A5086741505- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Nitric Oxide and Endothelin Effects
- Cardiac Imaging and Diagnostics
- Cardiovascular and exercise physiology
- Pulmonary Hypertension Research and Treatments
- Heart Failure Treatment and Management
- Adipose Tissue and Metabolism
- Meat and Animal Product Quality
- Animal Nutrition and Physiology
- Cardiac Ischemia and Reperfusion
- Renin-Angiotensin System Studies
- Animal Behavior and Welfare Studies
- Cardiac Fibrosis and Remodeling
- Pharmacological Effects and Assays
- Chronic Kidney Disease and Diabetes
- Platelet Disorders and Treatments
- Cardiomyopathy and Myosin Studies
- Cardiovascular Health and Risk Factors
- Liver Disease and Transplantation
- Heart Rate Variability and Autonomic Control
- Single-cell and spatial transcriptomics
- Erythropoietin and Anemia Treatment
- Blood Coagulation and Thrombosis Mechanisms
- Cardiovascular Syncope and Autonomic Disorders
Erasmus MC
2017-2024
Erasmus University Rotterdam
2017-2023
Dutch Blood Transfusion Society
1991
More than 50% of patients with heart failure have preserved ejection fraction characterized by diastolic dysfunction. The prevalance dysfunction is higher in females and associates multiple comorbidities such as hypertension (HT), obesity, hypercholesterolemia (HC), diabetes mellitus (DM). Although its pathophysiology remains incompletely understood, it has been proposed that these induce systemic inflammation, coronary microvascular dysfunction, oxidative stress, leading to myocardial...
Abstract Comorbidities of ischemic heart disease, including diabetes mellitus (DM), hypercholesterolemia (HC) and chronic kidney disease (CKD), are associated with coronary microvascular dysfunction (CMD). Increasing evidence suggests that CMD may contribute to myocardial ‘Ischemia No Obstructive Coronary Artery disease’ (INOCA). In the present study, we tested hypothesis results in perturbations perfusion oxygen delivery using a novel swine model multiple comorbidities. DM (streptozotocin),...
Albumin is the most abundant protein in blood plasma and acts as a carrier for many circulating molecules. Hypoalbuminaemia, mostly caused by either renal or liver disease malnutrition, can perturb vascular homeostasis involved development of multiple diseases. Here we review four functions albumin consequences hypoalbuminaemia on homeostasis. (i) main determinant colloid osmotic pressure. Hypoalbuminaemia was therefore thought to be mechanism oedema nephrotic syndrome (NS), however,...
Heart failure with a preserved ejection fraction (HFpEF) is associated multiple comorbidities, such as old age, hypertension, type 2 diabetes and obesity more prevalent in females. Although the male obese ZSF1 rat has been proposed suitable model to study development of diastolic dysfunction early HFpEF, studies female animals have not performed yet. Therefore, we aimed characterize cardiac phenotype rats their lean counterparts. Additionally, investigate whether differences exist disease...
Risk factors of parenteral and nonparenteral exposure to hepatitis C virus (HCV) infection were studied in 125 blood donors The Netherlands who positive for anti‐HCV on enzyme‐linked immunosorbent assay (ELISA). related confirmatory test results four‐antigen recombinant immunoblot (4‐RIBA) polymerase chain reaction (PCR) the HCV 5′ untranslated region. Twelve (10%) C100 ELISA‐positive 4‐RIBA positive. Eleven (92%) 12 4‐RIBA‐positive PCR positive, all 113 remaining 4‐RIBA‐negative or...
Abstract It is well known that high von Willebrand factor (VWF) and VIII (FVIII) levels are associated with an increased risk of cardiovascular disease. still debated whether VWF FVIII biomarkers endothelial dysfunction atherosclerosis or they have a direct causative role. Therefore, we aimed to unravel the pathophysiological pathways factors. First, performed randomized controlled trial in 34 Göttingen miniswine. Diabetes mellitus (DM) was induced streptozotocin hypercholesterolemia (HC)...
Multiple common cardiovascular comorbidities produce coronary microvascular dysfunction. We previously observed in swine that a combination of diabetes mellitus (DM), high fat diet (HFD) and chronic kidney disease (CKD) induced systemic inflammation, increased oxidative stress produced endothelial dysfunction, altering control tone via loss NO bioavailability, which was associated with an increase circulating endothelin (ET). In the present study, we tested hypotheses (1) ROS scavenging (2) ET
Abstract Obesity and hypertension are prevalent comorbidities in heart failure with preserved ejection fraction. To clarify if how interaction between these contributes to development of diastolic dysfunction, lean obese ZSF1 rats were treated deoxycorticosterone acetate implants a high‐salt diet (DS) induce severe hypertension, or placebo. In addition echocardiographic, metabolic hemodynamic analyses, immunohistochemistry RNAseq performed on left ventricular tissue. negatively affected...
Abstract The prevalence of diabetic metabolic derangement (DMetD) has increased dramatically over the last decades. Although there is increasing evidence that DMetD associated with cardiac dysfunction, early DMetD-induced myocardial alterations remain incompletely understood. Here, we studied DMetD-related changes in a clinically relevant large animal model. was established adult male Göttingen miniswine by streptozotocin injections and high-fat, high-sugar diet, while control animals...
Objective The objective of this study was to assess the incidence and characteristics patients presenting with physical symptoms that remain medically unexplained at emergency department (ED). Patients methods A retrospective chart carried out in three hospitals Netherlands Belgium. All (age > 18 years) visiting ED 4 selected weeks 2013 Erasmus University Medical Center (Erasmus MC) Rotterdam, Netherlands, 1 week Haaglanden Center, Westeinde HMC Hague, Hospital Ghent (UZG), Belgium, were...
Abstract Natural and active shear wave elastography (SWE) are potential ultrasound-based techniques to non-invasively assess myocardial stiffness, which could improve current diagnosis of heart failure. This study aims bridge the knowledge gap between both discuss their respective impacts on cardiac stiffness evaluation. We recorded mechanical waves occurring after aortic mitral valve closure (AVC, MVC) those induced by acoustic radiation force throughout cycle in four pigs sternotomy. SWE...
Abstract In the present study, we tested hypothesis that multiple risk factors, including diabetes mellitus (DM), dyslipidaemia and chronic kidney disease (CKD) result in a loss of nitric oxide (NO) signalling, thereby contributing to coronary microvascular dysfunction. Risk factors were induced 12 female swine by intravenous streptozotocin injections high fat diet (HFD) renal artery embolization (CKD). Female healthy ( n = 13) on normal served as controls (Normal). After 5 months,...
Abstract Pulmonary hypertension is common in heart failure with preserved ejection fraction (HFpEF). Here, we tested the hypothesis that comorbidities [diabetes mellitus (DM, streptozotocin), hypercholesterolemia (HC, high-fat diet) and chronic kidney disease (CKD, renal microembolization)] directly impair pulmonary vasomotor control a DM + HC CKD swine model. 6 months after induction of CKD, arterial pressure was similar chronically instrumented female ( n = 19) Healthy 18). However,...
The interplay of mechanisms regulating coronary blood flow (CBF) remains incompletely understood. Previous studies in dogs indicated that CBF regulation by KATP channels, adenosine, and nitric oxide (NO) follows a nonlinear redundancy design fully accounted for exercise-induced vasodilation. Conversely, swine, these appear to regulate linear additive fashion with considerable vasodilation remaining when all three are inhibited. A direct comparison between is hampered the different doses...
Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main source(s): Dutch Cardiovascular Alliance Background/Objectives We have previously shown, in female swine that the combination three cardiovascular risk factors (diabetes mellitus (DM), hypercholestolemia (HC) and chronic kidney disease (CKD)) induces systemic inflammation, oxidative stress, coronary endothelial dysfunction impaired myocardial perfusion due to nitric oxide (NO)...
Abstract Introduction Comorbidities of ischemic heart disease, including diabetes mellitus (DM), hypercholesterolemia and chronic kidney disease (CKD), are associated with coronary microvascular dysfunction (CMD) may contribute to myocardial “Ischemia No Obstructive Coronary Artery disease” (INOCA). Purpose We studied perfusion oxygen delivery using a novel swine model multiple comorbidities. Methods DM (streptozotocin), HFD (high fat diet) CKD (renal embolization), were induced in 12 female...
Multiple cardiovascular risk factors, such as diabetes mellitus (DM), chronic kidney disease (CKD) and dyslipidemia are known to induce inflammation microvascular dysfunction contributing impaired myocardial perfusion. We previously observed that a combination of DM, high fat diet (HFD) CKD produced an increase in coronary tone awake swine, resulting perturbations O 2 balance. The increased was mediated by NO bioavailability accompanied levels reactive oxygen species (ROS) circulating...
Abstract Background Heart failure with preserved ejection fraction (HFpEF) is characterized by impaired left ventricular (LV) relaxation and filling due to increased myocardial stiffness hypertrophy. The development of HFpEF associated multiple, interrelated risk factors including obesity, chronic kidney disease (CKD), diabetes mellitus (DM), hypertension. Mechanistic studies have implied that comorbidity-driven inflammation, oxidative stress, endothelial dysfunction act as contributors the...
Abstract Background Multiple cardiovascular risk factors, such as diabetes mellitus (DM), chronic kidney disease (CKD) and dyslipidemia are known to induce inflammation microvascular dysfunction contributing impaired myocardial perfusion. We previously observed that a combination of DM, high fat diet (HFD) CKD produced an increase in coronary tone awake swine, resulting perturbations O2 balance. The increased was mediated by NO bioavailability accompanied levels reactive oxygen species (ROS)...
CAD and comorbidities 1405CKD patients compared to matched controls, the effect of apabetalone treatment on those pathways.Results: Apabetalone PK parameters were similar in controls CKD patients.At baseline, plasma proteomics showed enrichment markers that correlate with progression CKD, as including cystatin C b2 microglobulin (3-fold 5-fold enrichment, respectively, p<0.001).Accordingly, pathway analysis proteome at baseline an upregulation pathways underlie CVD such inflammatory...