A5035658696- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Inflammasome and immune disorders
- Lipoproteins and Cardiovascular Health
- Cardiovascular Function and Risk Factors
- Congenital heart defects research
- Cell Adhesion Molecules Research
- Cancer Genomics and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Protease and Inhibitor Mechanisms
- Immune Response and Inflammation
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac tumors and thrombi
- MicroRNA in disease regulation
- Cardiac Arrhythmias and Treatments
- Epigenetics and DNA Methylation
- Diet and metabolism studies
- Cardiovascular Disease and Adiposity
- Kawasaki Disease and Coronary Complications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer-related gene regulation
- Cardiac Structural Anomalies and Repair
Charité - Universitätsmedizin Berlin
2017-2025
Deutsches Herzzentrum München
2025
Humboldt-Universität zu Berlin
2021-2024
German Centre for Cardiovascular Research
2020-2024
Freie Universität Berlin
2021-2024
Deutsches Herzzentrum der Charité
2023-2024
Franklin University
2021-2024
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2023
Abstract Aims Acute coronary syndromes with intact fibrous cap (IFC-ACS), i.e. caused by plaque erosion, account for approximately one-third of ACS. However, the underlying pathophysiological mechanisms as compared ACS rupture (RFC-ACS) remain largely undefined. The prospective translational OPTICO-ACS study programme investigates first time microenvironment ACS-causing culprit lesions (CL) molecular high-resolution intracoronary imaging and simultaneous local immunological phenotyping....
Abstract Aims Rupture of the fibrous cap (RFC) and erosion an intact (IFC) are two predominant mechanisms causing acute coronary syndromes (ACS). It is uncertain whether clinical outcomes different following RFC-ACS vs. IFC-ACS this affected by a specific inflammatory response. The prospective, translational OPTIcal-COherence Tomography in Acute Coronary Syndrome study programme investigates impact culprit lesion phenotype on profiles prognosis ACS patients. Methods results This analysis...
In one-third of patients with acute coronary syndrome (ACS), thrombosis occurs despite an intact fibrous cap (IFC) (IFC-ACS, 'plaque erosion'). Recent studies emphasize neutrophils as the immediate inflammatory response in this pathology, but their exact molecular activation patterns are still poorly understood and may represent future therapeutic targets.Thirty-two IFC-ACS matched ACS ruptured (RFC) (RFC-ACS) from OPTICO-ACS study were included, blood samples collected local site culprit...
Abstract Acute coronary syndrome (ACS) remains a major cause of worldwide mortality. The occurs when blood flow to the heart muscle is decreased or blocked, causing tissues die malfunction. There are three main types ACS: Non-ST-elevation myocardial infarction, ST-elevation and unstable angina. treatment depends on type ACS, this decided by combination clinical findings, such as electrocardiogram plasma biomarkers. Circulating cell-free DNA (ccfDNA) proposed an additional marker for ACS...
Low endothelial shear stress (ESS) and associated adverse biomechanical features stimulate inflammation, contribute to atherogenesis, predispose coronary plaque disruption. The mechanistic links between flow-related hemodynamics inflammatory mediators implicated in erosion, however, remain little explored. We investigated the relationship of high-risk ESS metrics culprit lesion proinflammatory/proatherogenic cells cytokines/chemokines erosion patients with acute syndromes. In eroded plaques,...
Abstract Left atrial appendage (LAA) closure is being developed as an alternative for stroke prevention in patients with fibrillation that cannot tolerate long-term oral anticoagulation. To assess the feasibility, safety, and performance of a novel modified Occlutech LAA device preclinical porcine model, Plus was implanted 12 female pigs (25–39 kg body weight) under fluoroscopic transesophageal echocardiography (TEE) guidance. Procedural technical success, well safety closure, were evaluated...
Rupture of the fibrous cap (RFC) represents main pathophysiological mechanism causing acute coronary syndromes (ACS). Destabilization due to plaque biomechanics is considered be importantly involved, exact mechanisms triggering ruptures are, however, unknown. This study aims at characterizing relation between components and rupture points ACS-causing culprit lesions in a large cohort ACS-patients assessed by high-resolution intracoronary imaging. Within prospective, multicentric OPTICO-ACS...
Inflammasomes are crucial gatekeepers of the immune response, but their maladaptive activation associates with inflammatory pathologies. Besides canonical activation, monocytes can trigger non-transcriptional or rapid inflammasome that has not been well defined in context acute myocardial infarction (AMI). Rapid transcription-independent induced by simultaneous TLR priming and triggering stimulus was measured caspase-1 (CASP1) activity interleukin release. Both classical intermediate from...
Abstract Aims Coronary microevaginations (CMEs) represent an outward bulge of coronary plaques and have been introduced as a sign adverse vascular remodelling following device implantation. However, their role in atherosclerosis plaque destabilization the absence intervention is unknown. This study aimed to investigate CME novel feature vulnerability characterize its associated inflammatory cell–vessel–wall interactions. Methods results A total 557 patients from translational OPTICO-ACS...
Abstract Background Sex and plaque histology are intertwined, with fibrous atherosclerotic plaques being more prevalent in women pointing to general smooth muscle cell plasticity estrogen signaling. Plaque erosion, a significant contributor acute coronary syndromes (ACSs), is linked as compared men. We hypothesize that the molecular drivers of histologically determined differ between men women. Methods Human end-stage were isolated from consecutive patients who underwent carotid...
Abstract Background Optical coherence tomography (OCT) has refined acute coronary syndrome (ACS)-management by enabling in-depth characterization of culprit lesions. Differentiating between plaques with ruptured (RFC) and intact fibrous cap (IFC) shaped clinical decision making. However, the systemic vascular changes associated different plaque morphologies remain unexplored. Purpose To investigate arterial stiffness among ACS-causing (RFC vs. IFC) its prognostic value post-ACS. Methods We...
Abstract Background Cell death during tissue injury leads to release of chromosomal DNA which is promptly degraded. However, short fragments wrapped around nucleosomes survive longer in the bloodstream and can be isolated as circulating cell-free (ccfDNA). Oncology field pioneered use cfDNA clinical biomarker by identifying sequence modifications induced cancer cells. Importantly, ccfDNA also retains same epigenetic information origin. Despite major advances for disease diagnosis therapy,...
Abstract Background Immune responses are intricately linked to human disease, not only during pathogenic infections but also in sterile injury events such as cardiovascular disease. Atherosclerosis is the main driver leading coronary artery disease (CAD) and subsequent development of acute myocardial infarction (AMI) heart failure. The vital role monocytes pathophysiology atherosclerosis well established. In onset AMI, act first responders, both inflammatory tissue repair phases. It now...
Abstract Acute coronary syndromes (ACS) remain a major cause of worldwide mortality. ACS diagnosis is done by combination factors, such as electrocardiogram and plasma biomarkers. These biomarkers, however, lack the power to accurately stratify patients into different risk groups. Instead, we used changes in circulating cell-free DNA (ccfDNA) methylation profiles estimate extent heart injury severity ACS. Our approach relies on fact that dying cells acutely damaged tissue release blood,...
Abstract Background Inflammation is a protective response triggered not only upon pathogen insults but also- in sterile injury as happening during hypoxic episodes acute myocardial infarction (AMI). Monocytes are among the first responder immune cells playing an important role inflammation induction also its timely resolution. Understanding mechanisms governing this two-sided modulation can help to uncover novel therapeutic approaches. Inflammasomes crucial gatekeepers of response, their...
Pathophysiology of coronary artery diseases 127duction (matching efficiency 95%, narterial group = 125, nvenous 250).In the arterial group, LAD was exclusively revascularized by using an graft, in venous a graft.The survival curves started to diverge complete cohort (Figure 1A) as well propensity score-matched 1B) five years after surgery.Survival significantly lower patients with revascularization (crude logRank p<0.001, p=0.043).There were no significant differences noted perioperative...
Abstract Background In up to one third of all cases, acute coronary syndrome occurs without signs plaque rupture. Instead endothelial cell erosion is considered be the hallmark with intact fibrous cap (IFC-ACS), matrix metalloproteinase 9 (MMP9) directly linked this pathology. The main source MMP9 immediately after ACS are neutrophil granulocytes. Therefore, their molecular activation patterns and subsequent production objectives ongoing, translational OPTICO-ACS-Study, aiming compare...
Abstract Background Neutrophil granulocytes are key players of the innate immunity, participating in initiation and progression atherosclerosis. However, exact mechanisms neutrophil activation after acute coronary syndrome (ACS) poorly understood, especially context two predominant ACS-causing pathophysiologies - ACS with intact fibrous cap (IFC-ACS) ruptured (RFC-ACS). Therefore, current study focuses on immunophenotyping ex-vivo functional characterization neutrophils regard to molecular...
Even with emerging evidence that the use of intracoronary imaging techniques can significantly support interventional procedure, during catheterization procedures still remains comparatively low. With help percutaneous coronary interventions be optimized and fundamental information about plaque morphology archived. This is not only beneficial in determining vulnerability but also assist approach complex lesions including calcified lesions, as well causing an acute syndrome. Especially...