A5113333727- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Advanced NMR Techniques and Applications
- Advanced X-ray and CT Imaging
- Cardiovascular Function and Risk Factors
- Medical Imaging Techniques and Applications
- Electron Spin Resonance Studies
- Atomic and Subatomic Physics Research
- Advanced Radiotherapy Techniques
- Ultrasound and Hyperthermia Applications
- Head and Neck Cancer Studies
- Surfactants and Colloidal Systems
- NMR spectroscopy and applications
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Effects of Radiation Exposure
- Cardiac Valve Diseases and Treatments
- Photoacoustic and Ultrasonic Imaging
- Infrared Thermography in Medicine
- Protein Interaction Studies and Fluorescence Analysis
- Cardiovascular Disease and Adiposity
- Ocular Oncology and Treatments
- Radiation Dose and Imaging
- Protein purification and stability
- Drilling and Well Engineering
Siemens Healthcare (Germany)
2020-2025
Hospital Universitario Quirónsalud Madrid
2024
General Electric (Spain)
2022-2024
University of Virginia
2024
Martin Luther University Halle-Wittenberg
2003-2023
General Electric (Germany)
2015-2023
Iwate Medical University
2022
University of Chicago
2020-2021
University of Illinois Chicago
2020-2021
General Electric (United States)
2013-2020
Abstract Metabolic imaging with hyperpolarized [1‐ 13 C]pyruvate offers the unique opportunity for a minimally invasive detection of cellular metabolism. Efficient and robust acquisition reconstruction techniques are required capturing wealth information present limited duration state (∼1 min). In this study, Dixon/IDEAL type water–fat separation is expanded toward spectroscopic its down‐stream metabolites. For purpose, spectral–spatial encoding based on single‐shot spiral image echo‐time...
Abstract Within the last decade hyperpolarized [1‐ 13 C] pyruvate chemical‐shift imaging has demonstrated impressive potential for metabolic MR a wide range of applications in oncology, cardiology, and neurology. In this work, highly efficient pulse sequence is described time‐resolved, multislice chemical shift injected substrate obtained downstream metabolites. Using spectral‐spatial excitation combination with single‐shot spiral data acquisition, overall encoding evenly distributed between...
Abstract Objectives The aim of this study was to assess the effect a deep learning (DL)–based reconstruction algorithm on late gadolinium enhancement (LGE) image quality and evaluate its influence scar quantification. Methods Sixty patients (46 ± 17 years, 50% male) with suspected or known cardiomyopathy underwent CMR. Short-axis LGE images were reconstructed using conventional DL network (DLRecon) tunable noise reduction (NR) levels from 0 100%. Image standard DLRecon 75% NR scored 5-point...
Abstract Background The aim of the present study was to evaluate recovery potential parotid glands after using either 3D-conformal-radiotherapy (3D-CRT) or intensity-modulated radiotherapy (IMRT) by sparing one single gland. Methods Between 06/2002 and 10/2008, 117 patients with head neck cancer were included in this prospective, non-randomised clinical study. All treated curative intent. Salivary gland function assessed measuring stimulated salivary flow at beginning, during end as well 1,...
Magnetic Resonance Imaging has become nowadays an indispensable tool with applications ranging from medicine to material science.However, so far the physical limits of maximum achievable experimental contrast were unknown.We introduce approach based on principles optimal control theory explore these limits, providing a benchmark for numerically optimized robust pulse sequences which can take into account imperfections.This is demonstrated experimentally using model system two spatially...
Hyperpolarization of [1-13C]pyruvate in solution allows real-time measurement uptake and metabolism using MR spectroscopic methods. After injection perfusion, pyruvate is taken up by the cells enzymatically metabolized into downstream metabolites such as lactate, alanine, bicarbonate. In this work, we present comprehensive methods for quantification interpretation hyperpolarized 13C metabolite signals. First, a time-domain spectral fitting method described decomposition FID signals their...
Two-dimensional (2D) cine imaging is essential in routine clinical cardiac MR (CMR) exams for assessing structure and function. Traditional requires patients to hold their breath extended periods maintain consistent heartbeats optimal image quality, which can be challenging those with impaired breath-holding capacity or irregular heart rhythms. This study aims systematically assess the performance of a deep learning-based reconstruction (Sonic DL Cine, GE HealthCare, Waukesha, WI, USA)...
Abstract Transmit gain ( B ) calibration is necessary for the adjustment of radiofrequency (RF) power levels to desired flip angles. In proton MRI, this generally an automated process before actual scan without any user interaction. For other nuclei, it usually time consuming and difficult, especially in case hyperpolarised MR. current work, transmit was implemented on basis Bloch–Siegert phase shift. From same data, centre frequency, line broadening SNR could also be determined. The T 1 0...
Purpose Because pH plays a crucial role in several diseases, it is desirable to measure vivo noninvasively and spatially localized manner. Spatial maps of were quantified vitro, with focus on method‐based errors, applied vivo. Methods In vitro 13 C mapping performed for various flip angles bicarbonate (BiC) CO 2 spectral‐spatial excitation spiral readout healthy Lewis rats five slices. Acute subcutaneous sterile inflammation was induced Concanavalin A the right leg Buffalo rats. proton...
Purpose Total scalp irradiation (TSI) is a rare but challenging indication. We previously reported that non-coplanar intensity-modulated radiotherapy (IMRT) was superior to coplanar IMRT in organ-at-risk (OAR) protection and target dose distribution. This consecutive treatment planning study compared with volumetric-modulated arc therapy (VMAT). Materials Methods A retrospective plan databank search performed 5 patient cases were randomly selected. Cranial imaging restored from the initial...
Abnormalities of tumor metabolism can be exploited for molecular imaging. PET imaging <sup>18</sup>F-FDG is a well-established method using the avid glucose uptake cells. <sup>13</sup>C MR spectroscopic (MRSI) hyperpolarized [1-<sup>13</sup>C]pyruvate and its metabolites, meanwhile, represents new to study energy by visualizing, example, augmented lactate dehydrogenase activity in Because rapid signal loss, this underlies strict temporal limitations, acquisition data—encoding spatial,...
Individual tumor characterization and treatment response monitoring based on current medical imaging methods remain challenging. This work investigates hyperpolarized 13C compounds in an orthotopic rat hepatocellular carcinoma (HCC) model system before after transcatheter arterial embolization (TAE). HCC ranks amongst the top six most common cancer types humans accounts for one-third of cancer-related deaths worldwide. Early therapy could aid development personalized approaches novel...
The combination of hyperpolarized MRS with diffusion weighting (dw) allows for determination the apparent coefficient (ADC), which is indicative intra- or extracellular localization metabolite. Here, a slice-selective pulsed-gradient spin echo sequence was implemented to acquire series dw spectra from rat muscle in vivo determine ADCs multiple metabolites after single injection [1-13C]pyruvate. An optimal control optimized universal-rotation pulse used refocusing minimize signal loss caused...
Severe COVID-19 infection is known to alter myocardial perfusion through its effects on the endothelium and microvasculature. However, majority of patients with experience only mild symptoms, it unknown if their altered after infection. The authors aimed determine there are abnormalities in blood flow (MBF), as measured by stress cardiac magnetic resonance (CMR), individuals a We conducted prospective, comparative study who had prior (n = 30) matched controls 26) using CMR. Stress rest...