A5022035980- Tendon Structure and Treatment
- Shoulder Injury and Treatment
- Sports injuries and prevention
- Advanced Graph Theory Research
- Orthopedic Surgery and Rehabilitation
- Limits and Structures in Graph Theory
- Bee Products Chemical Analysis
- Myofascial pain diagnosis and treatment
- Constraint Satisfaction and Optimization
- Exercise and Physiological Responses
- Veterinary Equine Medical Research
- Sports Performance and Training
- Complexity and Algorithms in Graphs
- Graph Labeling and Dimension Problems
- Graph theory and applications
- Cellular Mechanics and Interactions
- Lower Extremity Biomechanics and Pathologies
- Recycling and Waste Management Techniques
- Biotechnology and Related Fields
- Foot and Ankle Surgery
- Musculoskeletal pain and rehabilitation
- semigroups and automata theory
- Lipid metabolism and disorders
- Knee injuries and reconstruction techniques
- Algorithms and Data Compression
Vancouver Coastal Health
2015-2025
University of British Columbia
2016-2025
Vancouver Coastal Health Research Institute
2014-2025
University of Oxford
2014-2024
University of Sheffield
2007-2021
Washington University in St. Louis
2021
University of British Columbia Hospital
2014-2019
Hispanics in Philanthropy
2019
Providence Health Care
2019
Sutter Health
2019
Persistent tendon pain that impairs function has inconsistent medical terms can influence choice of treatment.1 When a person is told they have tendinopathy by clinician A or tendinitis B, might feel confused be alarmed at receiving what perceive as two different diagnoses. This may lead to loss confidence in their health professional and likely adds uncertainty if were search for information about condition. Clear uniform terminology also assists inter-professional communication....
ABSTRACT: Dystonic torticollis has been treated with local injections of botulinum toxin in a single blind study 12 patients. A significant decrease abnormal movements was recorded, and pain improved. Further studies are desirable to define the optimum dosage site for injections, long term effects repeated injections.
To investigate tenocyte regulatory events during the development of overuse supraspinatus tendinosis in rats.Supraspinatus was induced by running rats downhill at 1 km/hour for hour a day. Tendons were harvested 4, 8, 12, and 16 weeks processed brightfield, polarized light, or transmission electron microscopy. The assessed semiquantitatively using modified Bonar histopathologic scale. Apoptosis proliferation examined antibodies against fragmented DNA proliferating cell nuclear antigen,...
The pathogenesis of tendon overuse injuries is poorly understood. histopathology underlying tendinopathy at various anatomical locations similar and may reflect a common pathologic process.Apoptosis contributes to the pathophysiology in patellar tendinopathy.Case control study; Level evidence, 3.We compared biopsy specimens from patients with diagnosed clinically typical magnetic resonance image findings group without any previous or current knee complaints suggest tendinopathy. presence...
A small number of randomized controlled trials have found ultrasound-guided injection platelet-rich plasma (PRP) to be no more effective than saline for several tendinopathies; limited information exists patellar tendinopathy. In addition, different PRP formulations that produce varying concentrations leukocytes not been directly compared tendinopathy.To determine if a single injection, either leukocyte-rich (LR-PRP) or leukocyte-poor (LP-PRP), was superior the treatment The null hypothesis...
Background The absence of any agreed-upon tendon health-related domains hampers advances in clinical tendinopathy research. This void means that researchers report a very wide range outcome measures inconsistently. As result, substantial synthesis/meta-analysis research findings is almost futile despite publishing busily. We aimed to determine options for, and then define, core for tendinopathy. Methods conducted Delphi study healthcare professionals (HCP) patients three-stage process. In...
Achieving functional restoration of diseased or injured tissues is the ultimate goal both regenerative medicine approaches and physical therapy interventions. Proper integration healing surrogate cells, tissues, organs introduced using techniques are often dependent on co-introduction therapeutic stimuli. Thus, rehabilitation represents a collaborative approach whereby specialists, basic scientists, physicians, surgeons work closely to enhance tissue by creating tailored treatments. One...
Inflammation, a term coined by the ancients, is widely used in sports medicine. But what meant when clinician tells patient that symptoms are probably due to inflammation? The question of whether inflammation helpful or harmful healing can only be answered after defined. This brief analysis reveals term’s definition has changed dramatically since it was first Celsus nearly 2000 years ago. also depends on type lens viewer using—whether clinical, cellular, molecular.
The role of apoptosis, or programmed cell death, has only recently been explored in tendon.To investigate the development apoptosis after high strain loading rat tendon.The right tibialis anterior tendons three rats were prepared for mechanical loading, and left identically as non-loaded controls. Tendon was loaded with 20% six hours using a 1 Hz longitudinal sine wave signal. following used to assess apoptosis: (a) monoclonal mouse antibody (F7-26) label single stranded DNA breaks; (b)...
Objective To determine whether there are objective findings of tendinosis in a rabbit tendinopathy model on exercised and contralateral (non-exercised) Achilles tendons. Design Four groups six New Zealand white rabbits per group were used. The animals one (control) not subjected to exercise/stimulation. Interventions Animals protocol electrical stimulation passive flexion–extension the right triceps surae muscle every second day for 1, 3 or 6 weeks. Main Outcome Measures Tenocyte number...
Tenocytes produce substance P (SP), and its receptor (neurokinin-1 (NK-1R)) is expressed throughout the tendon tissue, especially in patients with tendinopathy tissue changes (tendinosis) including hypercellularity vascular proliferation. Considering known effects of SP, one might ask whether SP contributes to these changes.To test development tendinosis-like (hypercellularity angiogenesis) accelerated during a 1-week course exercise local administration an established Achilles model.Rabbits...
Being overweight or obese is associated with an elevated risk of tendon pathology. However, for sportspeople the epidemiological data linking weight adiposity on one hand, and pathology other, are less consistent. Indeed, mechanistic links between diet, remain largely unexamined. Recent studies have begun to examine effects dietary interventions outcomes such as biomechanics pain. Oxidised low-density lipoprotein has been shown (A) accumulate in tissues mice that eat a fatty diet (B) induce...
We aimed to establish consensus for reporting recommendations relating participant characteristics in tendon research. A scoping literature review of tendinopathy studies (Achilles, patellar, hamstring, gluteal and elbow) was followed by an online survey face-to-face meeting with expert healthcare professionals (HCPs) at the International Scientific Tendon Symposium, Groningen 2018. reviewed 263 papers form statements invited 30 HCPs from different disciplines geographical locations; 28...
Tendons are specialized tissues composed primarily of load-responsive fibroblasts (tenocytes) embedded in a collagen-rich extracellular matrix. Habitual mechanical loading or targeted exercise causes tendon cells to increase the stiffness matrix; this adaptation may occur part through collagen synthesis remodeling. Integrins likely play an important role transmitting stimuli from matrix cells, thereby triggering cell signaling pathways which lead adaptive regulation mRNA translation and...