A5073494537- Autism Spectrum Disorder Research
- Family and Disability Support Research
- Child Nutrition and Feeding Issues
- Birth, Development, and Health
- Growth Hormone and Insulin-like Growth Factors
- Child and Adolescent Psychosocial and Emotional Development
- Estrogen and related hormone effects
- Gestational Diabetes Research and Management
- Infant Development and Preterm Care
- Adolescent and Pediatric Healthcare
- Child Development and Digital Technology
- Obesity, Physical Activity, Diet
- Genetic Syndromes and Imprinting
- Pregnancy and preeclampsia studies
- Genetics and Neurodevelopmental Disorders
- Adrenal Hormones and Disorders
- Vaccine Coverage and Hesitancy
- Child and Adolescent Health
- Bipolar Disorder and Treatment
- Congenital heart defects research
- Adipokines, Inflammation, and Metabolic Diseases
- Genomic variations and chromosomal abnormalities
- Family Support in Illness
- Lipid metabolism and disorders
- Maternal Mental Health During Pregnancy and Postpartum
Parnassia Groep
2016-2025
Codarts Rotterdam
2023-2025
Parnassia Groep Academie
2025
Leiden University Medical Center
2019-2024
Leiden University
2020-2021
Columbia University
2016-2018
Berkeley Public Health Division
2017
Public Health Institute
2017
University Medical Center Freiburg
2017
University of Freiburg
2017
Summary objective Sensitivity to glucocorticoids differs between individuals, partially due genetic variation in the glucocorticoid receptor (GR) gene. We studied sequence alteration of a previously described intronic Bcl I polymorphism GR gene, and investigated whether there was an association with sensitivity anthropometric parameters group healthy elderly individuals. design measurements In study 1, two overnight dexamethasone suppression tests (DSTs) were performed: 1 mg dexamethasone,...
Abstract Glucocorticoid receptor (GR) gene expression is regulated in a complex tissue-specific manner, notably by early-life environmental events that program tissue GR levels. We have identified and characterized several new rat mRNAs. All encode common protein, but differ their 5′-leader sequences as consequence of alternate splicing of, potentially, 11 different exon 1 sequences. Most are located 3-kb CpG island, upstream 2, exhibits substantial promoter activity transfected cells....
Small for gestational age (SGA)-born children comprise a heterogeneous group in which only few genetic causes have been identified.To determine copy number variations 18 growth-related genes 100 SGA with persistent short stature.Copy (SHOX, GH1, GHR, IGF1, IGF1R, IGF2, IGFBP1-6, NSD1, GRB10, STAT5B, ALS, SOCS2, and SOCS3) were determined by an "in house" multiplex ligation-dependent probe amplification kit. The deletions further characterized single-nucleotide polymorphism array analysis.Two...
Risperidone is the most commonly prescribed antipsychotic drug to children and adolescents worldwide, but it associated with serious side effects, including weight gain. This study assessed relationship of risperidone 9-hydroxyrisperidone trough concentrations, maximum concentrations 24-hour area under curves (AUCs) body mass index (BMI) z-scores in autism spectrum disorder (ASD) behavioural problems. Secondary outcomes were metabolic, endocrine, extrapyramidal cardiac effects...
Parents of children with ASD are at risk for chronic stress due to challenging parenting. It is unknown whether already present in early parenthood, similar mothers and fathers if this impacts quality life (QoL). Parental QoL were assessed 56 51 young (aged 3 7) autism. Associations between parental (OBVL) (WHOQoL-BREF) examined. appear have high from conflicting feelings towards their child difficulties Mothers higher feeling confined motherly role than compared the OBVL norm population....
Abstract Obesity is present in 8–32% of the children with Autism Spectrum Disorder (ASD). However, most studies are performed school-aged from USA. The current study compares obesity rates Dutch preschoolers ASD general population and explores which child- parental factors related to ASD. This cross-sectional part ongoing Tandem Study (Dutch Trial register: NL7534). Seventy-eight aged 3–7 years their parents (77 mothers, 67 fathers) participated. Child are: Body Mass Index (by physical...
Abstract Children with autism and their parents face daily challenges that may be stressful for both. However, little is known about biological stress (hair cortisol concentrations [HCC]) in these families its connection to children’s health outcomes. This study investigates children associations child mental health, eating behavior BMI. Stress was measured 102 young (101 mothers, 86 fathers) using HCC self-reported parenting (OBVL). Child through symptoms (ADOS-2, SRS-2) problem (CBCL)....
Purpose The lasting impact of the COVID-19 pandemic on autistic children and adolescents remains uncertain. Disruptions to routines, social communication support systems presented unique challenges. existing body research has produced inconclusive results, necessitating further investigation elucidate this ambiguity. This study aims provide clarity regarding emotional behavioral functioning youth in response related lockdowns. We explore distinct subgroups Autism Spectrum Disorder (ASD),...
Resilience within families may temper the risk of high parenting stress faced by parents young children with ASD. Within families, individual differences between contribute differently to resilience. There is a lack in knowledge regarding contribution intrapersonal and contextual factors associated resilience ASD same family. In this cross-sectional study (n=249 individuals), addressed investigating (1) family stress, (2) contributing maternal (n=87) paternal (n=74) resilience, (3) relating...
The COVID-19 pandemic is a challenge for everyone, particularly children and adolescents with autism spectrum disorder (ASD). ASD developmental characterised by limitations in social communication, repetitive behavioural patterns, limited interests, activities. It expected that many families will experience more problems due to the related public health restrictions. At same time, some may improved functioning, fewer expectations demands. In mixed-method study identify impact of pandemic,...
BackgroundPeople who give care to autistic individuals (autism-caregivers) experience higher levels of caregiver strain than people provide for with other chronic conditions (non-autism-caregivers). This places them at risk psychological, behavioural and physical health concerns. The aim this study is delineate behavioural, aspects in autism-caregivers compared non-autism-caregivers.MethodsWe included 3354 adult caregivers from the general population Netherlands participating second...
Abstract Professionals’ limited knowledge on mental health and their stigmatizing attitudes toward illness can delay the diagnosis of autism. We evaluated Autism Spectrum Disorder (ASD) in 93 physicians at Dutch Youth Family Centers (YFC). These screen for psychiatric symptoms children. show that general ASD scored 7.1 (SD 1.2), but specific was only 5.7 1.7) (weighted means 1–10 scale, 1 = least knowledge, 10 most knowledge). Our had positive (CAMI scores 2.18 0.33) to 2.22 0.40) a 5-point...
The polymorphic deletion of exon 3 the GH receptor (d3-GHR) has recently been linked to magnitude growth response recombinant human (rhGH) therapy in short children with or without deficiency. We investigated this association a large multinational cohort from Network European Studies Genes Growth (NESTEGG), comprising born small for gestational age (SGA).The study included prepubertal SGA treated rhGH 1 2 years.Two hundred and forty white Caucasian (138 male, 102 female) aged 6.6 +/- 2.3...
Abstract Mothers of children with Autism Spectrum Disorder (ASD) often experience chronic stress and are at risk for adverse health. However, little is known about fathers, especially when their child in early childhood. Parenting stress, eating behavior physical health was evaluated mothers (n = 48) fathers 43) young (3–7 years) ASD by questionnaires measurements. Mother’s prevalence rates obesity (39.1%), abdominal (59.6%) metabolic syndrome (21.6%) were higher than the norm. In rate...
We determined whether subclassification of short small for gestational age (SGA) children according to birth anthropometrics could delineate different patterns in gestation, delivery, postnatal growth, response growth hormone (GH) treatment and parental height.201 SGA were divided into three groups, SGA(L), SGA(L+W) SGA(L+W+HC), length (L), weight (W) head circumference (HC) < or =-2.00 standard deviation score (SDS).SGA(L+W+HC) born after the shortest more often by caesarean section than...
IGF binding protein (IGFBP)-1 is the only acute regulator of IGF-I bioavailability. Its production suppressed by insulin, and low levels are associated with hyperinsulinemia cardiovascular disease risk in adults. Data on IGFBP-1 short, small for gestational age (SGA) subjects scarce, associations IGFBP1 promoter single nucleotide polymorphisms have not been established.The aim study was to determine short SGA compared those controls, assess genotype frequency -575 G/A polymorphism, its...