A5072101703- Pharmaceutical studies and practices
- Pulmonary Hypertension Research and Treatments
- Congenital Heart Disease Studies
- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects and Toxicity Studies
- Pediatric Pain Management Techniques
- Neonatal Respiratory Health Research
- Epilepsy research and treatment
- Cardiovascular Issues in Pregnancy
- Blood disorders and treatments
- Antibiotics Pharmacokinetics and Efficacy
- Anesthesia and Sedative Agents
- Ion channel regulation and function
- Heart Failure Treatment and Management
- Health Systems, Economic Evaluations, Quality of Life
- Asthma and respiratory diseases
- Cardiac Arrhythmias and Treatments
- Drug Transport and Resistance Mechanisms
- Kawasaki Disease and Coronary Complications
- Health and Medical Studies
- Adolescent and Pediatric Healthcare
- Pharmaceutical Economics and Policy
- Childhood Cancer Survivors' Quality of Life
- Coronary Artery Anomalies
- Venous Thromboembolism Diagnosis and Management
Heidelberg University
2015-2025
University Hospital Heidelberg
2015-2025
University of Basel
2017-2024
University Children’s Hospital Basel
2017-2024
Uniwersytecki Szpital Dziecięcy
2020-2024
Children's Clinical University Hospital
2020-2024
Sechenov University
2024
Zentrum für Kinderheilkunde
2021-2022
Temple Street Children's University Hospital
2020
Children's National
2015-2017
Background: The aim of the study was to document cardiovascular clinical findings, cardiac imaging, and laboratory markers in children presenting with novel multisystem inflammatory syndrome associated coronavirus disease 2019 (COVID-19) infection. Methods: This real-time internet-based survey has been endorsed by Association for European Paediatric Congenital Cardiologists Working Groups Cardiac Imaging Cardiovascular Intensive Care. Children 0 18 years age admitted a hospital between...
Fentanyl is primarily metabolized by CYP3A, but has also been suggested to act as a weak inhibitor of CYP3A. We investigated the influence CYP3A inhibition ketoconazole on pharmacokinetics intravenously administered fentanyl and effect activity. A prospective, open-label, randomized, monocentre, crossover study was conducted in 16 healthy volunteers. They received alone (5 microgram per kilogram) or plus (200 milligram orally B.I.D. over 2 days). Naloxone (2 × 0.2 i.v.) given simultaneously...
Therapeutic management of epilepsy remains a challenge, since optimal systemic antiseizure medication (ASM) concentrations do not always correlate with improved clinical outcome and minimal side effects. We tested the feasibility noninvasive real-time breath metabolomics as an extension traditional therapeutic drug monitoring for patient stratification by simultaneously drug-related drug-modulated metabolites.This proof-of-principle observational study involved 93 measurements 54 paediatric...
Background and Clinical Significance: We report on an infant with Snijders Blok–Campeau syndrome (psychomotor developmental delay, CNS malformations) a complex heart defect pulmonary arterial hypertension. Case Presentation: A DDX3X mutation encoding for RNA helicase was detected, which may suggest association between the development of vasculopathy. However, further validation is required. Conclusions: important role in vasculature.
Background: The aim of the study was to document cardiovascular clinical findings, cardiac imaging and laboratory markers in children presenting with novel multisystemic inflammatory syndrome associated COVID-19. Methods: A real-time internet based survey sent via member mailing database for Association European Paediatric Congenital Cardiologists (AEPC) working groups Cardiac Imaging Cardiovascular Intensive Care member. Inclusion criteria 0-18 years admitted hospital between March 1 June...
Trends in shortages of vaccines and immune globulin products from 2001 through 2015 the United States are described.Drug shortage data January December were obtained University Utah Drug Information Service. Shortage for globulins analyzed, focusing on type product, reason shortage, duration, requiring vaccine deferral, whether drug was a single-source product. Inclusion product into pediatric vaccination schedule also noted.Of 2,080 reported shortages, 59 (2.8%) products. Of those, 2 (3%)...
To describe US drug shortages affecting medications on the 2019 World Health Organization (WHO) Model List of Essential Medicines for Children (EMLc).Drug shortage data from January 2014 to December were obtained University Utah Drug Information Service. Shortage drugs EMLc analyzed type drug, American Hospital Formulary Service category, reason shortage, duration marketing status (generic vs brand name), and whether agent was a single- or multisource drug.From 2019, total 209 impacted EMLc,...
Clinical studies in children are necessary yet conducting multiple visits at study centers remains challenging. The success of "care-at-home" initiatives and remote clinical trials suggests their potential to facilitate conduct pediatric studies. This pilot aimed the feasibility remotely collecting valid (i.e. complete correct) saliva samples data utilizing mobile technology. Single-center, prospective undergoing elective tonsillectomy University Basel Children's Hospital. Data on pain...
Abstract OBJECTIVES The objective of the study was to improve postoperative risk assessment in congenital heart surgery by developing a machine-learning model based on readily available peri- and parameters. METHODS Our bicentric retrospective data analysis from January 2014 December 2019 established parameters for dismal outcome used train test predict survival within first 30 days. Freiburg training consisted 780 procedures; Heidelberg comprised 985 procedures. STAT mortality score, age,...
<b><i>Background:</i></b> Prescription drug shortages have increased significantly during the past two decades and also impact drugs used in critical care pediatrics. <b><i>Objectives:</i></b> To analyze affecting medications neonatal intensive units (NICUs). <b><i>Methods:</i></b> Drug shortage data for top 100 NICU were retrieved from University of Utah Information Service 2001 to 2016. Data analyzed focusing on class,...
A recent study investigating the pharmacokinetics of fentanyl in Sprague-Dawley rats suggested to be a substrate rat organic anion-transporting polypeptide Oatp. In human beings, most important OATP for many drugs is OATP1B1. Therefore, genetic variants OATP1B1 (SLCO1B1) might modulate and efficacy beings. Sixteen healthy male female volunteers, homozygous SLCO1B1*1a (genetic wild-type) (n = 11) or *15 (deficient haplotype carrying single-nucleotide polymorphisms rs2306283 rs4149056...