A5086097329- Tendon Structure and Treatment
- Shoulder Injury and Treatment
- Sports injuries and prevention
- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Myofascial pain diagnosis and treatment
- Orthopedic Surgery and Rehabilitation
- Plant Micronutrient Interactions and Effects
- Autoimmune and Inflammatory Disorders Research
- Plant nutrient uptake and metabolism
- Forecasting Techniques and Applications
- Psoriasis: Treatment and Pathogenesis
- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Lymphoma Diagnosis and Treatment
- Aging, Health, and Disability
- Plant Stress Responses and Tolerance
- Musculoskeletal synovial abnormalities and treatments
- Osteoarthritis Treatment and Mechanisms
- Inflammasome and immune disorders
- Legume Nitrogen Fixing Symbiosis
- Health Systems, Economic Evaluations, Quality of Life
- Simulation Techniques and Applications
- Vasculitis and related conditions
- Asthma and respiratory diseases
Cambridge University Hospitals NHS Foundation Trust
2013-2019
Center for Health, Exercise and Sport Sciences
2019
Fortius Clinic
2019
Queen Mary University of London
2019
Addenbrooke's Hospital
2013-2016
University of Cambridge
2016
St Peter's Hospital
2014
St George's, University of London
2014
Guy's and St Thomas' NHS Foundation Trust
2011-2012
Rolls-Royce (United Kingdom)
2012
Overuse disorders of tendons, or tendinopathies, present a challenge to sports physicians, surgeons, and other health care professionals dealing with athletes. The Achilles, patellar, supraspinatus tendons are particularly vulnerable injury often difficult manage successfully. Inflammation was believed central the pathologic process, but histopathologic evidence has confirmed failed healing response nature these conditions. Excessive inappropriate loading musculotendinous unit is be disease...
Persistent tendon pain that impairs function has inconsistent medical terms can influence choice of treatment.1 When a person is told they have tendinopathy by clinician A or tendinitis B, might feel confused be alarmed at receiving what perceive as two different diagnoses. This may lead to loss confidence in their health professional and likely adds uncertainty if were search for information about condition. Clear uniform terminology also assists inter-professional communication....
Abstract Plants that hyperaccumulate Ni exhibit an exceptional degree of tolerance and the ability to translocate in large amounts from root shoot. In hyperaccumulator plants genus Alyssum, free His is important binding ligand increases xylem proportionately uptake. To determine molecular basis response its contribution tolerance, transcripts representing seven eight enzymes involved biosynthesis were investigated species Alyssum lesbiacum by RNA gel blot analysis. None changed abundance...
Degenerative disorders of tendons present an enormous clinical challenge. They are extremely common, prone to recur and existing medical surgical treatments generally unsatisfactory. Recently eccentric, but not concentric, exercises have been shown be highly effective in managing tendinopathy the Achilles (and other) tendons. The mechanism for efficacy these is unknown although it has speculated that forces generated during eccentric loading a greater magnitude. Our objective was determine...
Background The absence of any agreed-upon tendon health-related domains hampers advances in clinical tendinopathy research. This void means that researchers report a very wide range outcome measures inconsistently. As result, substantial synthesis/meta-analysis research findings is almost futile despite publishing busily. We aimed to determine options for, and then define, core for tendinopathy. Methods conducted Delphi study healthcare professionals (HCP) patients three-stage process. In...
We aimed to establish consensus for reporting recommendations relating participant characteristics in tendon research. A scoping literature review of tendinopathy studies (Achilles, patellar, hamstring, gluteal and elbow) was followed by an online survey face-to-face meeting with expert healthcare professionals (HCPs) at the International Scientific Tendon Symposium, Groningen 2018. reviewed 263 papers form statements invited 30 HCPs from different disciplines geographical locations; 28...
The antiphospholipid (APS or Hughes') syndrome, anticardiolipin antibodies (aCL), and the lupus anticoagulant (LA) are associated with systemic erythematosus, malignancy, infection, drugs. It has been described in patients primary vasculitis (PSV).To determine prevalence of APS PSV attending a clinic positive aCL and/or LA who do not fulfil classification criteria for APS.All case notes over 12 month period were reviewed. Outpatients inpatients both included assessed features presence aPL....
Summary Despite the functional importance of histidine (His) as an essential amino acid in proteins and a metal‐coordinating ligand, comparatively little is known about regulation its biosynthesis plants potential for metabolic engineering this pathway. To investigate contribution different steps pathway to overall control His biosynthesis, nine biosynthetic genes were individually over‐expressed Arabidopsis thaliana determine their effects on free pools. Constitutive, CaMV 35S ‐driven...
Introduction There is a general belief that the pathology of patellar tendon limited to proximal pole, however this has not been studied in detail. This unfortunate since location within tendon, or supporting structure(s), should be considered when designing treatment programme. lack clarity led different definitions tendinopathy being used studies physical rehabilitation. The Defence Medical Rehabilitation Centre at Headley Court provides diagnosis and musculoskeletal rehabilitation for...
In today's volatile environment, controlling the cost of ownership and maximizing operational capability are both critical to sustainability systems. long history services management delivered by Rolls-Royce, RAMS (Reliability, Availability, Maintainability, Safety) has remained a key principle for service delivery we have worked evolve infrastructure tailored deliver responsiveness foresight demanded customers. Contracts Rolls-Royce like TotalCare®, CorporateCare® MissionCare™ essentially...
Inflammatory arthritis is a significant cause of morbidity in the military. In particular sero-negative spondyloarthritides, which include ankylosing spondylitis, psoriatic arthritis, reactive inflammatory bowel disease related and undifferentiated spondyloarthritis, are especially prevalent young male phenotype, common Armed Forces. It estimated that there more than 1500 patients Forces with spondyloarthritis alone, based on prevalence general population approximately 1%. arthritides...
The British military has a cohort of patients with ankylosing spondylitis (AS) characterised by young age and short disease duration. Many the most severely affected AS have been treated since 2005 at Headley Court anti-tumour necrosis factor (anti-TNF) therapy in accordance National Institute Health Care Excellence guidance. We wanted to prospectively determine both safety efficacy this new treatment our population compare relevant civilian study outcome data.All commenced on anti-TNF were...
Background: Rheumatoid arthritis (RA) causes progressive joint damage and functional disability. Studies on factors affecting as clinical outcome are lacking in Africa. The aim of the present study was to identify predictors adult South Africans with established RA.
Results: Of the 43 patients, 7 had vasculitis (4 Wegener's granulomatosis; 1 Churg-Strauss syndrome; pulmonary-renal syndrome and crescentic glomerulonephritis).Of 67 patients with non vasculitis, 53 Respiratory presentations (30 pneumonia; 8 malignancy; 5 pulmonary embolism; 2 tuberculosis miscellaneous).11 Renal (7 acute renal failure/acute tubular necrosis 4 miscellaneous).3 Pulmonary-renal (pneumonia (2)/brochiectasis (1) impairment).The table shows median number of BVAS items systems...