A5006189053- Forensic Toxicology and Drug Analysis
- Cannabis and Cannabinoid Research
- Alcohol Consumption and Health Effects
- Poisoning and overdose treatments
- Psychedelics and Drug Studies
- Pharmacogenetics and Drug Metabolism
- Neurotransmitter Receptor Influence on Behavior
- Metabolomics and Mass Spectrometry Studies
- Hormonal and reproductive studies
- Advancements in Transdermal Drug Delivery
- Attention Deficit Hyperactivity Disorder
- Pharmacology and Obesity Treatment
- Dermatology and Skin Diseases
- Pain Management and Opioid Use
- Pain Mechanisms and Treatments
- Hair Growth and Disorders
- Analytical Methods in Pharmaceuticals
- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Renal function and acid-base balance
- Opioid Use Disorder Treatment
- Analytical Chemistry and Chromatography
- Pharmaceutical studies and practices
- Antibiotics Pharmacokinetics and Efficacy
- Anesthesia and Sedative Agents
Supply Chain Competence Center (Germany)
2021-2024
Bayer (Germany)
2017-2022
München Klinik
2018-2021
University Hospital Heidelberg
2009-2019
Heidelberg University
2009-2019
University of Cologne
2018
Universität Hamburg
2018
University Medical Center Hamburg-Eppendorf
2018
Medizinische Hochschule Hannover
2018
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2016
The acute and chronic effects of dronabinol [medicinal Δ(9) -tetrahydrocannabinol (THC)] on actual driving performance the Standard Field Sobriety Test (SFST) were assessed. It was hypothesized that occasional users would be impaired these tests heavy show less impairment due to tolerance.Double-blind, placebo-controlled, randomized, three-way cross-over study. Twelve 12 cannabis (14 males/10 females) received single doses placebo, 10 20 mg dronabinol.Standard deviation lateral position...
The kinetic profile of ethanol and ethyl glucuronide (EtG) in serum was investigated three subject groups: 1) Healthy, moderately drinking volunteers (daily intake less than 30 g ethanol) who ingested a single dose ethanol. In this group the maximum concentration (SEtGC) (SEC) did not exceed 3.7 mg/L 1.5 g/L respectively. EtG peaked 2 to 3.5 h later eliminated with terminal half-life 3 h. decreased slower ethanol--the metabolite could still be determined up 8 after complete elimination. 2)...
The use of dried blood spots (DBS) which has successfully been introduced in neonatal metabolic screening is an appropriate method to reduce virus infection risk a minimum, facilitating regular mailing and handling samples the laboratory. Injection diacetylmorphine notably associated with prevalence transmission blood-borne viruses. aim present study was establish determine morphine 6-acetylmorphine (6-AM) as accurately sensitively from DBS whole blood. Analysis by liquid...
Ethyl glucuronide (EtG) is considered to be a promising candidate marker of alcohol consumption, but exhibits short window detection in blood or urine. Keratinized tissues are known retain foreign substances and provide greater retrospective than body fluids. Therefore, post-mortem hair, skin swabs, stratum corneum samples were collected from four subjects with reported history misuse seven report regular, socially accepted drinking behaviour, investigated for EtG. Additionally, certain...
The present study was designed to determine the stability of morphine and its glucuronides in spiked fresh blood plasma from live individuals as well four authentic postmortem specimens for a time interval up six months. samples were stored glass vials at −20°C, 4°C, 20°C. Additionally, exposed light through window subjected forced-degradation 40°C. Data established using solid-phase extraction high-performance liquid chromatography coupled atmospheric pressure ionization mass spectrometry...
Abstract A new validated method for the quantitation of abnormal phospholipid phosphatidylethanol (PEth)—a biomarker ethanol uptake—has been developed by LC‐ESI‐MS/MS following miniaturised organic solvent extraction and reversed phase chromatography with phosphatidylbutanol (PBut) as internal standard. PEth homologues two fatty acid substituents—PEth 18 : 1/18 1, 16 0/16 0—were determined in post‐mortem blood collected from heavy drinkers at autopsy also whole samples a volunteer after...
Journal Article Morphine and Glucuronides in Serum of Heroin Consumers Heroin-Related Deaths Determined by HPLC with Native Fluorescence Detection Get access Rolf Aderjan, Aderjan Institut für Rechtsmedizin im Klinikum, University Heidelberg, Vosstrasse 2, D-69115 Germany Search for other works this author on: Oxford Academic PubMed Google Scholar Sybille Hofmann, Hofmann Georg Schmitt, Schmitt Gisela Skopp Analytical Toxicology, Volume 19, Issue 3, May-June 1995, Pages 163–168,...
An increasing number of fatal road-accidents have been reported in which ecstasy was found the blood drivers. Although, is frequently to used combination with alcohol, studies on acute effects co-administered alcohol driving performance are relatively rare. The present study designed establish extent driver impairment as a consequence or combined and use compared under influence 0.3‰, 0.5‰ 0.8‰ alcohol. Furthermore, subjective also assessed. Alcohol mainly influenced automated such lateral...
Fentanyl is primarily metabolized by CYP3A, but has also been suggested to act as a weak inhibitor of CYP3A. We investigated the influence CYP3A inhibition ketoconazole on pharmacokinetics intravenously administered fentanyl and effect activity. A prospective, open-label, randomized, monocentre, crossover study was conducted in 16 healthy volunteers. They received alone (5 microgram per kilogram) or plus (200 milligram orally B.I.D. over 2 days). Naloxone (2 × 0.2 i.v.) given simultaneously...
Abstract Background: Unconjugated 11-nor-Δ9-carboxy-tetrahydrocannabinol (THCCOOH) in blood and urine has been proposed as a valuable marker, but the glucuronide (THCCOOglu) is present considerably higher concentrations than parent drug. Acyl glucuronides have shown to be potentially reactive conjugates, which may affect vitro metabolite pattern. Methods: Extraction procedures liquid chromatography-tandem mass spectrometry assay were developed validated investigate stability of THCCOOglu...