A5085085635- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Health and Disease Prevention
- Single-cell and spatial transcriptomics
- Congenital heart defects research
- Cardiac Fibrosis and Remodeling
- GDF15 and Related Biomarkers
- Nutrition and Health in Aging
- Cardiovascular Disease and Adiposity
- Macrophage Migration Inhibitory Factor
- Cell Adhesion Molecules Research
- Heart Failure Treatment and Management
- Epigenetics and DNA Methylation
- Kruppel-like factors research
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Inflammatory Biomarkers in Disease Prognosis
- Cardiac Imaging and Diagnostics
- Birth, Development, and Health
- Renin-Angiotensin System Studies
- Coronary Interventions and Diagnostics
- Cardiac Ischemia and Reperfusion
- Bioinformatics and Genomic Networks
- Hormonal Regulation and Hypertension
- Cardiovascular Function and Risk Factors
- Anesthesia and Pain Management
University Medical Center Utrecht
2017-2024
Utrecht University
2018-2024
Heidelberg University
2020
University Hospital Heidelberg
2020
BACKGROUND: Cell phenotype switching is increasingly being recognized in atherosclerosis. However, our understanding of the exact stimuli for such cellular transformations and their significance human atherosclerosis still evolving. Intraplaque hemorrhage thought to be a major contributor plaque progression part by stimulating influx CD163 + macrophages. Here, we explored hypothesis that macrophages cause through induction proapoptotic endothelial-to-mesenchymal transition (EndMT) within...
Epigenetic age estimators (clocks) are predictive of human mortality risk. However, it is not yet known whether the epigenetic atherosclerotic plaques for risk cardiovascular events.
Tobacco smoking is a major risk factor for atherosclerotic disease and has been associated with DNA methylation (DNAm) changes in blood cells. However, whether influences DNAm the diseased vascular wall unknown but may prove crucial understanding pathophysiology of atherosclerosis. In this study, we current tobacco to epigenome-wide plaques from patients undergoing carotid endarterectomy.DNAm at commonly methylated sites (cytosine-guanine nucleotide pairs separated by phospho-group [CpGs])...
Heart failure with a preserved ejection fraction (HFpEF) is associated multiple comorbidities, such as old age, hypertension, type 2 diabetes and obesity more prevalent in females. Although the male obese ZSF1 rat has been proposed suitable model to study development of diastolic dysfunction early HFpEF, studies female animals have not performed yet. Therefore, we aimed characterize cardiac phenotype rats their lean counterparts. Additionally, investigate whether differences exist disease...
Abstract Rationale Endothelial cells can differentiate into mesenchymal-like via endothelial to mesenchymal transition (EndoMT). In murine models, cell transitions of EndoMT have been assessed with lineage tracing techniques. Knowledge on molecular mechanisms in human vascular lesions is scarce as studies atherosclerosis are limited by observational study designs such histo-pathological studies. Objective We aim identify a gene expression signature combining experimentally induced vitro...
Cardiorenal syndrome type 2 is characterized by kidney failure as a consequence of heart that affects >50% patients. Murine transverse aortic constriction (TAC) model, where pressure overload induced on the without any systemic hypertension or its consequences. Whether renal function altered in this model debated, and if so, at which time post-TAC dysfunction starts to contribute worsening cardiac function. We therefore studied effects progressive development absence chronically...
The rapid advancements in genome-scale (omics) techniques has created significant opportunities to investigate complex disease mechanisms tissues and cells. Nevertheless, interpreting -omics data can be challenging, pathway enrichment analysis is a frequently used method identify candidate molecular pathways that drive gene expression changes. With growing number of studies dedicated atherosclerosis, there been increase hypotheses relying on analysis. This brief review discusses the benefits...
Abstract Background Sex and plaque histology are intertwined, with fibrous atherosclerotic plaques being more prevalent in women pointing to general smooth muscle cell plasticity estrogen signaling. Plaque erosion, a significant contributor acute coronary syndromes (ACSs), is linked as compared men. We hypothesize that the molecular drivers of histologically determined differ between men women. Methods Human end-stage were isolated from consecutive patients who underwent carotid...