A5053239906- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular and exercise physiology
- Nitric Oxide and Endothelin Effects
- Neurogenetic and Muscular Disorders Research
- Intensive Care Unit Cognitive Disorders
- Cardiovascular Effects of Exercise
- Congenital Heart Disease Studies
- Heart Rate Variability and Autonomic Control
- Cardiomyopathy and Myosin Studies
- Congenital Diaphragmatic Hernia Studies
- Infant Development and Preterm Care
- Anesthesia and Neurotoxicity Research
Erasmus University Rotterdam
2020-2025
Erasmus MC
2019-2025
Erasmus MC - Sophia Children’s Hospital
2024
Research Network (United States)
2020
RELX Group (United States)
2020
Very preterm-born infants are at risk for developing bronchopulmonary dysplasia (BPD), a chronic lung disease. Nowadays, the majority of these reach adulthood. young adults pulmonary arterial (PA) hypertension later in life. An early sign PA is increased stiffness. This study aims to use cardiovascular magnetic resonance compare stiffness using relative area change (RAC) and pulse wave velocity (PWV) identify signs born very premature, with without BPD. Twenty 20 BPD underwent were compared...
Background Worldwide, 1–2% of children are born premature and at risk for developing bronchopulmonary dysplasia (BPD). Preterm-born adults early cardiovascular disease. The role BPD is unclear. This study aims to examine cardiorespiratory function during submaximal exercise in young adult survivors extreme prematurity, with or without BPD. Methods 40 preterm-born adults, 20 (median gestational age 27 weeks, interquartile range (IQR) 26–28 weeks) 28 IQR 27–29 were prospectively compared...
Abstract Pulmonary hypertension is common in heart failure with preserved ejection fraction (HFpEF). Here, we tested the hypothesis that comorbidities [diabetes mellitus (DM, streptozotocin), hypercholesterolemia (HC, high-fat diet) and chronic kidney disease (CKD, renal microembolization)] directly impair pulmonary vasomotor control a DM + HC CKD swine model. 6 months after induction of CKD, arterial pressure was similar chronically instrumented female ( n = 19) Healthy 18). However,...
Prematurely born young adults who experienced neonatal oxidative injury (NOI) of the lungs have increased incidence cardiovascular disease. Here, we investigated long-term effects NOI on cardiopulmonary function in piglets at age 10-12 weeks. To induce NOI, term-born (1.81 ± 0.06 kg) were exposed to hypoxia (10-12%
Cardiovascular magnetic resonance (CMR) imaging during supine exercise at (sub)maximal oxygen consumption (VO2 ) offers unique diagnostic insights. However, maximal VO2 is not achievable in the position and standardizing submaximal intensities remains challenging. Using heart rate or workload could be a viable option to translate -based intensities.To upright cycling (UCE) push-pull (SPPE), by comparing determined UCE, with SPPE similar intensities.Sixteen healthy young adults (20.4 ± 2.2...
Aims & Objectives: Children on extracorporeal membrane oxygenation (ECMO) experience negative sequelae of immobility. However, staff concerns about safety are a barrier for early mobilization (EM) in these patients. EM critically ill children is found to be beneficial. To promote pediatric ECMO patients, protocol has been implemented. Our objective was evaluate the feasibility Methods: A retrospective analysis patients ECMO, admitted tertiary PICU, after implementation protocol. Patients'...
Aims & Objectives: Immobility negatively affects muscle weakness, circadian rhythm, and potentially increases the risk of delirium. Providing early mobilization (EM) during Intensive Care Unit (ICU) stay has shown effective in adults. Objective: We determined feasibility safety implementation an EM program a Pediatric ICU (PICU). Methods: A prospective pre-posttest study was conducted patients admitted on PICU for at least 3 days. This quality improvement project involved usual care baseline...
Introduction Diabetes mellitus (DM), chronic kidney disease (CKD) and hypercholesterolemia are common co‐morbidities associated with low‐grade inflammation endothelial dysfunction leading to increased systemic vascular resistance, diastolic exercise intolerance. Diastolic is a risk factor for development of post‐capillary pulmonary hypertension (PH), which, in subgroup patients, deteriorates into combined pre‐and PH. This process characterized by an increase resistance (PVR) due remodeling....
Background Pulmonary hypertension (PH) increases workload of the right ventricle (RV), resulting in RV hypertrophy. Eventually is unable to cope with high afterload, failure and death. The transition hypertrophy incompletely understood, but we have recently shown that myocardial oxygen supply did not increase commensurate demand. This mismatch between demand exacerbated during physical activity when hence increases. Here, aim investigate whether contribution vasodilator nitric oxide (NO)...
Introduction Advances in neonatal care improved the survival of very prematurely born infants. Exposure to high oxygen is often necessary ensure adequate uptake these infants, leading halted development and oxidative injury pulmonary vasculature which accompanied by increased arterial pressure (PAP). Although pressures normalize school age childhood, various stressors as hypoxia exercise may unmask vasoreactivity. Furthermore, now that infants reach adulthood, it increasingly recognized this...