI scanner. Flow images at aortic valve level, ascending aorta, main pulmonary artery. Simultaneously, using an invasive probe, placed around aorta. Additionally, standard left ventricular (LV) volumetric data used...

Background Late gadolinium enhancement and left ventricular (LV) ejection fraction on cardiovascular magnetic resonance (CMR) are prognostic markers, but their predictive value for incident heart failure or life‐threatening arrhythmias in acute myocarditis patients is limited. CMR‐derived feature tracking provides a more sensitive analysis of myocardial function may improve risk stratification myocarditis. In this study, the LV, right ventricular, atrial strain evaluated. Methods Results...

Cardiovascular magnetic resonance (CMR) phase contrast (PC) flow measurements suffer from offset errors. Background subtraction based on stationary phantom can most reliably be used to overcome this inaccuracy. Stationary tissue correction is an alternative and does not require additional scanning. The aim of study was 1) compare with without corrected different GE Healthcare CMR scanners using software packages 2) evaluate the clinical implications these methods.

Genetic testing in relatives of hypertrophic cardiomyopathy (HCM) patients leads to early identification pathogenic DNA variant carriers (G+), before the onset left ventricular hypertrophy. Routine phenotyping consists electrocardiography (ECG) and transthoracic echocardiography (TTE). Cardiovascular magnetic resonance (CMR) has become valuable work-up HCM. In this study, we investigated value CMR G+ family members.This study included 91 subjects who underwent ECG, TTE CMR, with a maximal...

Right ventricle (RV) function is the most important determinant of survival and quality life in patients with chronic thromboembolic pulmonary hypertension (CTEPH). The changes right left gene expression that contribute to ventricular remodelling are incompletely investigated. RV our CTEPH swine model associated increased genes involved inflammation (TGFβ), oxidative stress (ROCK2, NOX1 NOX4), apoptosis (BCL2 caspase-3). Alterations ROCK2 correlated inversely contractile reserve during...

Abstract Background Family screening for hypertrophic cardiomyopathy (HCM) is based on genetic testing and clinical evaluation (maximal left ventricular wall thickness (MWT) ≥15 mm, or ≥13 mm in first-degree relatives of HCM patients). The aim this study was to assess the effect gender body size diagnosis prediction outcome. Methods This includes 199 genotype-positive subjects (age 44 ± 15 years, 50% men) referred cardiac screening. Gender-specific reference values MWT indexed by surface...

Background Worldwide, 1–2% of children are born premature and at risk for developing bronchopulmonary dysplasia (BPD). Preterm-born adults early cardiovascular disease. The role BPD is unclear. This study aims to examine cardiorespiratory function during submaximal exercise in young adult survivors extreme prematurity, with or without BPD. Methods 40 preterm-born adults, 20 (median gestational age 27 weeks, interquartile range (IQR) 26–28 weeks) 28 IQR 27–29 were prospectively compared...

Background: Carriers of pathogenic DNA variants (G+) causing hypertrophic cardiomyopathy (HCM) can be identified by genetic testing. Several abnormalities have been brought forth as pre-clinical expressions HCM, some which cardiovascular magnetic resonance (CMR). In this study, we assessed morphological differences between G+/left ventricular hypertrophy-negative (LVH-) subjects and healthy controls examined whether CMR-derived variables are useful for the prediction sarcomere gene variants....

Abstract Funding Acknowledgements Type of funding sources: None. Background Long-term survivors Hodgkin (HL) and non-Hodgkin (NHL) lymphomas experience late adverse effects mediastinal radiotherapy and/or anthracycline containing chemotherapy, which lead to premature cardiovascular morbidity mortality. It is unknown whether early stages myocardial dysfunction heart failure in these can be detected by magnetic resonance imaging (CMR). Purpose To identify sensitive markers for the detection...

Abstract Funding Acknowledgements Type of funding sources: None. Background Cardiac magnetic resonance (CMR) plays a major role in both the diagnostic process and prognostic stratification acute myocarditis. Presence late gadolinium enhancement (LGE) left ventricular (LV) ejection fraction (EF) are known predictors adverse cardiovascular events (MACE). However, daily clinical practice it remains challenging to distinguish ‘the good from bad’. The value CMR feature tracking (FT) derived...

Abstract Background Phase contrast (PC) CMR flow measurements (FM) are widely used for blood assessment, but they suffer from phase offset errors (POE). Stationary phantom correction limits these inaccuracies, however, this adds scan time. tissue (ST) is an alternative method that does not require additional scanning. The aim of study was to evaluate the impact POE, assess interscanner variation, and ST usage. Methods We included 166 patients in which both aorta main pulmonary artery FM were...

Abstract Funding Acknowledgements None. Introduction The etiology of chest pain in hypertrophic cardiomyopathy (HCM) is diverse and includes coronary artery disease (CAD) as well HCM-specific causes. Myocardial bridging (MB) has been associated with HCM, pain, accelerated atherosclerosis. To investigate differences the presence MB CAD, we compared HCM patients age-, gender- CAD pre-test probability (PTP)-matched outpatients presenting pain. Methods We studied 84 who underwent cardiac...

Abstract Background Cardiac sarcoidosis (CS) is associated with poor prognosis, making early diagnosis and treatment important. The aim of this study to evaluate our diagnostic results follow-up for the CS in a tertiary center. Methods We studied 188 patients proven extra-cardiac referred outpatient clinic evaluation cardiac involvement. Eight were excluded because electrocardiogram (ECG) and/or transthoracic echocardiography (TTE) was missing. magnetic resonance (CMR) positron emission...

Abstract Funding Acknowledgements Type of funding sources: None. Carriers pathogenic DNA variants (G+) causing hypertrophic cardiomyopathy (HCM) can be identified by genetic testing, before manifestation left ventricular hypertrophy (LVH). These G+/LVH- subjects are routinely monitored for phenotypic expression, which, alongside LVH, include other HCM-related abnormalities, including crypts and myocardial fibrosis. Cardiovascular magnetic resonance (CMR) imaging has emerged as a valuable...

Abstract Funding Acknowledgements Type of funding sources: None. Genetic testing in relatives hypertrophic cardiomyopathy (HCM) patients can lead to early identification carriers pathogenic DNA variants (G+), before onset left ventricular hypertrophy (LVH). Repeated evaluation by electrocardiography (ECG) and transthoracic echocardiography (TTE) is recommended detect HCM during follow-up. Cardiovascular magnetic resonance (CMR) imaging has become valuable the work-up HCM, although its role...